A5101401719- Nuclear Receptors and Signaling
- Cervical Cancer and HPV Research
- Infectious Diseases and Tuberculosis
- Viral-associated cancers and disorders
- Tuberculosis Research and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Connective tissue disorders research
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Autoimmune Neurological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Neurological disorders and treatments
- RNA Interference and Gene Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Circular RNAs in diseases
- Gut microbiota and health
- Prostate Cancer Diagnosis and Treatment
National Health and Family Planning Commission
2023-2025
Sichuan Academy of Traditional Chinese Medicine
2025
Wenzhou Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2012-2024
Wenzhou Central Hospital
2024
Sun Yat-sen University
2012-2024
Xi'an Jiaotong University
2023-2024
Hengyang Academy of Agricultural Sciences
2023
Nanchang Hangkong University
2023
Shenyang Agricultural University
2023
Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. expresses oncoproteins E6 and E7, both of which play key roles in maintaining viral promoting carcinogenesis. While siRNA-mediated targeting E7 transcripts temporarily induces apoptosis HPV-positive cells, it does not eliminate DNA within host genome, can harbor escape mutants. Here, we demonstrated that specifically with transcription activator-like effector nucleases (TALENs) apoptosis, inhibits...
Cervical cancer is mainly caused by infections of high-risk human papillomavirus (HR-HPV). Persistent expression HR-HPV oncogenes E6 and E7 implicated in malignant transformation. The aim was to provide proof-of-concept data support use zinc finger nucleases (ZFN) targeting HPV treat HPV-related cervical cancer.We designed constructed ZFNs that could specifically recognize cleave HPV16/18 DNA. We tested the cleavage efficiency selected ZFN16-E7-S2 ZFN18-E7-S2 using single-strand annealing...
Abstract To investigate the clinicopathologic features, Epstein–Barr virus (EBV) latency pattern and genome polymorphism of EBV‐associated gastric carcinoma (EBVaGC) in Guangzhou, an endemic area nasopharyngeal (NPC), situ hybridization assay EBV‐encoded small RNA‐1 (EBER‐1) was used to identify presence EBV 676 consecutive cases. proteins EBNA1, EBNA2, LMP1, ZEBRA were detected by immunohistochemistry. also analyzed PCR DNA sequencing. Of cases, 45 EBV‐positive cases (6.7%) identified,...
Coronavirus disease 2019 (COVID-19) has significantly affected gastrointestinal (GI) endoscopy, with jurisdictions reporting up to a 95% reduction in procedure volumes compared before the pandemic.1Rutter MD et al. Gut [published online July 20, 2020]. https://doi.org/10.1136/gutjnl-2020-322179.Google Scholar In Ontario, Canada, large volume of colonoscopies not performed during first wave pandemic (the backlog) must now be managed (Supplementary Table 1). Ontario Health (Cancer Care...
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) dysfunctional in promoting repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective vivo models. In this study we investigated whether promotes repair and restores impaired function HDL (Cl/NO2-HDL) re-endothelialization. We demonstrate that Cl/NO2-HDL act on...
From initial human papillomavirus (HPV) infection and precursor stages, the development of cervical cancer takes decades. High-sensitivity HPV DNA testing is currently recommended as primary screening method for cancer, whereas better triage methodologies are encouraged to provide accurate risk management HPV-positive women. Given that virus-driven genomic variation accumulates during carcinogenesis, we designed a 39 Mb custom capture panel targeting 17 types 522 mutant genes related cancer....
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha fusion gene (F/P) arising in the pluripotent hematopoietic stem cell (HSC),causes 14% to 60% of patients with hypereosinophilia syndrome (HES). These patients, classified as having F/P (+) chronic eosinophilic leukemia (CEL), present clonal eosinophilia and display a more aggressive disease phenotype than (-) HES patients. mechanisms underlying predominant eosinophil lineage targeting cytotoxicity eosinophils this remain...
Background and purpose: The mechanism underlying the pathology of neuromyelitis optica spectrum disorders (NMOSD) remains unclear even though antibodies to water channel protein aquaporin-4 (AQP4) on astrocytes play important roles. Our previous study showed that dysbiosis occurred in faecal microbiota NMOSD patients. In this study, we further investigated whether intestinal barrier mucosal flora balance are also interrupted Methods: Sigmoid biopsies were collected by endoscopy from six...
Abstract The endothelial dysfunction induced by oxidized low‐density lipoprotein (ox‐LDL) plays an important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and inflammation. autophagy process atherosclerosis has drawn increasing attention. human umbilical vein cells (HUVECs), whose Ras‐related C3 botulinum toxin substrate 1 (Rac1) Rac3 was knockdown, were used detect whether possible molecular mechanisms Rac1 for anti‐inflammatory effected downregulation...
ObjectiveCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.MethodsA large sample size multi-center randomized controlled trial was implemented features and identify COVID-19 disease-related sequences.ResultsIt found...
Studies have found overexpressed integrin-linked kinase (ILK) and disturbed matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) ratio in diabetic nephropathy epithelial-mesenchymal transition (EMT). However, the underlying mechanisms EMT inhibiting effect rhein need further understanding. The aim this study was to investigate possible regulating effects ILK towards MMP-9/TIMP-1 rhein. characteristic epithelial marker mesenchymal were examined by...
Background c-Myc , EZH2 and p27 were defined to modulate the behavior of prostate cancer with pro-tumoral or anti-tumoral effects had ability in predicting progression, but research their co-expression value prognosis is rarely. This study aimed investigate prognostic combining tri-marker together patients intermediate-risk after surgery. Methods Expression levels 129 assessed using immunohistochemistry a semi-quantitative manner. The expression profiles these three markers analyzed...
The incidence of childhood onset myasthenia gravis (CMG) in China is higher than that other countries; however, the reasons for this are unclear.We investigated clinical and immunological profiles CMG, assessed potential precipitating factors. For mouse studies, possible implication vaccination pathogenesis was explored.In our retrospective study, 51.22% 4,219 cases (MG) were type. cohort study uncovered pathophysiology CMG mediated by immune deviation, rather through gene mutations or virus...