A5101998559- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Adipokines, Inflammation, and Metabolic Diseases
- GDF15 and Related Biomarkers
- Cardiac Fibrosis and Remodeling
- Music and Audio Processing
- Cancer Genomics and Diagnostics
- Blood properties and coagulation
- Inflammasome and immune disorders
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- PARP inhibition in cancer therapy
- Inflammatory Biomarkers in Disease Prognosis
- Renal Diseases and Glomerulopathies
- Reconstructive Surgery and Microvascular Techniques
- Biological and pharmacological studies of plants
- Macrophage Migration Inhibitory Factor
- Reproductive Biology and Fertility
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- Nuclear Receptors and Signaling
Ruijin Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Union Hospital
2013-2024
Huazhong University of Science and Technology
2013-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Baise University
2024
Union Hospital
2023
Shihezi University
2015-2022
Institute of Laboratory Animal Science
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
Abstract Background Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and closely related to cirrhosis. Previous studies have focussed on pathogenesis cirrhosis developing into HCC, but molecular mechanism remains unclear. The aims present study were identify key genes transformation explore associated mechanisms. Methods GSE89377, GSE17548, GSE63898 GSE54236 mRNA microarray datasets from Gene Expression Omnibus (GEO) analysed obtain differentially expressed (DEGs)...
Abstract Background Metabolic syndrome (MetS) is characterized by a cluster of signs metabolic disturbance and has caused huge burden on the health system. The study aims to explore prevalence characteristics MetS defined different criteria in Chinese population. Methods Using data China Hypertension Survey (CHS), nationally representative cross-sectional from October 2012 December 2015, total 28,717 participants aged 35 years above were included analysis. definitions International Diabetes...
Network control theory (NCT) has recently been utilized in neuroscience to facilitate our understanding of brain stimulation effects. A particularly useful branch NCT is optimal control, which focuses on applying theoretical and computational principles design strategies achieve specific goals neural processes. However, most existing research optimally controlling network dynamics from the original state a target at time point. In this paper, we present first investigation introducing...
Abstract Background Serum levels of silent information regulator 6 (SIRT6), a key biomarker aging, were identified as predictor coronary artery disease (CAD), but whether SIRT6 can distinguish severity lesions in older adult patients is unknown. Objectives This study developed nomogram to demonstrate the functionality assessing atherosclerosis. Methods Patients aged 60 years and with angina pectoris screened for this single-center clinical between October 1, 2022, March 31, 2023. specimens...
Objective Complement C1q tumor necrosis factor-related proteins (CTRPs), belonging to the CTRP superfamily, are extensively involved in regulating metabolism and immune-inflammatory response. The inflammatory process is linked pathogenesis of coronary artery disease (CAD). Here, we investigated association serum levels CTRP1 with CAD. Methods Study participants were divided into two groups according results angiography: a control group (n = 63) CAD 76). concentrations cytokines determined by...
Immunotherapy has developed rapidly and gradually become one of the important methods for treatment gastric cancer (GC). The research on tumor infiltrating immune cells (TIICs) immune-related genes in microenvironment (TME) greatly encourages development immunotherapy. devolution algorithm (CIBERSORT) was applied to infer proportion 22 TIICs based gene expression profiles GC tissues, which were downloaded from TCGA GEO. utilized analyze differential genes, explore potential molecular...
Myocardial injuries in viral myocarditis (VMC) are caused by infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune responses addition to allergic diseases. However, the role of VMC remains controversial uncertain. In this study, we infected Balb/c mice with Coxsackievirus B3 (CVB3), found was enriched blood hearts on days 5 7 after virus infection. Most secreted CD8 + T cells day CD4 myocardium. Further, knockout exacerbated cardiac...
Triclosan (TCS) is an endocrine-disrupting chemical (EDC), which used ubiquitously as antimicrobial ingredient in healthcare products and causes contamination the environment such air, water, biosolid-amended soil. Exposure to TCS may increase risk of reproduction diseases health issues. Several groups, including ours, have proved that increased biosynthesis steroid hormones different types steroidogenic cells. However, precise mechanism toxic action on steroidogenesis at a molecular level...
Sacubitril/valsartan (Sac/Val) is a recently approved drug that commonly used for treatment of heart failure. Several studies indicated Sac/Val also regulated the secretion inflammatory factors. However, effect and mechanism this modulation immune responses are uncertain. In study, an experimental autoimmune myocarditis (EAM) mouse model was established by injection α-myosin-heavy chain peptides. The oral on EAM evaluated histological staining tissues, measurements cardiac troponin T markers...
Aims: Th17 cells contributed to myocardial inflammatory injury in acute viral myocarditis (AVMC), and the migration of these were mainly mediated by CCL20-secreting cells. However, whether how resident such as cardiomyocytes cardiac fibroblasts could mediate cell into heart remains unclear AVMC. Methods: The effect CCL20 on dynamic alterations intracardiac disease severity investigated through neutralization AVMC mice. key releasing effects arrest, differentiation detected vitro. Results:...
Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) diverse biological influences on the cardiovascular system. CTRP 3 is a member of superfamily, which may play pivotal role in pathogenesis coronary artery disease (CAD). Here, we investigated whether serum levels are associated with prevalence and severity CAD. In this study, 145 eligible participants were included who underwent angiography. According to result angiography, all divided into...
Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ganoderma lucidum (GL) containing triterpenes and polysaccharides has been shown to have anti-aging properties. In the current study, effects of GL on mating ability, testosterone secretion, testicular structure function were observed middle-aged mice. The was administered orally mice for 2 5 months, then behavioral, serological, histopathological...
BACKGROUND Platelets for transfusion become senescent and dysfunctional during storage, resulting in a markedly short shelf life (5 days). We hypothesized that oxidative stress might account this decline. STUDY DESIGN AND METHODS Human platelets were treated with or without antioxidants before samples collected analyzed at different time points. Platelet senescence was determined by senescence‐associated β‐galactosidase assay, senescence‐related platelet qualities also analyzed. RESULTS Sign...
Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis. Moreover, some recent studies have reported an association between GDF-15 platelet activation. In this study, we isolated peripheral blood platelets from healthy volunteers evaluated the effect of on adenosine diphosphate (ADP)-induced activation using aggregation assay. Subsequently, detected expression GDF-15-related receptors...
B10 cells are generally considered to inhibit the kidney injury in systemic lupus erythematosus (SLE) mouse models, but recently this function of was denied by lineage-specific deletion IL-10 from B cells. Thus, study aimed determine whether and how play a protective role nephritis (LN). LN non-LN SLE patients without receiving any treatments were recruited, percentages circulating cell determined. Furthermore, purified transferred into MRL/lpr mice, exact effects on progression...
To observe the effects of moxibustion on Treg/Th17 imbalance and related signal pathway in mice with rheumatoid arthritis (RA), so as to explore action mechanism RA.Twenty-four DBA/1J male were randomly divided into a normal group, model sham group 6 each one. RA was induced by subcutaneous injection typeⅡcollagen adjuvant at tail other than group. The treated at"Zusanli" (ST 36) "Shenshu" (BL 23), 1 mg per cone, cones acupoint. consecutive 6-day treatment taken one course, totally 2 courses...