A5100419449- CAR-T cell therapy research
- Traditional Chinese Medicine Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Analysis
- Acupuncture Treatment Research Studies
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Healthcare and Venom Research
- Plant-based Medicinal Research
- Bioinformatics and Genomic Networks
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Genetic factors in colorectal cancer
- Genomics, phytochemicals, and oxidative stress
- Viral Infectious Diseases and Gene Expression in Insects
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
MacroGenics (United States)
2021-2025
Agilent Technologies (United States)
2022-2025
Shandong University of Traditional Chinese Medicine
2020-2024
Yunnan University
2024
Yunnan University of Traditional Chinese Medicine
2024
Harbin Medical University
2009-2024
Second Affiliated Hospital of Harbin Medical University
2009-2024
Southern Medical University
2024
Nanfang Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Background Availability of checkpoint inhibitors has created a paradigm shift in the management patients with solid tumors. Despite this, most do not respond to immunotherapy, and there is considerable interest developing combination therapies improve response rates outcomes. B7-H3 (CD276) member B7 family cell surface molecules provides an alternative immune molecule therapeutically target alone or programmed death-1 (PD-1)–targeted therapies. Enoblituzumab, investigational anti-B7-H3...
Abstract Senescent and suppressor T cells are reported to be increased in select patients with cancer poor prognostic indicators. Based on the association of these outcomes, we hypothesized that tumors induce senescence cells, which negatively effects antitumor immunity. In this report, show human from healthy donors incubated tumor for only 6 h at a low T-cell ratio undergo senescence-like phenotype, characterized by loss CD27 CD28 expression telomere shortening. Tumor-induced is induced...
Messenger RNA (mRNA) vaccine has fueled a great hope for cancer immunotherapy. However, low immunogenicity, caused by inefficient mRNA expression and weak immune stimulation, hampers the efficacy of vaccines. Here, we present an compartmentalization–based vaccine, comprising multimodule DNA nanostructure (MMDNS)–assembled compartment efficient translation via in situ localizing concentration relevant reaction molecules. The MMDNS is constructed programmable hybridization chain (HCR)–based...
Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed mental of children and adolescents. Although psychostimulants are currently first-line drugs for ADHD, their highly addictive profile raises great abuse concerns. It known that psychostimulants' addictiveness largely attributed to interaction with dopamine transporter (DAT) binding modes in DAT can thus facilitate understanding mechanism underlining drugs' addictiveness. However, no residue able discriminate ADHD...
Abstract Pancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity cells within tumor. T target kill by specific recognition cancer-associated antigens. In this study, from primary tumor blood sixteen patients with pancreatic were characterized deep sequencing. another eight healthy volunteers also studied as controls. By analyzing complementary determining region 3 ( CDR3 ) gene sequence, we found no significant...
Dysfunction of early endothelial progenitor cells (EPCs) is responsible for impaired repair capacity after arterial injury in patients with hypertension. Here, we hypothesized that diminished signaling CXC chemokine receptor 7 (CXCR7) contributes to the reduced EPC functions, and enhanced CXCR7 expression restores capacities EPCs from hypertensive patients. was significantly when compared healthy subjects. Meanwhile, phosphorylation p38 mitogen-activated protein kinase, a downstream CXCR7,...
Abstract Integrated traditional Chinese medicine (TCM) and Western (WM) is a new medical science grounded in the knowledge bases of both TCM WM, which then forms unique modern system China. WM has long history China, made important achievements process clinical diagnosis treatment. However, methodological defects currently published practice guidelines limit its development. The organic integration deeper WM. To realize progression "integration" to "organic integration", targeted...
Fibrolamellar carcinoma (FLC) is a liver tumor with high mortality burden and few treatment options. A promising therapeutic vulnerability in FLC its driver mutation, conserved DNAJB1-PRKACA gene fusion that could be an ideal target neoantigen for immunotherapy. In this study, we aim to define endogenous CD8 T cell responses patients evaluate fusion-specific receptors (TCRs) use cellular immunotherapies. We observe cells are rare patient TCR repertoires lack large clusters of related...
Abstract Antibody-drug conjugates (ADCs) represent a pivotal advancement in biotherapy, leveraging targeted internalization to treat tumors effectively. A critical phenomenon associated with ADCs is the bystander effect, where cytotoxic drugs released from lysed cancer cells diffuse into neighboring tumor cells, enhancing therapeutic efficacy—particularly heterogeneous antigen expression. Despite its significance, methods for detecting and evaluating effect of remain under development. In...
This study examined whether borneol could enhance corneal drug permeability. Model drugs containing either synthetic or natural were co-administered to isolated intact de-epithelialized rabbit corneas and the apparent permeability coefficients measured. Draize tests in rabbits levels of hydration used measure vivo vitro toxicity, respectively. Synthetic (0.1%) increased penetration lipophilic agents, indomethacin dexamethasone, by 1.23 2.40, respectively, hydrophilic ofloxacin, ribavirin...
Insulin resistance is highly prevalent in patients with chronic hepatitis C (CHC) and to some extent accounts for fibrosis reducing viral eradication. Activated cannabinoid 1 receptor (CB1R) signaling has been implicated the development of phenotypes associated insulin steatosis. We investigated role endocannabinoid system glucose metabolism disorders induced by virus (HCV) replication.Human hepatic stellate cells (HSC; LX-2 cells) were co-cultured Huh-7.5 or harboring HCV replicon (replicon...
This study was aimed to evaluate the effects of celastrol, a natural compound with multiple bioactivities, on sclerosis and optic neuritis in rat experimental autoimmune encephalomyelitis (EAE). EAE induced Sprague Dawley rats using myelin basic protein, animals received daily intraperitoneal injections celastrol or vehicle for 13 days. The showed abnormal neurobehavior inflammatory infiltration demyelination spinal cord. Significantly upregulated mRNA expression pro-inflammatory cytokines...
Background: Bispecific antibodies represent a promising class of biologics for cancer treatment. However, their dual specificity and complex structure pose challenges in the engineering process, often resulting molecules with good functional but poor physicochemical properties. Method: To overcome limitations properties an anti-5T4 x anti-CD3 (α5T4 αCD3) DART molecule, phage-display method was developed, which succeeded simultaneously cross-reactivity to cynomolgus 5T4 ortholog, improving...
Marine unicellular coccolithophore algae produce species-specific calcite scales otherwise known as coccoliths. While the coccoliths and their elaborate architecture have attracted attention of investigators from various scientific disciplines, our knowledge underpinnings process biomineralization in this alga is still its infancy. The processes calcification coccolithogenesis are highly regulated likely to be complex, requiring coordinated expression many genes pathways. In study, we...
Cell division cycle‑associated 5 (CDCA5) plays a critical role in the progression of various human cancers by regulating cell cycle‑related proteins; however, function CDCA5 breast cancer (BC) is poorly understood. The aim present study was to investigate expression level BC and its effect on progression. found be highly expressed patients with BC, as well lines. It also that high significantly associated shorter survival rate. In addition, increased stem cells derived from...