A5101698479- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Plant Stress Responses and Tolerance
- Kruppel-like factors research
- Plant responses to elevated CO2
- Inflammatory mediators and NSAID effects
- Photosynthetic Processes and Mechanisms
- Carbon and Quantum Dots Applications
- Neurological Complications and Syndromes
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Single-cell and spatial transcriptomics
- Macrophage Migration Inhibitory Factor
- Oral and Maxillofacial Pathology
- Metabolism, Diabetes, and Cancer
- Cardiac Fibrosis and Remodeling
- Heat shock proteins research
- Signaling Pathways in Disease
- Cytokine Signaling Pathways and Interactions
Tianjin University
2023
Tianjin Medical University
2023
Wuhan University of Science and Technology
2020-2023
Beijing Forestry University
2023
Sun Yat-sen University
2010
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like,...
miR-5100 participates in the proliferation of lung cancer and pancreatic cells, differentiation osteoblasts. However, regulation gastric cells remains unclear. The blood patients was collected to detect expression level miR-5100, apoptosis autophagy levels were detected using western blot, flow cytometry, confocal. At same time, vitro tumor formation experiments nude mice used verify results experiments. is related prognosis cancer, can enhance inhibit occurrence by targeting CAAP1. MKL1...
Near-infrared-II (NIR-II) imaging has shown great potential in medical diagnosis and surgical navigation, but developing safe, photostable, high-brightness molecular probes remains a challenge. Due to their ultrasmall size resulting highly efficient renal clearance, gold nanoclusters have clinical potential. In this work, we systematically explored the effect of different ligands on luminescence bioactivity nanoclusters. Our results show that protected by thioglycolic acid (TGA)...
Liver cancer is a malignant phenotype for which there currently remains lack of reliable biomarkers and therapeutic targets disease management. Tryptophan 2,3‑dioxygenase (TDO2), heme‑containing polyoxygenase enzyme, primarily expressed in cells the liver nervous systems. In present study, through combination bioinformatics analysis clinical patient samples, it was shown that TDO2 expression tissue samples significantly higher than normal tissues, patients with high had poor prognosis....
Cell division cycle‑associated 5 (CDCA5) plays a critical role in the progression of various human cancers by regulating cell cycle‑related proteins; however, function CDCA5 breast cancer (BC) is poorly understood. The aim present study was to investigate expression level BC and its effect on progression. found be highly expressed patients with BC, as well lines. It also that high significantly associated shorter survival rate. In addition, increased stem cells derived from...
Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for progression breast cancer and also pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in cancer. The role MKL-1s DNMT1 migration still unclear. MKL-1 (myocardin related factor A) can bind conserved cis-regulatory element CC (A/T) 6GG (called CarG box) promoter regulate miR-142-5p. expressions miR-142-5p are positively correlated. In addition, it has been...
Tooth agenesis is one of the most common developmental disorders in humans. The PAX9 gene, which plays an important role odontogenesis, associated with familial and sporadic tooth agenesis. A case–control study was performed 102 subjects (cases) 116 healthy controls. We genotyped four gene polymorphisms using a polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) assay. allele genotype frequencies were not significantly different between controls Similar results...
Cancer development and progression can be regulated by the levels of endogenous factors. Gastric cancer is an aggressive disease state with poor patient prognosis, needing new diagnostics therapeutic strategies. We investigated close association between follistatin-like 3 (FSTL3) different cancers, focused on its role in gastric cell function. Using bioinformatics, we found that FSTL3 expression elevated a large majority 33 cancers analyzed publicly available databases. Elevated associated...
Abstract Aldolase A (ALDOA), an important metabolic enzyme in the glycolytic pathway, plays role regulating tumour metabolism. In this study, we investigated expression pattern of ALDOA hepatocellular carcinoma (HCC) and its biological progression. Bioinformatics analysis, western blot (WB) RT-qPCR were performed to detect relative HCC tissues cell lines. loss-of-function approach was used investigate function ALDOA. The on glycolysis assessed by WB, glucose lactate assay kits a nude mouse...
Selecting alfalfa germplasm with high stress resistance forms the foundation for breeding new varieties of (Medicago sativa L.). This study utilized two varieties, WL298HQ and Gongnong No. 1, subjected them to individual combined cold drought stress. By measuring malondialdehyde (MDA) content among seven physiological biochemical indices through transcriptome sequencing roots leaves, we compared between under various treatments. aimed identify primary regulatory genes pathways, revealing...
Chaperonin containing TCP1 subunit 5)CCT5( is a member of the companion protein complex (CCT), also known as loop (TRiC). The expression CCT5 abnormal in many cancers, but biological role hepatocellular carcinoma (LIHC) remains to be determined. We analyzed using multiple gene databases. genes co-expressed with were identified linkedonomics. correlation between and tumor immune infiltrates was studied by estimation resource (TIMER). found up-regulated tissues LIHC queues. High associated...
Abstract Background In order to explore the molecular mechanism of cardiomyocyte-dependent myocardial gene expression and cardiomyocyte differentiation in cardiac hypertrophy, provide new insights for hypertrophy. Methods Cardiac myocytes were isolated from day 1-3 Sprague-Dawley rat pups. Real time quantitative PCR, western blot immunocytochemistry Assay used detect localization related genes. CO-IP was direct protein interactions between Myocardin STAT3. Luciferase reporter assay chromatin...
Abstract Background Aldolase A, an important metabolic enzyme in the glycolytic pathway, plays role regulating tumour metabolism. In this study, we investigated expression pattern of ALDOA hepatocellular carcinoma and its biological progression. Methods Bioinformatics analysis, Western Blot RT-qPCR were performed to detect relative tissues cell lines. A loss-of-function approach was used investigate function ALDOA. The on glycolysis apoptosis assessed by Blot, glucose lactate assay kits,...
Human epidermal growth factor receptor (HER) family belongs to the transmembrane protein of tyrosine kinase I subfamily and has been determined be closely related clinicopathological characteristics various tumors poor prognosis tumor patients. However, different expression patterns four HER genes their correlation with cancer immune infiltrate have not analyzed. In this article, we analyzed level in breast patients through Oncomine Interactive Analysis Gene Expression Profiles (GEPIA). We...