A5000113351- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Antibiotic Resistance in Bacteria
- Pediatric Hepatobiliary Diseases and Treatments
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and related cancers
- Plant Pathogenic Bacteria Studies
- Gastrointestinal disorders and treatments
- Herpesvirus Infections and Treatments
- Biochemical and Molecular Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Toxoplasma gondii Research Studies
- Organ Donation and Transplantation
- Infections and bacterial resistance
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
Shanghai Sixth People's Hospital
2021-2025
Shanghai Jiao Tong University
2020-2024
Zero to Three
2022
Southern Medical University
2020
Nextomics Biosciences (China)
2019
Abstract A complete and accurate genome sequence provides a fundamental tool for functional genomics DNA-informed breeding. Here, we assemble high-quality (contig N50 of 6.99 Mb) the apple anther-derived homozygous line HFTH1, including 22 telomere sequences, using combination PacBio single-molecule real-time (SMRT) sequencing, chromosome conformation capture (Hi-C) optical mapping. In comparison to Golden Delicious reference genome, identify 18,047 deletions, 12,101 insertions 14 large...
Abstract Background Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is type lipid that plays crucial role in inhibiting ferroptosis. Ficolin 3 (FCN3) component complement system, serving recognition molecule against pathogens lectin pathway. Recent studies have reported FCN3 demonstrates inhibitory effects on progression certain tumors. However, whether can modulate metabolism and remains largely...
This study investigated fosA3-positive strains selected from carbapenem-resistant Escherichia coli (CREC) and further characterized them through genomic phenotypic analyses. CREC were subjected to agar dilution. Whole-genome sequencing (WGS) was used identify molecular mechanisms of fosfomycin resistance investigate plasmid structure characteristics comparative analysis. Conjugative transfer experiments evaluate ability, followed by stability assessment. Growth rate analysis evaluated the...
Abstract Background Precise classification of the hepatic artery is helpful for preoperative surgical planning in hepatobiliary–pancreatic surgery. However, anatomy arteries variable. This study investigated anatomical variation using three-dimensional visualization and evaluation (3DVE) to develop a nomenclature system. Methods The origin course were tracked analysed by CT images acquired between 2013 2017. new system, named CRL, was developed based on origins common, right left arteries....
Complex immune contexture leads to resistance immunotherapy in hepatocellular carcinoma (HCC), and the need for new potential biomarkers of HCC is urgent. Histone chaperones are vital determinants gene expression genome stability that regulate tumor development. This study aimed investigate effect histone on immunity HCC. Bioinformatics analyses were initially performed using The Cancer Genome Atlas (TCGA) database, validated Gene Expression Omnibus (GEO) database International Consortium...
Abstract Gene expression profiling has been broadly performed in the field of cancer research. This study aims to explore key gene regulatory network and focuses on functions microRNA (miR)‐216a pancreatic (PC). PC datasets GSE15471, GSE16515, GSE32676 were used screen differentially expressed genes (DEGs) PC. A miRNA microarray analysis oncology suggested miR‐216a as an important The Kyoto Encyclopedia Genes Genomes (KEGG) that DEGs are largely enriched phosphatidyl inositol...
Primary gallbladder neuroendocrine carcinomas (GB-NEC) are malignant neoplasms that remained to be studied. In this study we aimed summarize their clinicopathological characteristics, effective treatment and prognostic factors for patients with GB-NEC.Patients GB-NEC admitted Shanghai Jiao Tong University Affiliated Sixth People's Hospital Renji Hospital, School of Medicine, from October 2012 August 2020 were enrolled. Clinicopathological characteristics our those reported in previous...
To characterize a carbapenem-resistant Pseudomonas aeruginosa (CRPA) with an IncP-2 plasmid containing novel transposon, Tn6485h, which carries both blaIMP-45 and blaAFM-1.
The clinical diagnosis and treatment of dilation the cholangiopancreatic duct in patients with ambiguous ampullary disease, termed unexplained (UDCD), is commonly difficult. This study aimed to evaluate applicability transduodenal ampullectomy (TDA) for UDCD.
Abstract Background We aimed to verify the role of hENT1 as a prognostic predictor for patients with resectable pancreatic ductal adenocarcinoma (PDAC) who underwent radical resection followed by intra-arterial infusion gemcitabine-based regimen. Methods collected surgical samples from 102 PDAC received The expression help immunohistochemistry was conducted using formalin-fixed and paraffin embedded tissues. Kaplan–Meier analyses Cox regression were used evaluate mortality hazard associated...
Abstract Background The dilation of cholangiopancreatic duct with ambiguous ampullary diseases, named unexplained (UDCD), is a common difficulty in clinical diagnosis and treatment. This study aims to evaluate the applicability transduodenal ampullectomy (TDA) treatment UDCD. Methods We first proposed surgical exploration procedure based on TDA applied it representative UDCD patient. Then we retrospectively analyzed pathological prognosis 14 patients at our hospital 181 reported by existing...
Abstract Purpose: This study intends to explore the role of preoperative main pancreatic duct stent placement in reducing intra-operative damaging rate and incidence postoperative leakage. Methods: A retrospective cohort analysis was performed for all patients with head benign tumors who were treated local excision. The divided into two groups (Standard VS Stent) depending on whether received prior surgery or not. Results: total 33 finally included analytical pool. Compared Standard group,...