A5055028996- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Cardiac tumors and thrombi
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Stress Responses and Cortisol
- Pancreatic and Hepatic Oncology Research
- Ophthalmology and Eye Disorders
- Sarcoma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Thyroid and Parathyroid Surgery
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Cannabis and Cannabinoid Research
- Neurofibromatosis and Schwannoma Cases
Hôpital Cardiologique du Haut-Lévêque
2016-2025
Université de Bordeaux
2016-2025
Inserm
2011-2024
Neurocentre Magendie
2011-2024
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Bordeaux Population Health
2013-2022
NutriNeuro
2021
Galen University
2016
Victor (Japan)
2016
Bicêtre Hospital
2015
: By definition, an adrenal incidentaloma is asymptomatic mass detected on imaging not performed for suspected disease. In most cases, incidentalomas are nonfunctioning adrenocortical adenomas, but may also represent conditions requiring therapeutic intervention (e.g. carcinoma, pheochromocytoma, hormone-producing adenoma or metastasis). The purpose of this guideline to provide clinicians with best possible evidence-based recommendations clinical management patients based the GRADE (Grading...
The objective is to formulate clinical practice guidelines for treating Cushing's syndrome.
Adrenocortical carcinoma is a rare cancer that has poor response to cytotoxic treatment.We randomly assigned 304 patients with advanced adrenocortical receive mitotane plus either combination of etoposide (100 mg per square meter body-surface area on days 2 4), doxorubicin (40 day 1), and cisplatin 3 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g 1 5 in cycle 1; subsequent cycles) weeks. Patients disease progression received the alternative regimen as second-line therapy. The...
AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated adenomas and less often sporadic cases. The clinical therapeutic features of AIPmut-associated have not been studied comprehensively.The objective the study was assess clinical/therapeutic characteristics AIPmut adenomas.This an international, multicenter, retrospective case collection/database analysis.The conducted at 36 tertiary referral endocrine genetics departments.Patients included...
Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons other than suspected disease. In most cases, nonfunctioning adrenocortical adenomas but may also require therapeutic intervention including that carcinoma, pheochromocytoma, hormone-producing adenoma, or metastases. Here, we provide a revision of the first international, interdisciplinary guidelines incidentalomas. We followed Grading Recommendations Assessment, Development and Evaluation system updated...
The use of ketoconazole has been recently questioned after warnings from the European Medicine Agencies and Food Drug Administration due to potential hepatotoxicity. However, is frequently used as a drug lower circulating cortisol levels. Several pharmacological agents have approved for treatment Cushing's disease (CD) despite limited efficacy or significant side effects. Ketoconazole worldwide more than 30 years in CD, but absence large-scale study, its tolerance are still under debate.We...
Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity characteristics. We aimed to validate a urine steroid metabolomics approach, using profiling as the diagnostic basis for ACC.
Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for parameters of overall survival (OS) in MPP patients. Retrospective multicenter study a neck-thoraco-abdomino-pelvic CT or MRI at the time malignancy diagnosis European centers between 1998 2010. One hundred sixty-nine patients from 18 were included. Main characteristics with were: primary 53% patients; tumor- hormone-related symptoms 57% 58% cases; positive plasma...
Background: Benign adrenal tumors are commonly discovered on cross-sectional imaging. Mild autonomous cortisol secretion (MACS) is regularly diagnosed, but its effect cardiometabolic disease in affected persons ill defined. Objective: To determine burden and steroid excretion with benign without MACS. Design: Cross-sectional study. Setting: 14 endocrine secondary tertiary care centers (recruitment from 2011 to 2016). Participants: 1305 prospectively recruited tumors. Measurements: Cortisol...
Subclinical Cushing's syndrome (SCS) caused by adrenal incidentalomas is frequently associated with overweight and insulin resistance. Metabolic X may therefore be a clue to the presence of CS. However, incidence CS in this situation remains unknown. We have conducted prospective study evaluate prevalence occult overweight, type-2 diabetic patients devoided specific clinical symptoms Two hundred patients, consecutively referred for poor metabolic control (HbA(1C) > 8%), were studied as...
Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas.We retrieved 43 consecutive patients with tumors (23 male 20 female) among 4400 adenomas followed between 1976 2001 six Belgian French centers.TSH elevated 18/43 alpha subunit 13/32 patients. In intact thyroid (n=30), mean free tri-iodothyronine 13.1 pmol/l (range 3.5-23) thyroxine 38.4 10.2-62.7). Hyperprolactinemia acromegaly were associated 9/43 8/43 cases. The number hypersecretions...
Chronic exposure to hypercortisolism has significant impact on patient's health and health-related quality of life (HRQoL), as demonstrated with generic questionnaires. We have developed a disease-generated questionnaire evaluate HRQoL in patients Cushing's syndrome (CS; CushingQoL). Objective Validate the CushingQoL CS clinical practice conditions. Design Observational, international, cross-sectional study. Methods A total 125 were recruited by 14 investigators from Spain, France, Germany,...
Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated lesions a large cohort to provide rationale for their management. Methods Analysis records from 715 MEN1 patients multicentre database between 1956 and 2008. Adrenal were compared with those 144 sporadic incidentalomas. Results enlargement was reported 20.4% (146/715) patients. tumours (>10 mm size) accounted 58.1% these cases...
Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HHG). In affected boys, primary insufficiency occurs soon after birth or during early childhood; HHG is recognized at expected time of puberty. this report, we describe novel phenotype a man who presented with apparently isolated 28 years age. Examination revealed partial pubertal development undiagnosed incomplete HHG. Gonadotropin therapy did not improve his marked oligospermia,...
Methodological shortcomings often compromise investigations into the effects of primary somatostatin-analog treatment on tumor size in acromegaly. There are also limited data for long-acting lanreotide formulation.The aim study was to better characterize Autogel patients with GH-secreting macroadenomas.PRIMARYS a 48-week, multicenter, open-label, single-arm study.The conducted at specialist endocrine centers.Treatment-naïve acromegalic macroadenomas participated study.Lanreotide 120 mg...
Multiple endocrine neoplasia Type-1 (MEN1) in young patients is only described by case reports.To improve the knowledge of MEN1 natural history before 21 years old.Obtain a description first symptoms occurring old (clinical symptoms, biological or imaging abnormalities), surgical outcomes related to Neuro Endocrine Tumors (NETs) group 160 extracted from "Groupe d'étude des Tumeurs Endocrines" cohort.The were hyperparathyroidism 122 cases (75%), pituitary adenoma 55 (34%), nonsecreting...
Aryl hydrocarbon receptor interacting protein (AIP) mutations (AIPmut) cause aggressive pituitary adenomas in young patients, usually the setting of familial isolated adenomas. The prevalence AIPmut among sporadic adenoma patients appears to be low; studies have not addressed most clinically relevant population. Hence, we undertook an international, multicenter, prospective genetic, and clinical analysis at 21 tertiary referral endocrine departments.We included 163 macroadenoma irrespective...
Context Germline mutations in the aryl hydrocarbon receptor interacting protein gene ( AIP ) have been identified young patients (age ≤30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning prevalence of multiple endocrine neoplasia type 1 MEN1 such a population. Objective We assessed both and genetic abnormalities (mutations large deletions) diagnosed isolated macroadenoma, without hypercalcemia and/or MEN1-associated lesions. Design The entire coding...
Background The discovery of the endocannabinoid system and its role in regulation energy balance has significantly advanced our understanding physiopathological mechanisms leading to obesity type 2 diabetes. New knowledge on this humans been acquired by measuring blood endocannabinoids. Here we explored endocannabinoids related N-acylethanolamines saliva verified their changes relation body weight status response a meal or loss. Methodology/Principal Findings Fasting plasma salivary were...