A5029766671- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Sodium Intake and Health
- Diabetes Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Ion Channels and Receptors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes and associated disorders
- Gastric Cancer Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Olfactory and Sensory Function Studies
- Cardiovascular Health and Disease Prevention
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Ion Transport and Channel Regulation
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Adrenal Hormones and Disorders
- Acute Ischemic Stroke Management
- Regulation of Appetite and Obesity
Daping Hospital
2016-2025
Army Medical University
2016-2025
Ningxia Medical University
2025
Shantou University Medical College
2025
Shantou University
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Shanghai Institute of Hypertension
2020-2024
Third Xiangya Hospital
2023
Central South University
2023
Non-insulin-dependent diabetes mellitus (NIDDM) is a genetically heterogeneous disorder. Maturity-onset of the young, form NIDDM with an early age onset and autosomal dominant inheritance, can result from mutations in glucokinase, key enzyme glucose metabolism beta cells liver. We studied 32 French families maturity-onset young as well 21 late-onset to determine frequency clinical features glucokinase. Fasting plasma concentrations oral glucose-tolerance tests were used metabolic status. DNA...
The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations human gene are a common cause autosomal dominant form non-insulin-dependent (type 2) diabetes mellitus (NIDDM) has onset often during childhood. majority been identified missense result synthesis molecule with altered amino acid sequence. To characterize effect these on catalytic properties beta-cell glucokinase, we expressed native mutant forms this...
Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to lower blood pressure (BP) in hypertensive animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs human hypertension or prehypertension, a key stage development hypertension. In randomized, double-blind, placebo-controlled study, we assessed effects intervention on BP and vascular function prehypertension. We randomly assigned 120 eligible...
The whitening and loss of brown adipose tissue (BAT) during obesity aging promote metabolic disorders related diseases. imbalance Ca2+ homeostasis accounts for the dysfunction clearance mitochondria BAT whitening. Capsaicin, a dietary factor activating TRPV1, can inhibit induced by high-fat diet (HFD), but whether capsaicin inhibits underlying mechanism remain unclear. In this study, we determined that inhibitory effects on HFD-induced were dependent participation SIRT3, critical...
High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high associated with nonalcoholic fatty liver disease, which an independent diseases, it remains elusive whether salt-induced hepatic damage leads to development of diseases.Mice were fed normal or high-salt diet 8 weeks determine effect loading on histological changes and blood pressure, withdrawal metformin treatment also conducted some diet-fed mice. Adeno-associated...
High salt intake is a major risk factor for hypertension and associated with cardiovascular events. Most countries exhibit traditionally high intake; thus, identification of an optimal strategy reduction at the population level may have impact on public health. In this multicenter, random-order, double-blind observational interventional study, subjects spice preference had lower blood pressure than who disliked spicy food. The enjoyment flavor enhanced sensitivity reduced preference. Salt...
Coronary heart disease arising from atherosclerosis is a leading cause of cardiogenic death worldwide. Mitochondria are the principal source reactive oxygen species (ROS), and defective oxidative phosphorylation by mitochondrial respiratory chain contributes to ROS generation. Uncoupling protein 2 (UCP2), an adaptive antioxidant defense factor, protects against ROS-induced endothelial dysfunction in atherosclerosis. The activation transient receptor potential vanilloid 1 (TRPV1) attenuates...
Abstract Patients with cardiometabolic risk factors and asymptomatic cardiac hypertrophy are hallmarks of early-stage heart failure (HF). We hypothesized that mitochondrial respiratory dysfunctions peripheral blood mononuclear cells (PBMCs) may be associated inflammation oxidative stress in HF patients complicated factors. Totally 49 subjects were enrolled 25 (stages A B) having dysfunction 24 healthy controls. It showed excessive reduced antioxidant capacity closely abnormalities patients....
Background Patients with hypertension and diabetes mellitus are susceptible to dementia, but regular therapy fails reduce the risk of dementia. Glucagon-like peptide-1 receptor agonists have neuroprotective effects in experimental studies. We aimed assess effect liraglutide, a glucagon-like agonist, on cognitive function whether its was associated metabolic changes patients type 2 mellitus. Methods Results Fifty were recruited this prospective study. All underwent assessment brain activation...
Abstract Background It is necessary to analyze the characteristics and risk factors of catheter-related bloodstream infection (CRBSI) in newborns with peripherally inserted central catheter (PICC). Methods Newborns undergoing PICC catheterization neonatal department our hospital from January 1, 2020 31, 2021 were included. The without CRBSI compared analyzed. Logistic regression analyses performed evaluate PICC. Results Three hundred eighty-six included, whom 41 had CRBSI, incidence was...
Excess salt intake is not only an independent risk factor for heart failure, but also one of the most important dietary factors associated with cardiovascular disease worldwide. Metabolic reprogramming in cardiomyocytes early event provoking cardiac hypertrophy that leads to subsequent events upon high loading. Although SGLT2 inhibitors, such as canagliflozin, displayed impressive health benefits, whether inhibitors protect against hypertrophy-related metabolic loading remain elusive. To...
Roux-en-Y gastric bypass (RYGB) results in glucose-lowering patients with type 2 diabetes mellitus (T2DM) and may be associated increased intestinal glucose excretion. However, the contribution of excretion to glycemic control after RYGB its underlying mechanisms are not fully elucidated. Here, we confirmed that significantly obese rats RYGB, which was negatively correlated postoperative blood levels. Moreover, also found Biliopancreatic limb length, an important factor affecting improvement...
Mutations in the glucokinase gene are a major cause of maturity-onset diabetes young. To evaluate contribution this to development late-onset NIDDM, linkage analyses between DNA polymorphisms at locus and NIDDM were performed 79 multigenerational French families. In addition, all exons islet promoter region from 1 affected member each family as well 17 unrelated women with previous gestational amplified by polymerase chain reaction screened for mutations single-strand conformational...
High salt intake is one independent risk factor for cardiac hypertrophy. Polycystic kidney disease 2-like 1 (PKD2L1, also called TRPP3) acts as a sour sensor in taste cells, and its possible role the cardiovascular system unknown. Here, we report that knockout of PKD2L1 exacerbated high-salt diet (HSD)-induced hypertrophy fibrosis, accompanied by dysfunction reduced mitochondrial oxidative phosphorylation enzyme activity. Furthermore, knockdown led to more serious Ca2+ overload uptake...
Abstract Primary aldosteronism (PA) is associated with resistant hypertension and cardiovascular events. There are some limitations of current medical surgical therapies for PA. To determine the efficacy safety catheter‐based adrenal artery ablation treatment PA patients who refused both surgery therapy, we performed this prospective cohort study. Thirty‐six without apparent aldosteronoma were treated by ablation. outcome was postoperative blood pressure defined daily dose (DDD)...
Background Salt-sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that SGLT2 (sodium-glucose cotransporter 2) inhibitors exert hypotensive effect protective benefits in patients without diabetes. However, the underlying mechanism remains elusive. Methods Results Dahl salt-sensitive rats salt-insensitive controls were fed 8% high-salt diet some of them treated canagliflozin. The blood pressure, urinary sodium excretion,...