Isabel Paiva
A5031298837- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Parathyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ovarian function and disorders
- Myasthenia Gravis and Thymoma
- Bone health and treatments
- Parkinson's Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Nuclear Receptors and Signaling
- Blood disorders and treatments
- Vitamin D Research Studies
- Bariatric Surgery and Outcomes
Hospitais da Universidade de Coimbra
2015-2024
Laboratoire de Neurosciences Cognitives et Adaptatives
2020-2024
Université de Strasbourg
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Universidade Estadual de Londrina
2024
Sociedade Portuguesa de Cardiologia
2024
University of Coimbra
2023
Centre for Biomedical Network Research on Rare Diseases
2023
Instituto de Salud Carlos III
2023
Hospital Universitari Germans Trias i Pujol
2023
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of age. PCOS has a strong heritable component, but its pathogenesis been unclear. Here, we performed RNA sequencing genome-wide DNA methylation profiling ovarian tissue from control third-generation PCOS-like mice. We found that hypomethylation regulates key genes associated with several differentially methylated are also altered in blood samples compared healthy controls. Based on this...
Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise molecular mechanisms underlying its pathogenicity remain unclear. It has recently been suggested that nuclear aSyn may modulate gene expression, possibly via interactions with DNA. However, biological behavior of nucleus and factors affecting transcriptional role are not known. Here, we investigated aSyn-mediated transcription deregulation by assessing effects impact phosphorylation these dynamics. We...
Alpha-synuclein (aSyn) is considered a major culprit in Parkinson's disease (PD) pathophysiology. However, the precise molecular function of protein remains elusive. Recent evidence suggests that aSyn may play role on transcription regulation, possibly by modulating acetylation status histones. Our study aimed at evaluating impact wild-type (WT) and mutant A30P gene expression, dopaminergic neuronal cell model, decipher potential mechanisms underlying aSyn-mediated transcriptional...
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel postpubertal decrease hypothalamic as well extrahypothalamic expression of master molecule controls reproduction-gonadotropin-releasing hormone (GnRH)-and appear related to an imbalance microRNA-gene network known regulate GnRH neuron maturation together with altered...
Caffeine is the most widely consumed psychoactive substance in world. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed mechanisms associated with habitual (chronic) caffeine mouse hippocampus using untargeted orthogonal omics techniques. Our results revealed that chronic exerts concerted pleiotropic effects at epigenomic, proteomic, and metabolomic levels. lowered metabolism-related processes (e.g., level of metabolomics gene expression)...
Brief summary: This study identified a new role for GnRH in higher brain function using rodent model of Down Syndrome. It reports the first time an improvement cognitive functions patients with Syndrome treated pulsatile GnRH.
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (<65...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
A vacinação de cães e gatos é uma estratégia crucial para prevenir doenças infecciosas proteger a saúde pública. Enfermidades como raiva, leptospirose, leishmaniose, cinomose parvovirose podem ser evitadas com vacinas amplamente recomendadas, antirrábica, V8/V10 V4 gatos. Apesar das campanhas anuais promovidas pelo Ministério da Saúde, cobertura vacinal no Brasil ainda insuficiente, índices abaixo meta 80%, especialmente em regiões rurais periféricas. Elementos acesso restrito serviços...
A contenção química em pequenos felinos silvestres, utilizando a associação de dexmedetomidina e cetamina, é uma prática eficaz que garante sedação profunda, analgesia estabilidade hemodinâmica durante procedimentos clínicos cirúrgicos. Este estudo analisou literatura acerca das consequências dessa combinação diversas espécies, tais como jaguatiricas gatos-do-mato. utilização desses medicamentos resultou um tempo indução rápido recuperação segura, com possibilidade reverter o processo uso...
Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into European Registry on (ERCUSYN) to evaluate if patients CS pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than adrenal causes (ADR-CS). Data from 595 (492 women; 83%) who completed CushingQoL and/or EQ-5D questionnaires at baseline following were analysed. At baseline, HRQoL did not...
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Human Papillomavirus cause a number of diseases most notably cervical cancer. K14-HPV16 transgenic mice expressing the HPV16 early genes in squamous epithelial cells provide suitable experimental model for studying these diseases. MicroRNAs are small non-coding RNAs that play an important role regulating gene expression and have been suggested to cancer development. The miR-155 remains controversial there is limited evidence linking this miRNA HPV- associated We hypothesized modulates each...
Abstract Adenosine A 2A receptors (A R) are modulators of various physiological processes essential for brain homeostasis and fine synaptic tuning. In certain neurodegenerative conditions, notably Alzheimer's disease (AD), Rs pathologically upregulated in neurons but also astrocytes. that context, the use inhibitors, normalizing impaired receptor function, is seen as a potential therapeutic strategy. However, impact R alterations, particularly astrocytes, not fully understood. Here, we...
Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to aSyn aggregation and accompanied transcript deregulation. Objective: We sought identify microRNAs associated with synaptic processes that may contribute dysfunction degeneration synucleinopathies. Methods: performed small RNA-sequencing midbrain from 6-month-old transgenic mice expressing A30P mutant aSyn, followed...
Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations a contributing factor. Here, we compared transcriptomic/epigenomic changes in hippocampus, modified by aging and tauopathy, an AD-related feature. We show that cholesterol biosynthesis pathway severely impaired hippocampal neurons tauopathic but not aged mice pointing to vulnerability these disease. At epigenomic level, histone hyperacetylation was observed at...
Parkinson's disease is the second most prevalent neurodegenerative disorder. The main neuropathological hallmarks of are degeneration dopaminergic neurons in substantia nigra pars compacta and accumulation protein inclusions known as Lewy bodies. Recently, great attention has been given to study genes associated with both familial sporadic forms disease. Among them, α-synuclein gene believed play a central role is, therefore, one studied genes. complex disorder and, such, derives from...
In rats, learning and memory performance decline during normal aging, which makes this rodent species a suitable model to evaluate therapeutic strategies. aging insulin-like growth factor-I (IGF-I), is known significantly improve spatial accuracy as compared control counterparts. A constellation of gene expression changes underlie the hippocampal phenotype but no studies on effects IGF-I transcriptome old rodents have been documented. Here, we assessed therapy in female rats them with...
Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by accumulation aggregated proteins and increase in oxidative stress markers. Here, we used non-invasive bimolecular fluorescence complementation (BiFC) assay human H4 cells to investigate kinetics aggregation subcellular localization Sod1 mutants. We also studied effect different mutants respond against following levels reactive oxygen species...
Abstract Context Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20%, and adverse drug effects are frequent. To date, there no marker established that predicts treatment response. Mitotane has been shown inhibit sterol-O-acyl transferase 1 (SOAT1), which leads endoplasmic reticulum stress cell death ACC cells. investigate SOAT1 protein expression as a of mitotane. Patients A total 231 patients treated with single-agent adjuvant (n = 158) or...