A5000560112- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Cannabis and Cannabinoid Research
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Cognitive Abilities and Testing
- Ion channel regulation and function
- Axon Guidance and Neuronal Signaling
Sir Run Run Shaw Hospital
2018-2024
Zhejiang University
2011-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Zhejiang Lab
2021
ORCID
2019
Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may regulate excitability of fast-spiking neurons in frontal cortex and participate primary epilepsy pathogenesis. However, exact roles mechanism for NRG1/ErbB4 human symptomatic are still unclear. Using fresh tissues, we found protein levels NRG1 ErbB4 were significantly increased temporal cortex. In addition, NRG1-ErbB4 suppressed phosphorylation GluN2B at position 1472 by Src kinase, decreased level detected...
Dysfunction of the noradrenergic (NE) neurons is implicated in pathogenesis bipolar disorder (BPD). ErbB4 highly expressed NE neurons, and its genetic variation has been linked to BPD; however, how regulates neuronal function contributes BPD unclear. Here we find that conditional deletion locus coeruleus (LC) increases spontaneous firing through NMDA receptor hyperfunction, elevates catecholamines cerebrospinal fluid (CSF). Furthermore, Erbb4-deficient mice present mania-like behaviors,...
Methyl-CpG-binding protein 2 (MeCP2) encoded by the MECP2 gene is a transcriptional regulator whose mutations cause Rett syndrome (RTT). Mecp2-deficient mice show fear regulation impairment; however, cellular and molecular mechanisms underlying this abnormal behavior are largely uncharacterized. Here, we showed that Mecp2 deficiency in cholinergic interneurons of nucleus accumbens (NAc) dramatically impaired learning. We further found spontaneous activity decreased, mediated enhanced...
Complement activation and prefrontal cortical dysfunction both contribute to the pathogenesis of major depressive disorder (MDD), but their interplay in MDD is unclear. We here studied role complement C3a receptor (C3aR) medial cortex (mPFC) its influence on depressive-like behaviors induced by systematic lipopolysaccharides (LPS) administration. C3aR knockout (KO) or intra-mPFC antagonism confers resilience, whereas expression mPFC neurons makes KO mice susceptible LPS-induced behaviors....
The central cholinergic nervous system plays an important role in cognition, with acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type A (BoNT/A), potent poison secreted by Clostridium botulinum, is used widely for dystonia treatment and facial cosmesis. BoNT/A injection inhibits release the neuromuscular junction through cleavage synaptosomal-associated protein 25 kDa terminals. Furthermore, beyond site, undergoes retrograde transport transcytosis...
Botulinum toxin type A (BoNT/A) is extensively applied in spasticity and dystonia as it cleaves synaptosome-associated protein 25 (SNAP25) the presynaptic terminals, thereby inhibiting neurotransmission. An increasing number of randomized clinical trials have suggested that glabellar BoNT/A injection improves depressive symptoms patients with major disorder (MDD). However, underlying neuronal circuitry BoNT/A-regulated depression remains largely uncharacterized. Here, we modeled MDD using...
Dysfunction of the noradrenergic (NE) neurons is implicated in pathogenesis manic-depressive psychosis (MDP). ErbB4 highly expressed NE neurons, and its genetic variation has been linked to MDP; however, how regulates neuronal function contributes MDP unclear. Here we find that conditional deletion locus coeruleus (LC) increases spontaneous firing through NMDA receptor hyperfunction, elevates catecholamines cerebrospinal fluid (CSF). Furthermore, ErbB4-deficient mice present mania-like...
Botulinum neurotoxin type A (BoNT/A) is a potent metalloprotease that acts primarily by specifically cleavage of presynaptic synaptosomal-associated 25 kDa (SNAP-25), consequently blocking the release neurotransmitters such as acetylcholine (ACh) at neuromuscular junction and autonomic innervations glands smooth muscles. Long-term repeated application BoNT/A therapeutic basis for diseases dystonia, muscle spasms so on. Accumulating evidence suggested toxin can be retrograde axonal...