A5102996818- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Shoulder and Clavicle Injuries
- Diet and metabolism studies
- Trauma Management and Diagnosis
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Cancer Mechanisms and Therapy
- MRI in cancer diagnosis
- Caveolin-1 and cellular processes
- Lipid metabolism and disorders
- Neurological and metabolic disorders
- Gout, Hyperuricemia, Uric Acid
- Genetic Associations and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Vasculitis and related conditions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Xizang Minzu University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Soochow University
2017-2024
Sir Run Run Shaw Hospital
2018-2024
Zhejiang University
2018-2024
Second Affiliated Hospital of Soochow University
2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Marvell (Israel)
2024
MRS Training & Rescue
2022
Background and Purpose— Symptomatic intracranial hemorrhage (SICH) pose a major safety concern for endovascular treatment of acute ischemic stroke. This study aimed to evaluate the risk related factors SICH after in real-world practice. Methods— Patients with stroke treated stent-like retrievers recanalizing blocked artery anterior circulation were enrolled from 21 centers China. Intracranial was classified as symptomatic asymptomatic ones according Heidelberg Bleeding Classification....
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
Importance It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. Objective To assess the efficacy and adverse events of adjunctive low-dose thrombectomy secondary LVO. Design, Setting, Participants This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 proximal intracranial LVO...
<b><i>Background and Objective:</i></b> Endovascular treatment (EVT) is proven to be safe effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of ischemic stroke. This study aims explore relationship between NLR clinical outcomes LVOS patients undergoing EVT. <b><i>Methods:</i></b> Patients were selected from EVT...
<b><i>Backgrounds and Purpose:</i></b> This study was aimed at investigating the outcomes predictors for poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population. <b><i>Methods:</i></b> Between January 2014 June 2016, acute stroke patients with anterior circulation occlusion EVT were retrospectively enrolled from 21 centers China. The main modified Rankin Scale (0-2 as independence, 3-6 poor) 90 days,...
Background and purpose Whether intravenous thrombolysis prior to endovascular treatment in patients with anterior circulation large‐vessel occlusion ( LVO ) is indispensable remains unclear. The aim was retrospectively compare, a Chinese population, the effectiveness safety of direct DEVT initiated within 4.5 h after onset bridging therapy acute stroke patients. Methods A total 363 patients, 160 group 203 group, were enrolled between 2014 2016. Using propensity score matching analysis, 276...
Objective The objective of this article is to compare the effectiveness primary angioplasty and/or stenting with stent retriever thrombectomy in acute anterior large-vessel occlusion due atherosclerotic disease. Methods Patients were retrospectively reviewed from endovascular treatment for circulation ischemic stroke registry. occlusions atherosclerosis selected. We evaluated modified Rankin Scale (mRS) score at 90 days, thrombolysis cerebral infarction (mTICI) immediately post-procedure,...
Objective Asymptomatic intracranial hemorrhage (aSICH) is a common phenomenon after endovascular treatment of acute ischemic stroke, but its prognostic impacts remain unclear. This study evaluated functional outcomes thrombectomy in patients with and without aSICH. Methods Patients stroke due to large artery occlusion the anterior circulation who were treated enrolled 21 centers. According CT scans performed within 72 hours procedures, aSICH or included while symptomatic (SICH) excluded....
Background The relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although is associated cardiovascular cerebrovascular risk, the specific link normalized (SUA/SCr) recurrence impaired has not been well studied. This study aims to fill this gap by investigating association SUA/SCr 1-year AIS function. Methods utilized ratio of (SUA) creatinine (SCr) represent SUA for Abnormal Renal was defined...
Pain caused by chest tube placed after uniportal video-assisted thoracoscopic surgery (UVATS) is often neglected. Ropivacaine can be used to alleviate pain related the tube, but current lowest effective concentration of ropivacaine remains unclear. To investigate analgesic effect administering two different concentrations into pleural cavity via drainage bypass UVATS. Ninety patients were randomly divided three groups: Control group (PCIA only), Low-dose combined with intrathoracic infusion...
To determine the influence of renal impairment (RI) on clinical outcomes at 3 months and risk recurrent stroke in patients presenting with emergent large vessel occlusion (ELVO) treated endovascular treatment (EVT).Consecutive anterior circulation due to ELVO EVT 21 centers were included. Multivariate regressions used evaluate association RI mortality, functional independence (modified Rankin Scale [mRS] score 0-2), improvement (shift mRS score) months. The between was evaluated multivariate...
Objective To compare outcomes following intracranial stent retriever-based thrombectomy (SRT) with emergency extracranial internal carotid artery (EICA) stenting or angioplasty alone in patients presenting acute stroke due to tandem occlusions of the ICA. Methods Consecutive anterior occlusion who received an endovascular intervention within 6h symptom onset between January 2013 and June 2016 were included this prospective study. Demographic, radiological, procedural clinical outcome data...
Objective The endovascular treatment strategy for acute tandem occlusion stroke is challenging, and controversy exists regarding which lesion should be treated first. This study addresses the uncertainty priority choice thrombectomy in anterior circulation stroke. Methods We analysed clinical angiographic data of patients who underwent interventional therapy from endovAsCular Treatment acUte Anterior circuLation ischaemic (ACTUAL) registry. Recanalisation was assessed according to modified...
Hemorrhagic transformation can complicate ischemic strokes after recanalization treatment within a time window that requires early intervention. To determine potential therapeutic effects of matrilin-3, rat cerebral ischemia-reperfusion was produced using transient middle artery occlusion (tMCAO); intracranial hemorrhage and infarct volumes were assayed through hemoglobin determination 2,3,5-triphenyltetrazoliumchloride (TTC) staining, respectively. Oxygen-glucose deprivation (OGD) modeling...
Introduction Symptomatic intracranial hemorrhage (sICH) is a serious complication of acute ischemic stroke (AIS) after endovascular treatment (EVT). Limited data exist regarding predictors and clinical implications sICH EVT, underscoring the significance identifying risk factors to enhance prevention strategies. Therefore, main objective this study was evaluate incidence identify its EVT in patients with large infarct core-AIS pre-circulation stage. Methods Using from for Pre-circulation...
In clinical practice, stent diameter is one of the variable properties important for endovascular treatment. A consensus guideline retriever size selection has yet to be established. The aim this study was investigate effects different diameters Solitaire retrievers on outcomes.Of 628 patients enrolled from Endovascular Treatment Acute Anterior Circulation Ischemic Stroke Registry, 256 were treated with 4-mm device and 372, 6-mm device. We matched 2 sizes using propensity score analysis....
Caveolin-1 (Cav-1) plays pivotal roles in the endothelial damage following stroke. The present study aimed to investigate whether serum Cav-1 level is associated with presence of cerebral small vessel disease (cSVD) patients acute ischemic To this end, 156 were consecutively enrolled. Cranial magnetic resonance imaging was analyzed determine surrogates cSVD, including microbleeds (CMBs), silent lacunar infarcts (SLIs), and white matter hyperintensities (WMHs). After adjusting for potential...