A5026802483- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- S100 Proteins and Annexins
- Advanced Photocatalysis Techniques
- Molecular Sensors and Ion Detection
- Perovskite Materials and Applications
- Electron and X-Ray Spectroscopy Techniques
- Advancements in Photolithography Techniques
- Organic Electronics and Photovoltaics
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastric Cancer Management and Outcomes
- Geoscience and Mining Technology
- Covalent Organic Framework Applications
- Cardiac Ischemia and Reperfusion
- Acute Lymphoblastic Leukemia research
- Educational Reforms and Innovations
- Advanced Electron Microscopy Techniques and Applications
- Geomechanics and Mining Engineering
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
Chongqing University
2024-2025
Jilin University
2016-2025
Union Hospital
2008-2025
Fujian Medical University
2023-2025
Jiangmen Central Hospital
2025
Duke University Hospital
2002-2024
Duke Medical Center
2005-2024
University of Pennsylvania
2024
Nanjing Foreign Language School
2024
Yingkou Institute of Technology
2023-2024
We report a facile approach to prepare an artificial enzyme system for tandem catalysis. NiPd hollow nanoparticles and glucose oxidase (GOx) were simultaneously immobilized on the zeolitic imidazolate framework 8 (ZIF-8) via co-precipitation method. The as-prepared GOx@ZIF-8(NiPd) nanoflower not only exhibited peroxidase-like activity of but also maintained enzymatic GOx. A colorimetric sensor rapid detection was realized through based multi-enzyme system. Moreover, modified electrode showed...
Designing heterojunction photocatalysts imitating natural photosynthetic systems has been a promising approach for photocatalytic hydrogen generation. However, in the traditional Z-Scheme artificial systems, poor charge separation, and rapid recombination of photogenerated carriers remain huge bottleneck. To rationally design S-Scheme (i.e., Step scheme) heterojunctions by avoiding futile transport routes is therefore seen as an attractive to achieving high evolution rates. Herein, twin...
A novel one-pot strategy is proposed to fabricate 3D porous graphene (3D GN) decorated with Fe3O4 nanoparticles (Fe3O4 NPs) by using hemin as iron source. During the process, oxide was simultaneously reduced and self-assembled form hydrogel while NPs synthesized from distributed uniformly on GN. The preparation process simple, facile, economical, green. obtained freeze-dried product GH-5) exhibits outstanding peroxidase-like activity. Compared traditional 2D graphene-based nanocomposites,...
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
In our quest to leverage the capabilities of emerging single-atom catalysts (SACs) for wastewater purification, we confronted fundamental challenges related electron scarcity and instability. Through meticulous theoretical calculations, identified optimal placements nitrogen vacancies (Nv) iron (Fe) sites, uncovering a dual-site approach that significantly amplified visible-light absorption charge transfer dynamics. Informed by these computational insights, cleverly integrated Nv into...
Abstract Artificial photosynthesis using carbon nitride (g-C 3 N 4 ) holds a great promise for sustainable and cost-effective H 2 O production, but the high carrier recombination rate impedes its efficiency. To tackle this challenge, we propose an innovative method involving multispecies iodine mediators (I − /I intercalation through pre-photo-oxidation process potassium iodide (suspected deteriorated “KI”) within g-C framework. Moreover, introduce external electric field by incorporating...
The thermodynamics and kinetics of the interaction dihydrofolate reductase (DHFR) with methotrexate have been studied by using fluorescence, stopped-flow, single-molecule methods. DHFR was modified to permit covalent addition a fluorescent molecule, Alexa 488, biotin at N terminus molecule. molecule placed on protein loop that closes over when binding occurs, thus causing quenching fluorescence. used attach enzyme in an active form glass surface for studies. equilibrium dissociation constant...
Recent studies have shown that hyperglycemia is a principal cause of cellular damage in patients with diabetes mellitus. A major consequence increased oxidative stress. Glucose-6-phosphate dehydrogenase (G6PD) plays an essential role the regulation stress by primarily regulating NADPH, main intracellular reductant. In this paper we show glucose (10–25 mm) caused inhibition G6PD resulting decreased NADPH levels bovine aortic endothelial cells (BAEC). Inhibition was seen within 15 min. High...
A schematic presentation for triple-enzyme mimetic activity of NiPd hNPs.
Annexin A1 (ANXA1), a mediator of the anti-inflammatory action glucocorticoids, is important in cancer development and progression, whereas NF-kappaB regulates multiple cellular phenomena, some them associated with inflammation cancer. We showed that glucocorticoids chemopreventive modified nonsteroidal drugs, such as nitric oxide-donating aspirin (NO-ASA) phospho-aspirin, induced ANXA1 cultured human colon pancreatic cells. suppressed its transcriptional activity by preventing binding to...
Here, we report ZIF-8-reduced graphene oxide (ZIF-8–rGO)-supported bimetallic AuPt nanoparticles (AuPtNPs) as a novel peroxidase mimic for high-sensitivity detection of H2O2 in neutral solution. ZIF-8–graphene (ZIF-8–GO) is first synthesized via simple wet-chemistry process and subsequently immobilized with AuPtNPs reduction method. The resultant AuPt/ZIF-8–rGO shows enhanced peroxidase-like catalytic activity it applied the electrochemical wide concentration range, from 100 nM to 18 mM,...
In this paper, a new class of metal-free nanocarbon catalyst—nitrogen (N) and sulfur (S) codoped graphene quantum dot/graphene (NS-GQD/G) hybrid nanosheets—was designed synthesized for sensitive detection hydrogen peroxide (H2O2). NS-GQD/G was prepared through two steps. First, dots (GQDs) were self-assembled on nanoplatelets via hydrothermal treatment to constitute nanosheets, followed by thermal annealing procedure using the nanosheets thiourea form nanosheets. This material possessed high...
Porous Co3O4 nanoplates were synthesized via a soft template method. By using amphiphilic block copolymer F127 colloids as the pore producer, porous Co(OH)2 prepared. After annealing procedure, obtained reserved hexagonal shape and similar size to precursor. The as-prepared named Co3O4-F simultaneously possessed peroxidase catalase mimetic activities. Interestingly, these two kinds of enzyme activities could be switched by pH. Meanwhile, temperature concentrations had significant effect on...
The rising in situ chemical oxidation (ISCO) technologies based on polymerization reactions have advanced the removal of emerging contaminants aquatic environment. However, despite their promise, uncertainties persist regarding effectiveness eliminating structurally complex contaminants, such as sulfonamide antibiotics (SAs). This study elucidated that oligomerization, rather than mineralization, predominantly governs SAs carbon materials/periodate system. amine groups played a crucial role...