A5085032287- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Diabetic Foot Ulcer Assessment and Management
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Wound Healing and Treatments
- Pancreatic and Hepatic Oncology Research
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Healthcare during COVID-19 Pandemic
- Lung Cancer Research Studies
- Diet and metabolism studies
- Meningioma and schwannoma management
- Bariatric Surgery and Outcomes
- Pain Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Parathyroid Disorders and Treatments
- Streptococcal Infections and Treatments
- Neurological and metabolic disorders
- Diabetes Treatment and Management
- Ophthalmology and Eye Disorders
- Peripheral Artery Disease Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Healthcare Regulation
Hospital de Santo António
2009-2025
Centro Hospitalar do Porto
2012-2024
Portuguese Air Force Academy
2024
Centro Hospitalar do Baixo Vouga
2022-2023
Weatherford College
2022
Diabetes Australia
2012
Fernando Pessoa University
2012
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
A drenagem ácida de mina (DAM) é um passivo ambiental associado à extração e beneficiamento do carvão mineral. lama proveniente tratamento DAM foi apontada como potencial fonte para elementos terras raras (ETR) pode significar uma nova receita a partir resíduo da mineração, ação alinhada aos objetivos transição energética justa. Nesse contexto, 20 locais contaminados com na região Bacia Carbonífera SC foram caracterizados quanto presença desses em relação suas características majoritárias....
Mutations in several genes have been associated with familial forms of pituitary adenomas. Sporadic adenomas (i.e. no family history or coexistent endocrine tumours) are also occasionally found to result from germline mutations these genes, especially young patients larger tumours. The aim this study was determine the frequency young-onset sporadic macroadenomas. A cohort 225 Portuguese macroadenomas diagnosed before age 40 years studied by whole exome sequencing (WES) followed analysis a...
Abstract The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with glucagon‐secreting alpha‐cell tumor of the pancreas. We present 67‐year‐old diabetic patient extensive cutaneous lesions, poor glycemic control. clinical investigation revealed pancreatic resolution systemic features after surgical removal. dermatologic endocrine approach to this discussed...
Mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene cause familial isolated pituitary adenomas (FIPA). AIP mutations have also been found patients with apparently sporadic adenomas, particularly young large adenomas. The aim of this study was to determine frequency germline young-onset macroadenomas.The sequenced 218 Portuguese macroadenomas diagnosed before age 40 years.Heterozygous rare sequence variants were identified 18 (8.3%) patients. However, only four (1.8%)...
To assess the accuracy of bilateral inferior petrosal sinus sampling both in differential diagnosis adrenocorticotrophic hormone dependent Cushing's syndrome and predicting localization on pituitary.The authors evaluated all patients that undergone a tertiary centre, between January 1995 March 2018. The probable disease was made when basal central/peripheral gradient was>2 and/or>3 after stimulation with corticotrophin releasing hormone. suggested inter-sinus was>1.4. results obtained were...
Introduction Immunotherapy has a crucial role in the current treatment of multiple malignancies. Albeit described as rare, new onset autoimmune diabetes is potentially life-threatening complication programmed cell death-1 (PD-1) inhibitors, such pembrolizumab, and its predisposing factors pathological mechanism are yet to be clarified. Case Report We present case 72-year-old man with high-grade bladder carcinoma undergoing pembrolizumab treatment. He had no personal or family history...
Background and aims Diabetic foot ulcer location is a known independent predictor for cure with better healing gradient proximal to distal. Although advanced age one of the main factors associated greater diabetic severity, there are no studies evaluating specifically in elderly population an outpatient setting. This study evaluated age-group interactions presentation. Methods A retrospective cohort including adult patients ulcers observed on their first visit our center's Foot Unit 2018,...
This study reports on the case of an elderly patient, with diabetes, and a bullous wound left big toe that led to amputation first second toes. The was because deep injury as it not able heal conventional treatment. After completing normal treatment removal bacterial infection in lesion, patient underwent based hydrogel gel (0.9% saline solution) hyperbaric oxygen therapy (HBOT). 60 sessions therapy, almost complete closure observed. There were no discomfort or during seven months healing...
The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been increasing in the last five decades, but there is no large-scale data regarding these tumours Portugal. We conducted a cross-sectional, multicentric study main Portuguese centers to evaluate clinical, pathological, and therapeutic profile GEP-NENs. From November, 2012, July, 2014, from 293 patients diagnosed with GEP-NENs 15 Portugal was collected registered an online electronic platform. Median age at...
The increase in life expectancy along with technological advances has translated into a higher number of pituitary adenomas (PA) diagnosed from the age 65. In elderly, symptoms related to comorbidities might overlap endocrine dysfunction, addition increasing anesthetic and surgical risks. This study aimed compare baseline clinical tumor features between patients PA different groups: younger adults (YA), 18 64 years, older (OA), ≥65 years. As secondary outcomes, we also intended assess:...
Summary Pituitary metastasis (PM) can be the initial presentation of an otherwise unknown malignancy. As PM has no clinical or radiological pathognomonic features, diagnosis is challenging. The authors describe case a symptomatic that revealed primary lung adenocarcinoma. A 62-year-old woman with multiple sclerosis and history malignancy, incidentally presented diffusely enlarged homogeneously enhancing pituitary gland associated stalk enlargement. Clinical biochemical evaluation anterior...
Foot ulceration and infection is associated with a substantial increase in morbidity mortality patients diabetes. We present clinical case of recurrent diabetic foot an atypical evolution. A 58-year-old male patient type 1 diabetes history bilateral Charcot neuroarthropathy was followed at our Diabetic Clinic for unhealed plantar ulcer >1.5 years episodes infection. He admitted to hospital due reinfection sepsis ipsilateral lower limb cellulitis. The found be underlying abscess the...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Objective Mutations in several genes have been associated with familial forms of pituitary adenomas. Sporadic adenomas (i.e. no family history or coexistent endocrine tumours) are also occasionally found to result from germline mutations these genes, especially young patients larger tumours. The aim this study was determine the frequency young-onset sporadic macroadenomas. Methods A cohort 225 Portuguese macroadenomas diagnosed before age 40 years studied by whole exome sequencing...
The capacity to speak in public requires personal skills that not everyone has. Anxiety and nervousness, many times easily classified as phobia, can represent serious handicaps committing the expected speaking performance. Being a subject rather explored by contemporaneous literature, this research wants contribute exploring Virtual Reality Gamification strategies for mitigating those difficulties. During project VR application Google Cardboards was developed, allow speakers immersively face...
What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)?
Cushing disease (CD), a rare endocrine disorder characterized by pituitary adenoma that secretes excess adrenocorticotropic hormone (ACTH), leads to overproduction of cortisol the adrenal glands and, depending on severity and duration, manifests with broad spectrum clinical signs symptoms, ranging from classical features more common conditions seen in general population. Discovery molecular pathogenic mechanisms related development CD tumors has increased recent years, almost two-thirds...