A5087598070- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Cardiac Fibrosis and Remodeling
- Neurological Disorders and Treatments
- Iron Metabolism and Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone Metabolism and Diseases
- Diabetic Foot Ulcer Assessment and Management
- Alzheimer's disease research and treatments
- Dialysis and Renal Disease Management
- Hemoglobinopathies and Related Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Erythropoietin and Anemia Treatment
- Animal Nutrition and Physiology
Zhongnan Hospital of Wuhan University
2011-2025
Wuhan University
2014-2025
Xuzhou Medical College
2023-2024
Chengdu Fifth People's Hospital
2023-2024
Army Medical University
2024
Capital Medical University
2021-2023
Affiliated Hospital of Xuzhou Medical College
2023
Beijing Tian Tan Hospital
2023
West China Second University Hospital of Sichuan University
2022
Sichuan University
2022
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
BACKGROUND: The present study aimed to evaluate the efficacy and safety of intravenous tirofiban versus alteplase before endovascular treatment (EVT) in acute ischemic stroke patients with intracranial large vessel occlusion. METHODS: This was a post hoc analysis using data from 2 multicenter, randomized trials: DEVT trial (Direct Endovascular Treatment for Large Vessel Occlusion Stroke) May 2018 2020 RESCUE BT (Intravenous Tirofiban Before Thrombectomy Acute Ischemic October 2021. Patients...
Background Mild stroke may lead to cognitive impairment, and it remains unclear whether intravenous thrombolysis (IVT) can mitigate deficits. This study investigates IVT help alleviate function impairment in patients further explores changes the topological properties of cerebral blood flow (CBF) networks. Methods observational prospectively enrolled 94 with acute mild ischemic (44 vs. 50 non-IVT) from two hospitals. A battery neuropsychological tests arterial spin labeling were performed...
Background: Selective serotonin reuptake inhibitors improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) rat hippocampus. However, effects selective on serum BDNF levels vascular dementia are largely unknown. We performed an open-label study to investigate fluoxetine, a inhibitor, dementia. Methods: Fifty were randomly allocated receive fluoxetine (20 mg/day; n=25) or no (control group; for 12 weeks. Both groups received secondary...
The crystals of two binuclear copper-based complexes were obtained. One complex can remarkably induce apoptosis and inhibit angiogenesis to mediate tumour growth at a greater extent. Furthermore, this showed strong energy-dependent non-endocytotic uptake exhibited multiple anti-cancer functions by inhibiting the expressions p-Akt p-Erk1/2 proteins decreasing levels reactive oxygen species.
Background Phosphodiesterase III (PDE3) inhibitors are inotropic agents used to treat congestive heart failure (CHF) and less effective in patients with severe CHF. Little is known about relative changes PDE3 activity or gene expression during the evolution of cardiomyopathy. Methods Results In present study, we evaluated temporal PDE3A before after pacing-induced CHF nine mongrel dogs. Three weeks left ventricular (LV) pacing produced LV end-diastolic pressures 15±1.7 mm Hg, whereas overt...
Asymptomatic carotid artery stenosis can lead to not only stroke but also cognition impairment. Although it has been proven that stenting (CAS) reduce the risk of future strokes, effect CAS on is conflicting. In recent years, pulsed arterial spin labeling (pASL) MRI and resting-state functional (R-fMRI) have employed in cognitive impairment studies. For present study, evaluated severe asymptomatic patients undergoing CAS, mechanisms underlying change are explored by pASL R-fMRI.We...
The aim of the present study was to investigate prevalence hyperhomocysteinaemia (HHCY; total plasma homocysteine (tHcy) concentration >15 μmol/l) and its major determinants in healthy Chinese northerners. A descriptive cross-sectional conducted Shaanxi Province, China. sample included 2645 participants (1042 men 1603 women) aged >20 years. Demographic characteristics lifestyle factors were assessed via questionnaire interviews physical examination. Plasma levels folate...
Abstract Introduction High glucose levels are associated with cognitive impairment and total hippocampal volume reductions. However, the effects of blood level on subfield volumes remain unclear, especially in prediabetes stage. Methods Sixty participants were enrolled this cross‐sectional study divided into nondiabetes, prediabetes, diabetes groups according to their medical history A1c level. A full battery neuropsychological tests was used assess global cognition, executive function,...
Background: Endothelial-to-mesenchymal transition (EndMT) is an important source of myofibroblasts that directly affects cardiac function in diabetic cardiomyopathy (DCM) via unknown underlying mechanism. Sirt6 a member the Sirtuin family NAD(+)-dependent enzymes plays role glucose and fatty acid metabolism. In this study, we investigated whether participates EndMT during development T2DM possible regulatory mechanisms. Methods: Endothelium-specific knockout (Sirt6-KO EC ) mice (C57BL/6...
Background and Objective: Branch atheromatous disease (BAD) is distinctive from large-artery atherosclerosis small-vessel disease, which single subcortical infarction caused by the occlusion of perforator's orifice. This study aimed to indicate whether intravenous thrombolysis (IVT) with alteplase could prevent early neurological deterioration (END) improve functional outcome for patients BAD within 4.5 h after symptom onset. Methods: We retrospectively analyzed data collected who were...
Background and objective This study aims to examine the role of neurovascular coupling (NVC) in vascular cognitive impairment (VCI) by investigating relationship between white matter lesion (WML) burden, NVC, deficits. Additionally, we aim explore potential NVC as a tool for understanding neural mechanisms underlying VCI. Methods included thirty-eight small vessel disease (SVCI) patients, 34 post-stroke (PSCI) 43 healthy controls (HC). Comprehensive assessments, including neuroimaging...
Osteomyelitis (OM) is an inflammatory condition of bone characterized by cortical devascularization and necrosis. Dysregulation remodelling triggered OM. Bone precisely coordinated resorption formation via a reversal phase. However, the cellular molecular mechanisms underlying failure after osteomyelitis remain elusive. To elucidate mechanism healing osteomyelitis, we employed single-cell RNA sequencing (scRNA-seq) to depict atlas human in normal, infected reconstructed states....
To investigate whether hyperdense middle cerebral artery sign (HMCAS) on pretreatment no-contrast CT (NCCT) is associated with hemorrhagic transformation (HT) after endovascular thrombectomy (EVT).Patients acute (MCA) occlusion who received EVT in three comprehensive hospitals were retrospectively evaluated. They divided into four groups based the presence or absence of HMCAS and corresponding CTA findings, among whom differences compared. Univariate multivariate logistic regression analyses...
Although cognitive deficit is a common non-motor symptom of Parkinson's disease (PD), the mechanism and valid biomarkers it have not been identified. To our best knowledge, this was first study to investigate intrinsic dysconnectivity pattern whole-brain functional networks in early-stage drug-naive (ESDN) PD patients its association with using voxel-wise Degree Centrality (DC) approach.A total 53 ESDN healthy controls (HC) were recruited. Resting-state fMRI (rs-fMRI) data acquired, DC...
Young ischaemic stroke patients often suffer from cognitive impairment after stroke. However, the risk factors of are still unclear. This study examined impact vascular (VRFs) on in first-ever young patients.Subjects were divided into low (0-1 VRF, n = 27), medium (2-3 VRFs, 45) and high-risk (≥4 12) groups according to their number VRFs. The following VRFs collected: hypertension, diabetes mellitus, dyslipidaemia, atrial fibrillation, obesity, smoking, excess alcohol consumption, coronary...
Cardiac remodeling and dysfunction are responsible for the high mortality after myocardial infarction (MI). We assessed potential Shank3 to alleviate post-infarction cardiac dysfunction. The experimental MI mice model was constructed by left anterior descending coronary artery ligation. knockout aggravated MI, while overexpression alleviated it. histological examination showed that infarct size significantly increased in acute phase of group, group even more severe than revealed...
Hypertension increases the risk of cognitive impairment independent detectable stroke or cerebral lesions. However, principal pathophysiological basis this increase has not been fully elucidated. The present study investigates relationships among blood pressure, hippocampal subfields volume, and function in a relatively young non-stroke population. A total 59 non-dementia subjects (mean age, 57.2 ± 4.9 years) were enrolled. All subjected to complete assessment vascular factors including...