A5010773888- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Body Contouring and Surgery
- Digestive system and related health
- Genetics and Neurodevelopmental Disorders
- Advanced Glycation End Products research
- Regulation of Appetite and Obesity
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Obesity and Health Practices
- Hormonal Regulation and Hypertension
- Advanced Chemical Sensor Technologies
- Genetic Mapping and Diversity in Plants and Animals
University of Lausanne
2016-2025
University Hospital of Lausanne
2014-2024
Inserm
1994-2011
Sorbonne Université
2006-2011
Institut National de Recherche en Santé Publique
1996-2007
Centre National de Recherche en Génomique Humaine
2002-2004
Institut Pasteur de Lille
1995-2000
Centre National de la Recherche Scientifique
1998-2000
Institut Pasteur
1998
Centre National pour la Recherche Scientifique et Technique (CNRST)
1997
Non-insulin-dependent diabetes mellitus (NIDDM) is a genetically heterogeneous disorder. Maturity-onset of the young, form NIDDM with an early age onset and autosomal dominant inheritance, can result from mutations in glucokinase, key enzyme glucose metabolism beta cells liver. We studied 32 French families maturity-onset young as well 21 late-onset to determine frequency clinical features glucokinase. Fasting plasma concentrations oral glucose-tolerance tests were used metabolic status. DNA...
Pancreatic beta-cell function was studied in six subjects with mutations the enzyme glucokinase (GCK) who were found to have elevated fasting and postprandial glucose levels comparison normoglycemic controls. Insulin secretion rates (ISRs) estimated by deconvolution of peripheral C-peptide values using a two-compartment model individual kinetics obtained after bolus intravenous injections biosynthetic human C-peptide. First-phase insulin secretory responses over 24-h period on weight...
DNA polymorphisms in the glucokinase gene have recently been shown to be tightly linked early-onset non-insulin-dependent diabetes mellitus approximately 80% of French families with this form diabetes. We previously identified a nonsense mutation exon 7 one these and showed that it was likely cause glucose intolerance dominantly inherited disorder. Here we report isolation partial sequence human identification two missense mutations 7, Thr-228----Met Gly-261----Arg, cosegregate mellitus. To...
The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations human gene are a common cause autosomal dominant form non-insulin-dependent (type 2) diabetes mellitus (NIDDM) has onset often during childhood. majority been identified missense result synthesis molecule with altered amino acid sequence. To characterize effect these on catalytic properties beta-cell glucokinase, we expressed native mutant forms this...
Probiotic yogurt and milk supplemented with probiotics have been investigated for their role in 'low-grade' inflammation but evidence efficacy is inconclusive. This study explores the impact of probiotic on metabolic inflammatory biomarkers, a parallel gut microbiota dynamics. The randomised cross-over was conducted fourteen healthy, young men to test compared acidified 2 % d-(+)-glucono-δ-lactone during 2-week intervention (400 g/d). Fasting assessments, high-fat meal (HFM) analyses were...
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel postpubertal decrease hypothalamic as well extrahypothalamic expression of master molecule controls reproduction-gonadotropin-releasing hormone (GnRH)-and appear related to an imbalance microRNA-gene network known regulate GnRH neuron maturation together with altered...
Brief summary: This study identified a new role for GnRH in higher brain function using rodent model of Down Syndrome. It reports the first time an improvement cognitive functions patients with Syndrome treated pulsatile GnRH.
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted by the endocrine K-cells from duodenum that stimulates glucose-induced insulin secretion. Here, we present molecular characterization of human pancreatic islet GIP receptor. cDNA clones for receptor were isolated library. They encoded two different forms receptor, which differed 27–amino acid insertion in COOH-terminal cytoplasmic tail. The protein sequence was 81% identical to rat When expressed Chinese hamster lung...
The measurement of food intake biomarkers (FIBs) in biofluids represents an objective tool for dietary assessment. FIBs milk and cheese still need more investigation due to the absence candidate markers. Thus, acute intervention study has been performed sensitively specifically identify FIBs. Eleven healthy male female volunteers participated randomized, controlled crossover that tested a single as test products, soy-based drink control. Urine samples were collected at baseline up 24 h...
Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogeneous disorder characterized by hyperglycemia resulting from defects in insulin secretion and action. Recent studies have found mutations the hepatocyte nuclear factor-4 alpha gene (HNF-4alpha) families with maturity-onset of young (MODY), an autosomal dominant form early age at onset defect glucose-stimulated secretion. During course our search for susceptibility genes contributing to more common late-onset NIDDM forms, we...
An A-to-G transition in the mitochondrial tRNALeu(UUR) gene at base pair 3243 has been shown to be associated with maternally transmitted clinical phenotype of NIDDM and sensorineural hearing loss white Japanese pedigrees. We have detected this mutation 25 50 tested members five French Affected (mutation-positive) family presented variable features, ranging from normal glucose tolerance (NGT) insulin-requiring diabetes. The present report describes phenotypes affected detailed evaluations...
Recent studies have shown that mutations in the glucokinase gene on chromosome 7 can cause an autosomal dominant form of NIDDM with a variable clinical phenotype and onset during childhood. The includes mild fasting hyperglycemia (i.e., plasma glucose value > 110 mg/dl, is at least 2–3 SDs above normal), impaired tolerance, gestational diabetes mellitus, as well overt defined using National Diabetes Data Group or World Health Organization criteria. Because mellitus was feature...
Fermentation is a widely used method of natural food preservation that has consequences on the nutritional value transformed food. Fermented dairy products are increasingly investigated in view their ability to exert health benefits beyond qualities. To explore mechanisms underpinning fermented intake, present study followed effects milk fermentation, from changes product metabolome human serum after its ingestion. A randomized crossover design was conducted 14 healthy men [mean age: 24.6 y;...
Adipose tissue plasticity is orchestrated by molecularly and functionally diverse cells within the stromal vascular fraction (SVF). Although several mouse human adipose SVF cellular subpopulations have now been identified, we still lack an understanding of functional variability stem progenitor cell (ASPC) populations across fat depots. To address this, performed single-cell bulk RNA sequencing (RNA-seq) analyses >30 SVF/Lin- samples four depots, revealing two ubiquitous ASPC (hASPC) with...
Abstract Background Obesity is associated with varying degrees of metabolic dysfunction. In this study, we aimed to discover markers the severity impairment in men obesity via a multiomics approach. Methods Thirty-two morbidly who were candidates for Roux-en-Y gastric bypass (RYGB) surgery prospectively followed. Nine healthy adults served as controls. Deep phenotyping, including targeted metabolomics, transcriptomics, and brain magnetic resonance imaging (MRI), was performed. Results...
Abstract Despite major progress in understanding the impact of triplicated chromosome 21 on brain and behaviour Down syndrome, our knowledge underlying neurobiology humans is still limited. We sought to address some pertinent questions about drivers structure differences their associations with cognitive function syndrome. To this aim, a pilot magnetic resonance imaging (MRI) study, we monitored anatomy individuals syndrome receiving pulsatile gonadotropin-releasing hormone (GnRH) therapy...
The sulfonylurea receptor (SUR) is a key component in glucose-stimulated insulin secretion. Obesity and NIDDM are frequently associated share some metabolic abnormalities, suggesting that they might also susceptibility genes. Thus, the SUR encoding gene plausible candidate for primary pancreatic β-cell defect thus hyperglycemia weight gain. Through association linkage studies, we have investigated potential role of families with two independent sets morbidly obese families. exon 22 T-allele...
Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found rat models type 2 diabetes and hypertension diabetic patients. We investigated influence nucleotide variation on components metabolic syndrome. Following comprehensive resequencing gene, we genotyped 12 informative polymorphisms 1,304 individuals from 424 British families that were characterized for...