Alberto Giacinto Ambrogio
A5052841014- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Retinoids in leukemia and cellular processes
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Electrolyte and hormonal disorders
- Bioinformatics and Genomic Networks
- Stress Responses and Cortisol
- Ubiquitin and proteasome pathways
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
IRCCS Istituto Auxologico Italiano
2007-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2019
University of Milan
2007-2018
Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes. Our objective was evaluate the efficacy safety profile of in patients disease. This prospective, multicenter study. Seven disease (three men, four postmenopausal women) were started on 10 mg daily...
Summary Objective Cushing's syndrome (CS), when fully expressed, is easily diagnosed. Mild cases, however, may require careful distinction from pseudo‐Cushing's states as occur in depression, alcoholism, polycystic ovary disease and visceral obesity. The aim of the present study a reappraisal diagnostic accuracy two tests most commonly used to differentiate CS pseudo‐Cushing's: corticotropin‐releasing hormone (CRH) stimulation after low dose dexamethasone administration desmopressin...
The diagnosis of Cushing's syndrome requires highly sensitive screening tests. Therefore, diagnostic cutoffs have been lowered to maximize sensitivity and identify all patients. However, few studies investigated the impact these refinements on specificity first-line tests.The aim study was assessment three widely used tests in a large series suspects referred our endocrine service.We retrospectively reviewed results urinary free cortisol (UFC), 1-mg dexamethasone suppression test [overnight...
Evidence is limited regarding outcome of patients with ectopic Cushing's syndrome (ECS) due to neuroendocrine tumors (NETs).We assessed the prognostic factors affecting survival NETs and ECS.Retrospective analysis clinicopathological features, severity hormonal syndrome, treatments from a large cohort ECS collected 17 Italian centers.Our series included 110 patients, 58.2% female, mean (±s.d.) age at diagnosis 49.5 ± 15.9 years. The main sources ACTH were bronchial carcinoids (BC) (40.9%),...
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (<65...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Adrenocorticotrophic hormone (ACTH)‐secreting pituitary adenomas give rise to a severe endocrinological disorder, comprising Cushing's disease, with multifaceted clinical presentation and treatment outcomes. Experimental studies suggest that the disease variability is inherent tumour, thus indicating need for further into tumour biology. The present study evaluated transcriptome expression pattern in large series of ACTH‐secreting adenoma specimens order identify molecular signatures these...
<b><i>Background:</i></b> Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been shown to occur ACTH-secreting pituitary adenomas, thus calling attention ubiquitin system corticotrope adenomas. <b><i>Objectives:</i></b> Assess consequences of <i>USP8</i> and establish role on ACTH turnover human <b><i>Methods:</i></b> mutation status was established 126 Differences secretion...
We previously described in young thalassaemic patients an altered cortisol and ACTH responsiveness suggesting impaired adrenocortical reserve. Owing to iron overload, a worsening of adrenal function should be expected adult patients.In 124 adults with beta-thalassaemia, urinary free (UFC) plasma levels were determined compared those measured 150 controls. In 45 patients, was response to: i) tetracosactide 1 microg as i.v. bolus (low-dose test, LDT) ii) 250 infused over 8 h (high-dose...
Glucocorticoids stimulate several steps in red blood cell (RBC) development; however, little is known on changes erythroid parameters patients with Cushing's disease. The aim of this study was to assess both RBC and white (WBC) a large cohort disease report alterations the active phase after surgical remission.A total 80 (63 women 17 men) were studied before for up 254 months' follow-up (mean 65.8 ± 6.71 months) pituitary/adrenal surgery. Details counts reviewed compared data obtained from...
Recurrence of Cushing's disease after successful transsphenoidal surgery occurs in some 30% the patients and response to desmopressin shortly has been proposed as a marker for recurrence. The aim present study was evaluate over time surgery. We tested 56 with remission up 20 years ACTH cortisol evaluated on long-term or undergoing relapse; an increase by at least 27 pg/mL levels identified responders. vast majority who underwent adenomectomy failed respond this pattern maintained remission....
Desmopressin is a known haemostatic agent and also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, condition characterized by excess cortisol concentrations frequent thromboembolic events. No study has yet evaluated whether administration desmopressin for purposes induces significant, adverse changes in endothelial cell markers these patients.Administration to patients with disease comparable those observed obese normal weight subjects. It follows,...