A5025832509- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Healthcare during COVID-19 Pandemic
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal Hormones and Disorders
- Neuroendocrine Tumor Research Advances
- HIV-related health complications and treatments
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Sexual Differentiation and Disorders
- Liver Disease Diagnosis and Treatment
- Youth, Drugs, and Violence
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Cardiovascular Disease and Adiposity
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2018-2025
Hospital de São João
2015-2024
Universidade Nova de Lisboa
2024
Universidade do Porto
2014-2023
Faculdade de Medicina do ABC
2015-2023
Diabetes Australia
2012-2023
Hospital Dr. Nélio Mendonça
2023
University of Tartu
2023
Universitat Autònoma de Barcelona
2023
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Survey (LAS) Database , relational database, designed to assess the profile of patients at diagnosis during long-term follow-up multiple treatment centers. following results were obtained diagnosis. study population consisted 3173 from ten countries; 54.5% female....
Intestinal fatty-acid binding protein (I-FABP) is expressed in epithelial cells of the mucosal layer small intestine tissue. When intestinal damage occurs, I-FABP released into circulation and its plasma concentration increases. In context obesity, gut barrier integrity can be disrupted by dietary fat while permeability increases.To investigate whether fatty acid a suitable marker injury inflammation obesity.Twelve male Wistar rats were randomly divided two groups six animals each: standard...
Over recent decades, epidemiological studies have been reporting worrisome trends in the incidence of human infertility rates. Extensive detection industrial chemicals serum, seminal plasma and follicular fluid has led scientific community to hypothesise that these compounds may disrupt hormonal homoeostasis, leading a vast array physiological impairments. Numerous synthetic natural substances endocrine-disruptive effects, acting through several mechanisms. The main route exposure is...
Abstract Context Cushing disease, a chronic hypercortisolism disorder, is associated with considerable morbidity and mortality. Normalizing cortisol production the primary treatment goal. Objective We aimed to evaluate safety efficacy of osilodrostat, potent, orally available 11βhydroxylase inhibitor, compared placebo in patients disease. Methods LINC 4 was phase III, multicenter trial comprising an initial 12-week, randomized, double-blind, placebo-controlled (osilodrostat:placebo, 2:1)...
To perform a post hoc analysis of the FIGHT trial, evaluating effect liraglutide (vs. placebo) on totality events in patients with heart failure reduced ejection fraction (HFrEF).FIGHT was double-blind randomized controlled trial (RCT) that studied versus placebo 300 recently hospitalized HFrEF followed for 180 days. The main outcome present total hospitalizations (HF) or all-cause death. Secondary outcomes included arrhythmic and prespecified interest (arrhythmias, sudden cardiac death,...
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
The association between selenium and inflammation the relevance of selenoproteins in follicular thyroid cell physiology have pointed to a putative role pathogenesis autoimmune diseases.The aim this study was evaluate promoter variation SEPS1, selenoprotein S gene, risk for developing Hashimoto's thyroiditis (HT).A case-control performed assess genetic SEPS1 gene (SEPS1 -105G/A single-nucleotide polymorphism, rs28665122) HT.The conducted north Portugal, Porto, period 2007-2013.A total 997...
Gut microbiota dysbiosis has been recognized as having key importance in obesity- and metabolic-related diseases. Although there is increasing evidence of the potential benefits induced by probiotics metabolic disturbances, a lack large cross-sectional studies to assess population-based prevalence probiotic intake Our aim was evaluate association ingestion with obesity, type 2 diabetes, hypertension, dyslipidemia. A study designed using data from National Health Nutrition Examination Survey...
<b><i>Introduction:</i></b> Bariatric surgery is an effective treatment for morbid obesity and its metabolic related comorbidities. However, the literature reports inconsistent results regarding weight loss (WL) resolution of comorbidities associated with obesity. <b><i>Objective:</i></b> We aim to evaluate long-term differences in WL between different surgical techniques impact each technique on parameters (type 2 diabetes mellitus [T2DM],...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (&lt;65...
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in development, progression, and severity. Our work aimed to explore summarize crosstalk between different organs, their hormones, dysfunctions. For instance, our results show hyperprolactinemia, hypercortisolemia, polycystic ovary syndrome seem worsen NAFLD’s pathway. Hypothyroidism low...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
Este artigo tem como objetivo realizar uma revisão da literatura científica sobre os avanços no tratamento osteoartrite, com ênfase nas intervenções cirúrgicas. Para isso, foram utilizados motores de busca indexadores PubMed, Scopus e Web of Science, a utilização dos unitermos "Osteoartrite, Tratamento cirúrgico, Avanços, Intervenções cirúrgicas". A revelou que, nos últimos anos, houve consideráveis inovações abordagens cirúrgicas para o aumento eficácia das técnicas minimamente invasivas,...
Este artigo tem como objetivo realizar uma revisão da literatura científica sobre os avanços no tratamento de politraumatizados, com ênfase nas intervenções cirúrgicas emergência. Para isso, foram utilizados motores busca indexadores PubMed, Scopus e Web of Science, a utilização dos unitermos "Politraumatizados, Tratamento cirúrgico emergência, Avanços, Manejo cirúrgico". A revelou que, nos últimos anos, houve significativos abordagens para o manejo implementação técnicas minimamente...