A5042420012- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Meningioma and schwannoma management
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Myasthenia Gravis and Thymoma
- Thyroid Disorders and Treatments
- Ophthalmology and Eye Disorders
- Head and Neck Surgical Oncology
- Angiogenesis and VEGF in Cancer
- TGF-β signaling in diseases
- Stress Responses and Cortisol
- Retinoids in leukemia and cellular processes
- Genetic Syndromes and Imprinting
- Hormonal Regulation and Hypertension
- Neurofibromatosis and Schwannoma Cases
- Teratomas and Epidermoid Cysts
- Diet and metabolism studies
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
Vita-Salute San Raffaele University
2016-2025
IRCCS Ospedale San Raffaele
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
Universitätsklinikum Würzburg
2025
University of Würzburg
2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2001-2024
San Raffaele University of Rome
2007-2022
University of Padua
2018
Università della Svizzera italiana
2018
Institute of Oncology Research
2018
Abstract Objective The aim of the Acromegaly Consensus Group was to revise and update consensus on diagnosis treatment acromegaly comorbidities last published in 2013. Participants Group, convened by 11 Steering Committee members, consisted 45 experts medical surgical management acromegaly. authors received no corporate funding or remuneration. Evidence This evidence-based developed using Grading Recommendations, Assessment, Development, Evaluation (GRADE) system describe both strength...
Craniopharyngioma accounts for 2%-5% of all primary intracranial neoplasms. The optimal management craniopharyngioma remains controversial. authors evaluated the early results surgery and longterm risk tumor recurrence in a large series patients undergoing resection craniopharyngiomas.Between 1990 2008, 112 consecutive (57 male 55 female with mean [± SEM] age 33.3 ± 1.8 years) underwent craniopharyngiomas at authors' hospital. Recurrence or growth residual tissue during follow-up was...
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
Abstract Purpose The 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy. Methods Fifty-six experts from 16 countries reviewed discussed current evidence focused on assays; the role imaging, pathology, clinical assessments; consequences diagnostic delay; remission recommendations follow up; value assessment monitoring in defining disease progression, selecting appropriate treatments, maximizing...
The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history these rare tumors. aim this study was evaluate clinical data at presentation post-surgery radiotherapy in a cohort with NFPA.A computerized database developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration 295 NFPA performed seven Endocrinological Centers North West Italy. Data were...
To report the efficacy and safety of microsurgical transsphenoidal surgery in a series previously untreated patients with pituitary adenoma.One thousand one hundred forty consecutive undergoing resection adenoma at our department from January 1990 through December 2002 were included study. Postoperative results classified uniformly during period Patients considered remission disease when strict hormonal radiological criteria cure met.The most frequent tumor type was clinically nonfunctioning...
Nonfunctioning pituitary adenomas (NFPAs) are benign tumors of the gland that typically cause visual and/or hormonal dysfunction. Surgery is treatment choice, but patients remain at risk for tumor recurrence several years afterwards. The authors evaluate early results surgery and long-term in with NFPAs.Between 1990 2005, 491 previously untreated NFPA underwent Università Vita-Salute. Determinations or growth residual tissue during follow-up period were based on neuroradiological...
Objective To describe demographic and hormonal characteristics, comorbidities (diabetes mellitus hypertension), therapeutic procedures their effectiveness, as well predictors of morbidity mortality in a nationwide survey Italian acromegalic patients. Design Retrospective multicenter epidemiological study endorsed by the Society Endocrinology performed 24 tertiary referral centers. The mean follow-up time was 120 months. Results A total 1512 patients, 41% male, age: 45±13 years, GH: 31±37...
Giant pituitary adenomas, defined as those measuring at least 4 cm in maximum diameter, are a therapeutic challenge. We report our experience large, consecutive series of patients with giant adenomas.Between 1990 and 2004, 95 adenomas underwent surgery department. Nonfunctioning adenoma was the most frequent type (n = 70; 73.7%), whereas hormone-secreting numbered only 25 (26.3%). The mean age time (+/-standard error mean) 48.4 +/- 1.5 years; there were 66 men (69.5%) 29 women (20.5%).In...
Transsphenoidal surgery (TSS) is the treatment of choice for Cushing's disease (CD). Postoperative hypercortisolemia mandates further therapy.The aim study was to characterize patients without immediate postoperative remission who have a delayed decrease normal or low cortisol levels therapy.A retrospective case series conducted at three tertiary care centers.We reviewed records 620 (512 females, 108 males; mean age, 38 +/- 13 yr) underwent transsphenoidal pituitary CD between 1982 and...
To describe clinical and pathological characteristics treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).Electronic survey August 2020-May 2021.96% 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven considered clinically benign, demonstrated behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% men. Adrenocorticotrophic hormone (ACTH)-secreting constituted 30% APT/PC,...
Prolactinomas are the most frequent pituitary adenomas. Prolactinoma may occur in different clinical settings and always require an individually tailored approach. This is reason why a panel of Italian neuroendocrine experts was charged with task to provide indications for diagnostic therapeutic approaches that can be easily applied contexts. The document provides 15 recommendations diagnosis 54 treatment, issued according GRADE system. level agreement among members formally evaluated by...
Cushing syndrome is caused by an excess of adrenocorticotropic hormone (ACTH) production neuroendocrine tumors, which subsequently results in chronic glucocorticoid excess. We found that retinoic acid inhibits the transcriptional activity AP-1 and orphan receptors Nur77 Nurr1 ACTH-secreting tumor cells. Retinoic treatment resulted reduced pro-opiomelanocortin transcription ACTH production. inhibition was also observed human pituitary cells a small-cell lung cancer cell line, but not normal...
Medical therapy with dopaminergic drugs is the preferred initial treatment for symptomatic prolactin (PRL)-secreting adenomas; but in recent years, there has been a renewed interest surgery. The aim of this study to report large series patients operated prolactinoma last 10 yr. A total 120 consecutive (93 female, 27 male) underwent surgery from January 1990 December 1999. Their mean age at was 29.7 +/- 0.9 Fifty-nine (49.2%) had microadenoma, and remaining 61 (50.8%) macroadenoma, which 24...
Radiation therapy diminishes the risk of recurrence incompletely removed nonfunctioning pituitary adenoma (NPA). The authors evaluated efficacy and safety gamma knife surgery (GKS) in patients with residual NPA following surgical debulking tumor.Fifty-four patients, 26 men 28 women, ranging age from 29 to 72 years underwent treatment. Baseline follow-up studies involved magnetic resonance imaging, hormone evaluation, neuroophthalmological examination 6 12 months after GKS at yearly intervals...
Single-session stereotactic radiotherapy (SR) may be a potential adjuvant treatment in acromegaly.We analyzed the safety and efficacy of SR patients who had previously received maximal surgical debulking at our center.The study was retrospective analysis hormonal, radiological, ophthalmologic data collected predefined protocol from 1994 through 2006.The performed university hospital.Eighty-three acromegalic patients, 52 women 31 men, with mean age 42.6 +/- 1.2 yr, participated study. The...
Objective The prognosis of either pituitary carcinoma or aggressive adenoma resistant to standard therapies is poor. We assessed the efficacy treatment with temozolomide, an oral second-generation alkylating agent, in a consecutive series six patients adenomas. Design This was 1-year prospective study temozolomide therapy (one case) atypical (five cases) therapies. There were three males and females. Age at enrollment ranged between 52 64 years. Temozolomide given orally dose 150–200 mg/m 2...