A5027140673- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Nerve injury and regeneration
- Inflammatory mediators and NSAID effects
- Hormonal Regulation and Hypertension
- Circadian rhythm and melatonin
- interferon and immune responses
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Herpesvirus Infections and Treatments
- Cholinesterase and Neurodegenerative Diseases
Université Laval
2015-2024
Wilfrid Laurier University
2008-2024
Centre hospitalier universitaire de Québec
2005-2023
Quebec Research and Development Centre
2016-2022
Centre hospitalier de l'Université Laval
2004-2020
Universidade de São Paulo
2003-2009
Endocrinology Research Center
1999-2008
Salk Institute for Biological Studies
1991-2007
Laboratory of Molecular Genetics
2005
The University of Texas at Austin
2003
The recent cloning of a second estrogen receptor (ER) provided new tool to investigate and clarify how estrogens are capable communicating with the brain influence gene expression neural function. purpose present study was define neuroanatomical organization each subtype using side-by-side approach characterize cellular population(s) expressing ERβ transcript in endocrine hypothalamus immunohistochemistry combined situ hybridization. Axonal transport inhibition accomplished cause...
An imbalance between remyelinating and demyelinating rates underlies degenerative processes in diseases such as multiple sclerosis. optimal therapeutic strategy would be to stimulate remyelination while limiting demyelination. Although accumulation of myelin debris impairs remyelination, the mechanisms regulating clearance by mononuclear phagocytic cells are poorly understood. We demonstrate that after cuprizone intoxication, CCR2-dependent infiltration mouse bone marrow–derived is abundant...
The recent characterization of human homologues Toll may be the missing link for transduction events leading to NF-kappaB activity and proinflammatory gene transcription during innate immune response. Indeed, CD14 is not thought participate directly in cell signaling, but rather one or more mammalian Toll-like receptors (TLRs) acts concert with lipopolysaccharide (LPS) receptor discriminate between microbial pathogens their products initiate transmembrane signaling. Mammalian cells express...
Innate responses in the CNS are critical to first line defense against infection and injury. Leukocytes migrate inflammatory sites response chemokines. We studied leukocyte migration glial chemokine expression within denervated hippocampus axonal injury caused by entorhinodentate lesions. A population of Mac1/CD11b+ CD45high macrophages (distinct from CD45low microglia) was specifically detected lesion-reactive 12 hr after Significant infiltration CD3+ T cells did not occur until 24 axotomy....
Corticotropin-releasing factor (CRF) is released in response to various stressors and regulates adrenocorticotropin secretion glucocorticoid production. In addition its endocrine functions, CRF acts as a neuromodulator extra-hypothalamic systems has been shown play role behavioral responses stress. overproduction implicated affective disorders such depression anorexia nervosa. A transgenic mouse model of developed order examine the effects chronic excess. animals exhibit abnormalities...
Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well understood and difficult treat. Although CNS hyperexcitability a critical component, recent findings challenge the neuron-centric view neuropathic etiology pathology. Indeed, glial cells were shown play an active role in initiation maintenance hypersensitivity. However, origins these triggers that induce their activation have yet be elucidated. Here we show that, after nerve injury induced by partial...
IL-1β and TNF are potential targets in the management of neuropathic pain after injury. However, importance IL-1 systems for peripheral nerve regeneration mechanisms by which these cytokines mediate effects to be fully elucidated. Here, we demonstrate that mRNA protein levels rapidly upregulated injured mouse sciatic nerve. Mice lacking both TNF, or type 1 receptor (IL-1R1) (TNFR1), showed reduced nociceptive sensitivity (mechanical allodynia) compared with wild-type littermates...
MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of specific binding sites located mainly in their 3'-untranslated region (UTR). Loss miRNA control gene expression is thus expected underlie serious genetic diseases. Intriguingly, previous post-mortem analyses showed higher beta-amyloid precursor protein-converting enzyme (BACE) protein, but not mRNA, levels the brain patients that suffered from Alzheimer disease (AD). Here we also observed a...
Microglia are the immune cells of brain, they activated in brain Alzheimer's disease (AD) patients and mouse models AD, express innate receptor toll-like 2 (TLR2). The present study investigated role this progression AD-like pathologies. Here we show that amyloid β (Aβ) stimulates TLR2 expression a small proportion microglia. We then generated triple transgenic mice deficient from harbor mutant human presenelin 1 chimeric mouse/human precursor protein (APP) genes. deficiency accelerated...
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The pathogenesis this neurodegenerative disease, currently without curative treatment, associated with accumulation amyloid β (Aβ) in brain parenchyma and cerebral vasculature. AD patients are unable to clear toxic peptide, leading Aβ their brains and, presumably, pathology devastating disease. Compounds that stimulate immune system may therefore have great therapeutic potential patients. Monophosphoryl lipid A (MPL) an...
Abstract Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS). Chondroitin sulfate proteoglycans (CSPGs) have been reported accumulate MS lesions, and we thus examined the functional roles CSPGs on oligodendrocyte precursor cells (OPCs), oligodendrocytes, remyelination. Methods: We evaluated expression lysolecithin‐injected mouse spinal cord, an animal model demyelination spontaneous The impact OPCs was investigated using cultured adult murine...
Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta (Aβ) that assumed to result from impaired elimination this neurotoxic peptide. Most patients with AD also exhibit cerebral angiopathy, which consists Aβ deposition within vasculature. The contribution monocytes in has so far been limited macrophage precursors. In study, we aimed investigate whether circulating could play a role Aβ. With live intravital two-photon microscopy, demonstrate patrolling are attracted and...
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder affecting older people worldwide. It a progressive mainly characterized by presence of amyloid-beta (Aβ) plaques and neurofibrillary tangles within brain parenchyma. now well accepted that neuroinflammation constitutes an important feature in AD, wherein exact role innate immunity remains unclear. Although immune cells are at forefront to protect toxic molecules including Aβ, this natural defense mechanism seems...
Pluripotent stem cells can differentiate into a variety of cell types during tissue development and regeneration. However, it is still unclear whether bone marrow-derived migrate across the blood-brain barrier in many regions central nervous system (CNS) if these readily functional parenchymal microglia. We thus studied differentiation fate marrow upon immigration CNS. To this end, we systemically transplanted that express green fluorescent protein (GFP) lethally irradiated mice found...