A5100330741- Nutritional Studies and Diet
- Laser-Matter Interactions and Applications
- Spectroscopy and Quantum Chemical Studies
- Advanced Fiber Laser Technologies
- Obesity, Physical Activity, Diet
- Congenital Anomalies and Fetal Surgery
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Parasitic infections in humans and animals
- Traditional Chinese Medicine Analysis
- AI in cancer detection
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Parasitic Infections and Diagnostics
- Antibiotic Resistance in Bacteria
- Nanoplatforms for cancer theranostics
- Receptor Mechanisms and Signaling
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
- Terahertz technology and applications
- Phytochemistry and Biological Activities
- Nerve injury and regeneration
- DNA and Nucleic Acid Chemistry
- Light effects on plants
- Migraine and Headache Studies
National Health and Family Planning Commission
2022-2025
Hangzhou Medical College
2024-2025
Zhejiang Provincial People's Hospital
2024-2025
Chinese Center For Disease Control and Prevention
2021-2024
University of California, San Francisco
2024
Tongji Hospital
2015-2024
Zoucheng People's Hospital
2024
Huazhong University of Science and Technology
2015-2024
Dongguan University of Technology
2024
Second Affiliated Hospital of Zhengzhou University
2022-2024
Abstract Cells sense physical forces and convert them into electrical or chemical signals, a process known as mechanotransduction. Whereas extensive studies focus on mechanotransduction at the plasma membrane, little is about whether how intracellular organelles mechanical force physiological functions of organellar mechanosensing. Here we identify Drosophila TMEM63 ( Dm TMEM63) ion channel an intrinsic mechanosensor lysosome, major degradative organelle. Endogenous proteins localize to...
Grain weight and quality are always determined by grain filling. Plant microRNAs have drawn attention as key targets for regulation of size yield. However, the mechanisms that underlie remain largely unclear because complex networks control this trait. Our earlier studies demonstrated suppressed expression miR167 (STTM/MIM167) substantially increased weight. In a field test, yield up to 12.90%-21.94% significantly enhanced filling rate. Here, biochemical genetic analyses revealed regulatory...
We propose an intuitive method, called time-dependent population imaging (TDPI), to map the dynamical processes of high harmonic generation (HHG) in solids by solving Schr\"{o}dinger equation (TDSE). It is shown that real-time characteristics HHG solids, such as instantaneous photon energies emitted harmonics, can be read directly from energy-resolved oscillations electrons TDPIs. Meanwhile, short and long trajectories solid are illustrated clearly TDPI. By using TDPI, we also investigate...
We propose and theoretically demonstrate a method to generate attosecond XUV pulses with tunable ellipticity from aligned molecules irradiated by bichromatic counterrotating circularly polarized (BCCP) driving laser field. By rotating the BCCP field, attoseond pulse varies being left elliptically right polarized. The rotation of field can be easily achieved adjusting relative phases between two components. This scheme will benefit broad range applications, including exploration...
Cystic echinococcosis is a worldwide chronic zoonotic disease that threatens human health and animal husbandry. Exosome-like vesicles (ELVs) have emerged recently as mediators in the parasite-parasite inter-communication parasite-host interactions. ELVs from parasites can transfer non-coding RNAs (ncRNAs) into host cells to regulate their gene expression; however, ncRNAs profiles of E. granulosus remain unknown. Here, we isolated protoscolece (PSC)-ELVs hydatid fluid (HF)-ELVs culture medium...
<abstract abstract-type="Summary"> <sec> <b>What is already known about this topic?</b> The prevalence of insufficient physical activity (PA) among Chinese adults has shown an upward trend, reaching 22.3% in 2018. Leisure time PA (LTPA) constitutes a minimal proportion total patterns. </sec><sec> added by report?</b> adherence rate to Physical guidelines (PAGs) was 85.7%. While occupational remained the predominant form activity, its decreased. LTPA emerged from historically lowest position...
Ceftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. However, KPC variants have become main mechanism mediating CZA resistance in KPC-producing gram-negative bacteria after increasing application CZA. Our previous study revealed that CZA-resistant KPC-33 had emerged P. aeruginosa (CRPA) resulted death due hypervirulence extensive drug resistance; however, evolutionary path...
This study investigated fosA3-positive strains selected from carbapenem-resistant Escherichia coli (CREC) and further characterized them through genomic phenotypic analyses. CREC were subjected to agar dilution. Whole-genome sequencing (WGS) was used identify molecular mechanisms of fosfomycin resistance investigate plasmid structure characteristics comparative analysis. Conjugative transfer experiments evaluate ability, followed by stability assessment. Growth rate analysis evaluated the...
Body mass index (BMI) and waist circumference (WC) have been suggested to be involved in the etiology of hypertension. The present study aimed determine multiple trajectories BMI WC, then examined their associations with risks hypertension high blood pressure Chinese adults. used China Health Nutrition Survey data from 1991 2018. sample included 9651 adults aged 18 years or older. We group-based multi-trajectory modeling identify trajectories. estimated relationships between a Cox...
Studies on macronutrient intake and obesity have been inconclusive. This study examined the associations between multi-trajectories of macronutrients risk in China. We used data from 7914 adults who participated China Health Nutrition Survey at least three times 1991 to 2018. collected detailed dietary by conducting 24 h recalls weighing foods condiments household inventories. identified using group-based multi-trajectory models their with multiple Cox regression models. found four rural...
Circular RNAs (circRNAs) is a novel class of non-coding that regulate gene expression during cancer progression. Circ_0092314 newly discovered circRNA was upregulated in pancreatic (PAAD) tissues. However, the detailed functions and underlying mechanisms circ_0092314 PAAD cells remain unclear.We first determined normal tissues further investigated functional roles regulating epithelial-mesenchymal transition (EMT) cells. We also assessed regulatory action on microRNA-671 (miR-671) its target...
ABSTRACT Klebsiella pneumoniae carbapenemase (KPC) variants can contribute to resistance ceftazidime–avibactam (CZA) in (KP). However, two-copy KPC variant-mediated CZA has rarely been reported date. Here, we aimed clarify the evolutionary trajectory of driven by mutations double-copy bla KPC-2 KPC-189 carried tandem core structure (IS Kpn6-bla -IS Kpn27-tnpR 26 ) during treatment ST11 carbapenem-resistant K. (CRKP). The CZA-resistant KP strain , a variant with alanine–threonine and...
The wavelength scaling of the cutoff energy in solid high harmonic generation (HHG) is investigated theoretically by separating contributions into intraband and interband components. We find that, energies HHG exhibit essentially different dependences. Specifically, independent, whereas depends linearly on laser wavelength. Our results can uniformly interpret two current scalings reported previous researches. fundamentally for be used to distinguish mechanisms.
Electronic-current dynamics play an important role in photoinduced processes and magnetooptics. We theoretically demonstrate ultrafast oscillating-magnetic-field generation based on the electronic from current carrying states irradiated by a nonhelical, linearly polarized laser field. In this driving field, currents oscillate periodically, which is attributed to laser-induced energy shift of orbitals. These can induce strong spatial-localized oscillating magnetic field...