A5037861191- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Myasthenia Gravis and Thymoma
- Receptor Mechanisms and Signaling
- Meningioma and schwannoma management
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- Research on Leishmaniasis Studies
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Nephrotoxicity and Medicinal Plants
- RNA modifications and cancer
- Cardiac tumors and thrombi
- Neuropeptides and Animal Physiology
Universidade Estadual de Londrina
2012-2022
University of Padua
2018
Universidade de São Paulo
2014
Centre Hospitalier de l’Université de Montréal
2009-2012
Université de Montréal
2009-2010
Centre Hospitalier Universitaire de Grenoble
2004-2009
Universidade Federal de Santa Catarina
1999-2009
Laboratoire de Génétique Cellulaire
2007
Inserm
2004-2006
Université Grenoble Alpes
2004-2006
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
OBJECTIVE:Phaeochromocytoma is a rare tumour of the chromaffin cells, diagnosis which based on an assay metanephrines and treatment surgical excision tumour. It usually discovered due to rich varied symptomatology or classic paroxysmal hypertension. The main purpose this study was specify exact circumstances discovery phaeochromocytomas operated in our university hospital between 1990 2002. DESIGN AND METHODS: Forty-one consecutive complete case reports patients who had surgery for...
Background and purpose: α‐Humulene trans ‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical systemic anti‐inflammatory effects different experimental models. However, molecular mechanisms through they exert their activity still remain unclear. Here, we evaluate α‐humulene on acute inflammatory responses elicited by LPS. Experimental approach: The biological activities were investigated a model inflammation rat paw, induced...
Adrenal vein sampling (AVS) is required to identify a lateralized or bilateral aldosterone source in primary aldosteronism.Our objectives were compare basal and post-ACTH selectivity ratio (SR) lateralization (LR) determine the prevalence of contralateral suppression its effect on surgical outcome.Bilateral simultaneous adrenal samples obtained before after 250-μg bolus ACTH. Analyses conducted 171 technically successful AVS subgroup 66 operated patients with evaluable outcome data.ACTH...
Acute kidney injury (AKI) represents a complex clinical condition associated with significant morbidity and mortality. Approximately, 19-33% AKI episodes in hospitalized patients are related to drug-induced nephrotoxicity. Although, considered safe, non-steroidal anti-inflammatory drugs such as diclofenac have received special attention the past years due potential risk of renal damage. Vinpocetine is nootropic drug known properties. In this study, we investigated effect mechanisms...
To describe clinical and pathological characteristics treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).Electronic survey August 2020-May 2021.96% 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven considered clinically benign, demonstrated behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% men. Adrenocorticotrophic hormone (ACTH)-secreting constituted 30% APT/PC,...
A recent microarray study identified a set of genes whose combined expression patterns were predictive poor outcome in cohort adult adrenocortical tumors (ACTs). The difference between the values measured by qRT-PCR DLGAP5 and PINK1 was best molecular predictor recurrence malignancy. Among carcinomas, BUB1B most reliable overall survival. prognostic heterogeneity ACTs raises need to applicability these markers other cohorts.To validate BUB1B, DLGAP5, as from Brazilian pediatric...
alpha- and beta-amyrin are pentacyclic triterpenes found in plants known to exhibit pronounced anti-inflammatory effects. Here, we evaluated the effects of a 1:1 mixture (alpha,beta-amyrin) on an experimental model colitis mice.Colitis was induced Swiss male mice by trinitrobenzene sulphonic acid (TNBS) followed up 72 h; animals were treated systemically with alpha,beta-amyrin, dexamethasone or vehicle. Macro- microscopic damage, myeloperoxidase activity cytokine levels assessed colons....
Leukotrienes are important mediators of inflammatory responses. In this study, we investigated the effect absence 5-lipoxygenase (5-LO)-derived leukotrienes on levels cytokines, nitric oxide (NO) and iNOS expression in cardiac tissue mice infected with Trypanosoma cruzi, agent Chagas' disease. NO is a key mediator parasite killing experimentally T. previous studies have suggested that leukotrienes, such as LTB(4), induces synthesis cruzi-infected macrophages plays relevant role NO-dependent...
Abstract Context Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response first-generation somatostatin receptor ligands (fg-SRLs) the treatment acromegaly. Objective To develop a prediction model therapeutic acromegaly fg-SRL. Methods Patients with not cured by primary surgical and who had adjuvant therapy fg-SRL for at least 6 months after surgery were included. considered controlled if they presented growth hormone (GH)...
Context: Aberrant expression of LH/human chorionic gonadotropin (hCG) receptor has been suggested in several cases bilateral macronodular adrenal hyperplasia with Cushing's syndrome. The cortisol production is then directly controlled by endogenous secretion LH/hCG. However, the direct involvement this aberrant LH/hCG development not demonstrated. Moreover most cases, whenever investigated, associated ectopic other G protein-coupled receptors such as gastric inhibitory polypeptide,...
Abstract Background: Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes have not yet been identified tumors. Objective: Our objective was to identify deregulated tumors harboring CTNNB1 genetic alterations nuclear accumulation β-catenin. Methods: Microarray analysis a dataset that were differently expressed between AA with mutations wild-type (WT) Within this dataset, expression profiles five validated by real...
Aberrant expression of ectopic G protein-coupled receptors (GPCRs) in adrenal cortex tissue has been observed several cases ACTH-independent macronodular hyperplasias and adenomas associated with Cushing's syndrome. Although there is clear clinical evidence for the implication these abnormal regulation cortisol production, whether this aberrant GPCR cause or consequence development an hyperplasia still open question. To answer it, we genetically engineered primary bovine adrenocortical cells...
the purpose of present work was to investigate effect cyclooxygenase-2 (COX-2) inhibition on cardiovascular and inflammatory aspects promoted by monosodium glutamate (MSG)-induced obesity in rats.Neonatal Wistar male rats were injected with MSG (4 mg/g body weight ID) or equimolar saline (control). Treatment celecoxib (50 mg/kg ip) (0.9% NaCl began at 60 days age. At 90 days, all anesthetized for catheterization femoral artery, mean arterial pressure (MAP) heart rate (HR) recorded once...
Multidrug resistance (MDR) constitutes the major obstacle to successful treatment of cancer. In several cancer cells, MDR is thought be mediated by super-expression P-glycoprotein (Pgp). Pgp extrudes drugs from therefore reducing their cytotoxicity, and its activity inhibition may reverse phenotype. The present study evaluated possible cytotoxic effect reversing properties extract compounds isolated Phyllanthus amarus. To this purpose, two human leukaemia cell lines were employed: K-562...
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and effective anti-inflammatories despite the well-known side effects such as gastrointestinal damage, acute kidney injury (AKI), cardiovascular dysfunctions. Diclofenac is among most prescribed NSAIDs due to its efficient analgesic properties. Patients using diclofenac possess 77% risk increase develop AKI. Activation of NF-κB contributes diclofenac-induced AKI, which in line with use glucocorticoids one management choices treat...
Bilateral adrenalectomy is the standard treatment for Cushing's syndrome (CS) related to ACTH-independent bilateral macronodular hyperplasia (AIMAH), although it imposes life-long adrenal insufficiency. This study reports a clinical case in order discuss interest of pharmacological β-blockade illegitimate membrane receptors and unilateral as alternatives CS due AIMAH. Evidence cortisol stimulation by upright posture insulin-induced hypoglycemia patient with AIMAH led us try β-blockers...
Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) can be associated with abnormal responses of aberrantly expressed adrenocortical receptors. This study aimed characterize in vitro the pathophysiology hypercortisolism a b-blocker-sensitive AIMAH. Cortisol secretion profile under aberrant receptors stimulation revealed hyperresponsiveness salbutamol (beta2-adrenoceptor agonist), cisapride (5-HT4 receptor and vasopressin AIMAH cultured cells, but not normal...