A5000248061- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Renin-Angiotensin System Studies
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trace Elements in Health
- Adipose Tissue and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heat shock proteins research
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Receptor Mechanisms and Signaling
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Medical University
2016-2025
Fujian Provincial Hospital
2022-2025
First Affiliated Hospital of Shantou University Medical College
2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2019-2024
University of Gondar
2024
Regional Medical Center
2024
Xiamen University
2007-2024
First Affiliated Hospital of Xiamen University
2024
Abstract Sarcopenia has become a leading cause of disability and mortality in the elderly. It been reported that programmed cell death (PCD) is associated with development sarcopenia characterized by reduction muscle fiber size number. TNF-α also validated to play prominent role through its complex signaling pathways including signaling. However, it still unclear whether contributes mediating pyroptosis, one type PCD. Here, we first established naturally aged mice model confirmed an...
Pulmonary arterial hypertension (PAH) was a devastating disease characterized by artery remodeling, ultimately resulting in right heart failure. The aim of this study to investigate the effects canagliflozin (CANA), sodium-glucose cotransporter 2 inhibitor (SGLT2i) with mild SGLT1 inhibitory effects, on rats PAH, as well its direct impact pulmonary smooth muscle cells (PASMCs). PAH were induced injection monocrotaline (MCT) (40 mg/kg), followed four weeks treatment CANA (30 mg/kg/day) or...
Inflammation and immunity play a causal role in the pathogenesis of pulmonary vascular remodelling arterial hypertension (PAH). However, pathways mechanisms by which inflammation contribute to remain unknown. RNA sequencing was used analyse transcriptome control rats injected with monocrotaline (MCT) for various weeks. Using transcriptional profiling MCT-induced PAH coupled bioinformatics analysis, we clustered differentially expressed genes (DEGs) chose increased expression patterns...
Abstract Background Metabolic syndrome (MetS) is characterized by a cluster of signs metabolic disturbance and has caused huge burden on the health system. The study aims to explore prevalence characteristics MetS defined different criteria in Chinese population. Methods Using data China Hypertension Survey (CHS), nationally representative cross-sectional from October 2012 December 2015, total 28,717 participants aged 35 years above were included analysis. definitions International Diabetes...
The zinc transporter ZIP12 is a membrane-spanning protein that transports ions into the cytoplasm from extracellular space. Recent studies demonstrated upregulation of involved in elevation cytosolic free and excessive proliferation pulmonary arterial smooth muscle cells (PASMCs) induced by hypoxia. However, expression its role hypertension (PAH) monocrotaline (MCT) rats have not been evaluated previously. aim this study was to investigate effect on migration PASMCs underlying mechanisms...
Metal responsive transcription factor 1 (MTF-1) is a zinc-dependent involved in the development of pulmonary arterial hypertension (PAH), which life-threatening disease characterized by elevated artery pressure and vascular remodeling. However, little known about role regulatory signaling MTF-1 PAH. This study aimed to investigate effect mechanism on proliferation smooth muscle cells (PASMCs). Several techniques including intracellular-free zinc detected fluorescent indicator-fluozinc-3-AM,...
Red blood cell distribution width (RDW) has recently been recognized as a novel biomarker associated with various cardiovascular conditions. This study aims to investigate the relationship between RDW and carotid-femoral pulse wave velocity (cfPWV) in southern Chinese population. A total of 4916 patients were initially enrolled from First Affiliated Hospital Fujian Medical University January 2016 December 2022. Based on criteria inclusion exclusion, 2830 included this study. Body weight,...
Abstract Background The triadic relationship among the number of NCDs, preventive behaviors and health beliefs has not been fully explored, especially role beliefs. Aims To explore association between NCDs behaviors, as well mediating effect its dimensions middle-aged older adults. Provide scientific evidence for developing targeted behavior intervention. Methods Data from 2095 adults who completed demographic information, questionnaire. Mediation analysis was used to behaviors. Results...
Muscle atrophy is a severe complication of diabetes, with autophagy playing critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes-related complications, but direct mediating diabetic muscle remains unclear. This study explores the potential zinc pathogenesis atrophy. In vivo, C57BL/6J mice were induced diabetes by streptozotocin (STZ) treated ZnSO₄ (25 mg/kg/day) for six weeks. Gastrocnemius muscles collected histological analysis, including...
Over 95% of Belgian Blue (BB) cows deliver via elective cesarean section (CS). The aim this study was to determine the effect CS on incidence subclinical endometritis (SCE) using cytobrush (CB) and low-volume lavage (LVL) techniques evaluate sensitivity both in detecting SCE. Uteri BB (n = 100) were collected from slaughterhouse. Cytobrush samples followed by LVL cytology all uterine horns 200). CB rolled a microscope slide while centrifuged, pelleted cells then scattered over slide. In...
Background Pulmonary arterial hypertension (PAH) is a severe disease marked by the remodeling of arteries due to abnormal growth vascular cells, including pulmonary smooth muscle cells (PASMCs). The insulin receptor substrate-1 (IRS-1) plays crucial role in signaling pathway; however, its function PAH still not fully understood. objective this research was explore protein kinase C (PKC)/IRS-1/ERK pathway progression and influence on proliferation migration PASMCs. Methods To establish model,...
Gastric schwannoma (GS) is often misdiagnosed as gastrointestinal stromal tumors due to the high incidence of latter. However, these two types differ significantly in pathology and biological behavior. To evaluate computed tomography characteristics GS provide insights into its accurate diagnosis. Twenty-three cases confirmed between January 2011 December 2023 were assessed clinically radiologically. Imaging characteristics, including tumor location, size, contour, ulceration, growth...
The aim of this study is to investigate the effects subchronic exposure carbendazim on spermatogenesis and fertility in male rats. Ninety-eight healthy rats were divided into four groups: three groups a control group. Carbendazim was administered orally at 0, 20, 100 200 mg/kg for 80 days prior mating. Each cohabited with an unexposed female maximum 5 days. In groups, mating index relatively increased, decreased, testis weight, sperm counts motility also decreased. levels luteinizing hormone...
Abstract The level of lactate dehydrogenase (LDH) has been proved to be positively associated with albuminuria, which represents glomerular endothelial damage in hypertension (HTN). In this study, the relationship between LDH and function evaluated by flow-mediated dilation (FMD) was investigated hypertensives. 1507 subjects (aged 61.2 ± 12.5 years) were enrolled. All hypertensives (n = 1216) subdivided into 3 groups: LDH1 (lowest tertile LDH, n 399), LDH2 (mediate 409) LDH3 (highest 408)....
Abstract Nocturnal hypertension is highly prevalent among Chinese and Asian populations, which mainly attributed to high salt intake sensitivity. increases the risk of cardiovascular all‐cause mortality, independent daytime blood pressure (BP). However, it can usually be detected by 24‐h ambulatory BP monitoring, rather than routine office or home measurement, thus often underdiagnosed in clinical practice. Currently, no specific guidance available for management nocturnal China worldwide....
Both hypertension and type 2 diabetes are attributable to premature death, cardiovascular kidney diseases with largely overlapping population. Followed the GRADE approach, this expert consensus aimed reduce death disability due minimize treatment burden in adults diabetes. Through online survey discussion, a multidisciplinary team comprehensively prioritized seven key guideline questions. Informed by evidence synthesis developed 12 recommendations under Evidence-to-decision (EtD) framework....
AbstractStructural remodeling of pulmonary artery plays an important role in maintaining sustained arterial hypertension (PAH). The anti-remodeling effects statins have been reported systemic hypertension. In this study, we studied the atovastatin (Ato) or losartan (Los) monocrotaline (MCL)-induced using a rat model. Forty Sprague-Dawley (SD) rats were randomly assigned into four groups (n == 10): normal control (Ctr), PAH, PAH treated with Los, and Ato. We found that Los- Ato-treated group,...
The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and underlying cellular molecular mechanisms. ADSCs were successfully isolated from characterized. effectively infected green fluorescent protein (GFP)-empty (ADSCs-V) or APN-GFP (ADSCs-APN) lentivirus APN expression was evaluated by ELISA. Sprague-Dawley administered monocrotaline (MCT) develop PAH. treated MCT,...
Microalbuminuria is a risk factor for cardiovascular morbidity and mortality in hypertensive patients. However, the relationship between low-grade albuminuria, higher level of albuminuria below microalbuminuria threshold, hypertension-related organ damage unclear. Left ventricular (LV) hypertrophy (LVH) well recognized to be subclinical hypertension, LV diastolic dysfunction also reported an early functional cardiac change hypertension that predicts heart failure. The present study aimed...
Pulmonary arterial hypertension (PAH) is a serious disease characterized by elevated pulmonary artery pressure, inflammatory cell infiltration and vascular remodeling.However, little known about the pathogenic mechanisms underlying onset progression.RNA sequencing (RNA-seq) was used to identify transcriptional profiling in control rats injected with monocrotaline (MCT) for 1, 2, 3 4 weeks.A total of 23200 transcripts 280, 1342, 908 3155 differentially expressed genes (DEGs) were identified...