A5054739096- Ovarian function and disorders
- Metal-Organic Frameworks: Synthesis and Applications
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Adsorption and biosorption for pollutant removal
- Sleep and Wakefulness Research
- Ginseng Biological Effects and Applications
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Covalent Organic Framework Applications
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Lipid metabolism and disorders
- Preterm Birth and Chorioamnionitis
- Photoreceptor and optogenetics research
- Railway Systems and Energy Efficiency
- Advanced biosensing and bioanalysis techniques
- Membrane-based Ion Separation Techniques
- Bacterial Infections and Vaccines
- Regulation of Appetite and Obesity
- Cannabis and Cannabinoid Research
- Kruppel-like factors research
- Adenosine and Purinergic Signaling
- Pharmacological Receptor Mechanisms and Effects
- Transportation Planning and Optimization
Shandong First Medical University
2022-2024
Xiamen University
2023-2024
Zhejiang University
2019-2024
Zhejiang Lab
2024
Nanchang University
2024
Nanjing University of Chinese Medicine
2017-2022
Second Affiliated Hospital of Zhejiang University
2020-2022
Shanghai Maritime University
2022
CM Hospital
2020
Abstract The amygdala, which is involved in various behaviors and emotions, reported to connect with the whole brain. However, long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus generate whole-brain map main mouse amygdala. We identified 37 individual regions that projected neurons expressing vesicular glutamate transporter 2, 78 parvalbumin-expressing neurons, 104 protein kinase C-δ, 89 somatostatin-expressing neurons....
Defensive behaviors induced by innate fear or Pavlovian conditioning are crucial for animals to avoid threats and ensure survival. The zona incerta (ZI) has been demonstrated play important roles in learning memory, as well modulating auditory-induced defensive behavior. However, whether the neuronal subtypes ZI specific circuits can mediate response is largely unknown. Here, we found that somatostatin (SST)-positive neurons rostral of mice were activated a visual stimulus. Optogenetic...
Abstract To investigate the effect of puerarin on insulin resistance and inflammation in rats with gestational diabetes mellitus (GDM). Gestational diabetic model were established by intraperitoneal injection streptozotocin (25 mg/kg) combined high-fat feeding randomly assigned to three groups: control group, GDM puerarin-treated group. Puerarin was intragastrically administered daily until offspring born. The both group same volume normal saline. Serum total cholesterol, triglycerides,...
Bacterial extracellular vesicles (bEVs) secreted by Gram-negative bacteria are referred to as outer membrane (OMVs) because they originate in the membrane. OMVs membrane-coated 20–250 nm size. They contain lipopolysaccharide (LPS), peptidoglycan, proteins, lipids, nucleic acids, and other substances derived from their parent participate transmission of information host cells. have broad prospects terms potential application fields adjuvants, vaccines, drug delivery vehicles. Currently, there...
Polycystic ovary syndrome (PCOS) is the most common female endocrine disease. Cangfu Daotan Decoction (CDD) can effectively relieve clinical symptoms of PCOS patients.To explore active ingredients and related pathways CDD for treating PCOS, a network pharmacology-based analysis was carried out. The their potential targets were obtained from TCM system pharmacology platform. PCOS-related genes OMIM GeneCards imported to establish protein-protein interaction networks in STRING. Finally, GO...
Abstract Background: Polycystic ovary syndrome (PCOS) is a female endocrine disease with high incidence. At present, drug treatment still the main therapeutic strategy for PCOS. Traditional Chinese medicine has long history in of menstrual disorders. Shouwu Jiangqi Decoction (SWJQD) traditional herbal prescribed clinical setting as remedy Acupuncture also plays an important role regulating cycle and treating This study aims to examine efficacy safety combination SWJQD acupuncture Methods:...
Elimination of toxic Cr(VI) in industrial effluent is essential; numerous adsorbents have been developed for adsorption, but a sustainable adsorbent with chemical-less and environmentally friendly regeneration methods that could greatly reduce chemical eluent usages, recycling costs, secondary pollution still lacking. Here, we report copolymer network diallyldimethylammonium chloride N-isopropylacrylamide (pDDA-pNIPAm) functionalized metal–organic framework (MOF) materials as thermally...
Hepatic ischemia-reperfusion injury (HIRI) often occurs in liver surgery, such as partial hepatectomy and transplantation, which myeloid macrophage-mediated inflammation plays a critical role. Cell division cycle 42 (Cdc42) regulates cell migration, cytoskeleton rearrangement, polarity. In this study, we explore the role of Cdc42 HIRI. Mouse HIRI models were established with 1-hour ischemia followed by 12-hour reperfusion knockout (Cdc42mye) Cdc42flox mice. Myeloid-derived macrophages traced...
Complement activation and prefrontal cortical dysfunction both contribute to the pathogenesis of major depressive disorder (MDD), but their interplay in MDD is unclear. We here studied role complement C3a receptor (C3aR) medial cortex (mPFC) its influence on depressive-like behaviors induced by systematic lipopolysaccharides (LPS) administration. C3aR knockout (KO) or intra-mPFC antagonism confers resilience, whereas expression mPFC neurons makes KO mice susceptible LPS-induced behaviors....
In this study, four poly(diallyl dimethylammonium chloride) (PDDA) with different molecular weights are applied for forward osmosis concentration of high-salinity wastewater; meanwhile, the quantified effect osmotic pressure and viscosity on FO water flux is studied systematically. The 35 wt % PDDA (<100 kDa) solution could provide a 8.8 LMH DI as feed, 8.0 15,400 ppm synthetic wastewater feed. Osmotic plays major positive role in flux, while secondary negative role. Specifically, exhibited...
Some studies have reported an association between the Methylenetetrahydrofolate reductase (MTHFR) C667T genetic variant and risk of polycystic ovary syndrome (PCOS), although results remain controversial. A systematic search was conducted on PubMed, Web Science, EMBASE, Ovid, Chinese National Knowledge Databases WanFang databases with relevant keywords. Fourteen sixteen distinct populations involving 1478 PCOS cases used to conduct a meta-analysis. The T allele not significantly associated...
Developing a living prosthetic breast to inhibit potential cancer recurrence and simultaneously promote reconstruction would be promising strategy for clinical treatment of after mastectomy. Here, in the form injectable gelatin methacryloyl microspheres is prepared, where they encapsulated zeolitic imidazolate framework (ZIF) nanoparticles loaded with small molecules urolithin C (Uro-C) adipose-derived stem cells (ADSCs). Taking advantage acidic tumor microenvironment, ZIF triggered...
The dorsal hippocampus plays a pivotal role in spatial memory. However, the of subregion-specific molecular pathways cognition remains unclear. We observed that transcriptional coregulator C-terminal binding protein 2 (CtBP2) presented CA3-specific enrichment expression. RNAi interference CtBP2 CA3 (dCA3) neurons, but not ventral (vCA3), specifically impaired reference memory and reduced expression GluR2, calcium permeability determinant subunit AMPA receptors. Application an antagonist for...
Reactive oxygen species (ROS) are pivotal signaling molecules that control a variety of physiological functions. As member the ROS family, peroxynitrite (ONOO-) possesses strong oxidation and nitrification abilities. Abnormally elevated levels ONOO- can lead to cellular oxidative stress, which may cause several diseases. In this work, based on rhodamine fluorophore, we designed synthesized novel small-molecule fluorescent probe (DH-1) for ONOO-. Upon reaction with ONOO-, DH-1 exhibited...