A5078419955- Neuroinflammation and Neurodegeneration Mechanisms
- Adrenal and Paraganglionic Tumors
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Immune Response and Inflammation
- Cardiac tumors and thrombi
- Parkinson's Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Ubiquitin and proteasome pathways
- Neuroscience and Neural Engineering
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Neurological disorders and treatments
- TGF-β signaling in diseases
- Autism Spectrum Disorder Research
- interferon and immune responses
- Sarcoma Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Immune responses and vaccinations
- Cancer-related cognitive impairment studies
- Protein Degradation and Inhibitors
Université Laval
2010-2018
Centre hospitalier universitaire de Québec
2013
Centre Hospitalier de l’Université de Montréal
2006-2011
Université de Montréal
2007-2010
An imbalance between remyelinating and demyelinating rates underlies degenerative processes in diseases such as multiple sclerosis. optimal therapeutic strategy would be to stimulate remyelination while limiting demyelination. Although accumulation of myelin debris impairs remyelination, the mechanisms regulating clearance by mononuclear phagocytic cells are poorly understood. We demonstrate that after cuprizone intoxication, CCR2-dependent infiltration mouse bone marrow–derived is abundant...
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The pathogenesis this neurodegenerative disease, currently without curative treatment, associated with accumulation amyloid β (Aβ) in brain parenchyma and cerebral vasculature. AD patients are unable to clear toxic peptide, leading Aβ their brains and, presumably, pathology devastating disease. Compounds that stimulate immune system may therefore have great therapeutic potential patients. Monophosphoryl lipid A (MPL) an...
Summary Objective Molecular alterations remain largely unknown in most sporadic adrenocortical tumours and hyperplasias. In our previous work, we demonstrated the differential expression of several Wnt/β‐catenin signalling‐related genes implicated ACTH‐independent macronodular adrenal hyperplasias (AIMAH). To better understand role signalling tumours, performed mutational analysis β‐catenin gene. Methods We studied 53 human samples (33 adenomas, 4 carcinomas, 13 AIMAH, 3 ACTH‐dependent...
Primary pigmented nodular adrenocortical disease (PPNAD) leads to Cushing syndrome (CS) and is often associated with Carney complex (CNC). Genetic alterations of the type 1-alpha regulatory subunit cAMP-dependent protein kinase A (PRKAR1A) phosphodiesterase 11A4 (PDE11A) genes have been found in PPNAD. Recent studies demonstrated that beta-catenin mutations are frequent adenomas carcinomas Wnt-signalling pathway involved PPNAD tumorigenesis. We hypothesized form context may harbour mutations.
Microglia are the brain-resident macrophages tasked with defense and maintenance of central nervous system (CNS). The hematopoietic origin microglia has warranted a therapeutic potential for in treating diseases CNS. However, migration bone marrow-derived cells (BMDC) into CNS is marginal event under normal, healthy conditions. A busulfan-based chemotherapy regimen was used marrow transplantation wild-type mice before subjecting them to hypoxic-ischemic brain injury or APP/PS1 prior...
Understanding how bone marrow-derived cells (BMDCs) enter the central nervous system (CNS) is critical for development of therapies brain-related disorders using hematopoietic stem cells. We investigated brain damages and blood-brain barrier (BBB) modification following either whole-body irradiation or a myeloablative chemotherapy regimen in mice, capacity these treatments to induce entry BMDCs into CNS. Neither treatment had lasting effect on integrity both were equally efficient at...
Abstract Background: Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes have not yet been identified tumors. Objective: Our objective was to identify deregulated tumors harboring CTNNB1 genetic alterations nuclear accumulation β-catenin. Methods: Microarray analysis a dataset that were differently expressed between AA with mutations wild-type (WT) Within this dataset, expression profiles five validated by real...
Parkinson's disease is a progressive neurodegenerative condition with considerable health and economic burden1. It characterized by the loss of midbrain dopaminergic neurons diminished response to symptomatic medical or surgical therapy as progresses2. Cell aims replenish lost their striatal projections intrastriatal grafting. Here, we report results an open-label phase I clinical trial (NCT04802733) investigational cryopreserved, off-the-shelf neuron progenitor cell product (bemdaneprocel)...
Abstract Context: The mechanisms responsible for the ectopic adrenal expression of glucose-dependent insulinotropic peptide (GIP) receptor (GIPR) in GIP-dependent Cushing’s syndrome (CS) are unknown. Chronic stimulation by ACTH disease or GIP ACTH-independent macronodular hyperplasia both lead to induction genes implicated proliferation and steroidogenesis. Objective: objective study was identify differentially expressed specifically CS that could be GIPR. Methods: We used Affymetrix U133...
Primary adrenal Cushing's syndrome can result from the aberrant expression of several hormone receptors; this mechanism has not been explored in detail aldosterone-producing tumors.The objective study was to evaluate a 56-yr-old male patient with an aldosteronoma for regulation aldosterone secretion by receptors.Renin-independent stimulation observed vivo after mixed meal, oral glucose, or administration glucose-dependent insulinotropic peptide (GIP), vasopressin, and tegaserod. The...
Abstract Microglia are the brain‐resident macrophages tasked with defense and maintenance of central nervous system (CNS). The hematopoietic origin microglia has warranted a therapeutic potential for in treating diseases CNS. However, migration bone marrow‐derived cells (BMDC) into CNS is marginal event under normal, healthy conditions. A busulfan‐based chemotherapy regimen was used marrow transplantation wild‐type mice before subjecting them to hypoxic–ischemic brain injury or APP/PS1 prior...
INTRODUCTION: None of the available therapies for PD directly address loss dopaminergic neurons. Bemdaneprocel is an investigational cellular therapy composed midbrain neuronal cells derived from human embryonic stem cells. METHODS: In this open-label study 12 subjects have received 1 2 doses bemdaneprocel to putamen bilaterally, along with a 1-year immunosuppression regimen. Safety and tolerability been assessed, assessments engraftment clinical impact. RESULTS: At screening, average age...
Abstract Bone marrow transplantation is the standard of care for a host diseases such as leukemia and multiple myeloma, well genetically inherited metabolic affecting central nervous system. In mouse models, bone has proven valuable tool understanding hematopoietic system homing cells to their target organs. Many techniques have been developed create chimeric mice, animals with derived from genetic background that differs rest body. Current tools allow virtually limitless possibilities in...
Explore the impact of bemdaneprocel on non-motor symptoms in participants with Parkinson's disease.
This first-in-human phase 1 study assesses the safety, tolerability, and clinical outcomes of bemdaneprocel in participants with Parkinson's disease.
Evaluate [18F]-fluorodopa (18F-DOPA) positron emission tomography (PET) signal 18 months post transplantation (6 after cessation of immunosuppression) in 12 participants who received intraputamenal transplants bemdaneprocel.