A5042235039- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Surgical Treatments
- Advanced biosensing and bioanalysis techniques
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Gut microbiota and health
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Diagnosis and treatment of tuberculosis
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Liver physiology and pathology
Hebei Medical University
2023-2025
Shanghai Jiao Tong University
2015-2024
First Hospital of Jiaxing
2024
Renji Hospital
2019-2024
University of Connecticut
2022-2024
West China Medical Center of Sichuan University
2024
First People’s Hospital of Zunyi
2024
Zigong First People's Hospital
2024
Academy of Military Medical Sciences
2024
Institute of Microbiology
2024
Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution chemokines tumor microenvironment to metastasis not fully understood.Herein, we examinined several patients using chemokine ELISA array. Immunohistochemistry was used detect expression CXCL5 tissues. Human HCT116 and SW480 cell lines stably transfected with CXCL5, shCXCL5 shCXCR2 lentivirus plasmids were our vitro study. Immunoblot, immunofluorescence transwell assay examine molecular biology...
The mechanisms underlying the role of CXCL5 in tumor angiogenesis have not been fully defined. Here, we examined effect on colorectal cancer (CRC). Immunohistochemistry was used to monitor expression and CD31 CRC patients' tissues. HUVEC cell lines stably transfected with shCXCR2 shFOXD1 lentivirus plasmids were an vitro study. Based some molecular biological experiments vivo, found that upregulated tissues its level positively correlated CD31. Next, recombinant human (rhCXCL5) stimulate...
Abstract The mechanisms underlying the role of chemokines in tumor angiogenesis is still not fully understood. In this study, we detected influence CCL19 on colorectal cancer (CRC) angiogenesis. expression and CD31 CRC tissues were by immunohistochemistry. Human cell lines SW1116 SW620 stably transfected with lentivirus shRNA, HUVEC CCR7 shRNA used our study. Our study showed that was significantly low-expressed positively related to highly microvessel density. vitro, observed high-expressed...
Abstract Conventional meta-atom designs rely heavily on researchers’ prior knowledge and trial-and-error searches using full-wave simulations, resulting in time-consuming inefficient processes. Inverse design methods based optimization algorithms, such as evolutionary topological optimizations, have been introduced to metamaterials. However, none of these algorithms are general enough fulfill multi-objective tasks. Recently, deep learning represented by generative adversarial networks (GANs)...
Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in naive DME, lost rDME. VEGF overexpression the mouse retina caused delayed cytokine upregulation, monocyte/macrophage infiltration (CD11b+ Ly6C+ CCR2+ cells), macrophage/microglia activation CD80+ blood-retinal barrier disruption due claudin-5...
Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy. The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) 2020. However, its inadequate anti-cancer activity solid tumors limits clinical application. In this study, we utilized multiple cell lines, which are less sensitive to GSK126, combining animal model data investigate underlying mechanism.IncuCyte S3 used explore difference responsiveness hematological...
The forecast accuracy of the European Association for Study Liver-Chronic Liver Failure (EASL-CLIF) and Asian Pacific (APASL) acute-on-chronic liver failure (ACLF) criteria in assessing long-term outcomes after transplantation (LT) is still unclear, especially when staging two standards inconsistent.A retrospective cohort (NCT05036031) including 565 patients from January 2015 to June 2021 was conducted. 28 90 days, 1- 3-years overall survival (OS) LT were compared between different...
Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role PLK3 colorectal cancer (CRC) progression and glucose metabolism remains to be known.The expression CRC tissues was determined by immunohistochemistry. Cells proliferation examined EdU, CCK-8 vivo analyses. Glucose assessed detecting lactate production, uptake, mitochondrial respiration, extracellular acidification rate, oxygen consumption rate ATP production. Chromatin...
Cadherin-12 (CDH12) is a subtype of N-cadherin family. In this study, we investigated the expression CDH12 and role in prognosis colorectal cancer (CRC) patients. addition, observed influence on proliferation progression CRC cell lines. By using immunohistochemical staining, analyzed samples adjacent non-tumor tissues collected from 78 patients who underwent laparoscopic surgery Shanghai Minimally Invasive Center, China. Statistical analyses were used to analyze relationship between tumor...
Chemokines and chemokine receptors are causally involved in the metastasis of human malignancies. As a crucial receptor for mediating immune homeostasis, however, role CCR4 colorectal cancer (CRC) remains unknown. In this study, we found that high expression CRC tissues was correlated with shorter overall survival disease free survival. vitro vivo experiments revealed silencing attenuated invasion cells, whereas ectopic overexpression contributed to forced these cells. We further...
Abstract Chemoresistance remains the primary challenge of clinical treatment gastric cancer (GC), making biomarkers chemoresistance crucial for decision. Our previous study has reported that p21-actived kinase 6 (PAK6) is a prognostic factor selecting which patients with GC are resistant to 5-fluorouracil/oxaliplatin chemotherapy. However, mechanistic role PAK6 in chemosensitivity unknown. The present identified as an important modulator DNA damage response (DDR) and GC. Analysis specimens...
Tourette syndrome (TS) is a common chronic neuropsychiatric disorder with prevalence of approximately 1% in children and adolescents. TS characterized by sudden involuntary motor tics along vocal tics. A pathological study on postmortem patients has reported 50-60% reduction striatal gamma-aminobutyric acidergic (GABAergic) interneurons, suggesting role for GABAergic system imbalances tic development. However, the effect exogenous GABA administration alleviation remains unreported. In this...
Radiotherapy remains one of the cornerstones to improve outcome colorectal cancer (CRC) patients. CRC not only help destroy cells but also remodel tumour microenvironment by enhancing tumour-specific tropism bone marrow-derived mesenchymal stromal cell (BM-MSC) from peripheral circulation. However, role local MSCs and recruited BM-MSC under radiation were well defined. Indeed, functions without irradiation intervention remained controversial in progression: was previously shown modulate...
Abstract Background Precise classification of the hepatic artery is helpful for preoperative surgical planning in hepatobiliary–pancreatic surgery. However, anatomy arteries variable. This study investigated anatomical variation using three-dimensional visualization and evaluation (3DVE) to develop a nomenclature system. Methods The origin course were tracked analysed by CT images acquired between 2013 2017. new system, named CRL, was developed based on origins common, right left arteries....
Abstract Background Cadherin 12 (CDH12), which encodes a type II classical cadherin from the superfamily, may mediate calcium-dependent cell adhesion. It has been demonstrated that CDH12 could play an important role in invasion and metastasis of salivary adenoid cystic carcinoma. We decided to investigate relationship between expression level clinicopathologic variables colorectal carcinoma (CRC) patients explore functions tumorigenesis CRC. Methods The levels tissues were detected by...