A5023895372- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Single-cell and spatial transcriptomics
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Salivary Gland Tumors Diagnosis and Treatment
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Radiopharmaceutical Chemistry and Applications
- Fetal and Pediatric Neurological Disorders
- Cell Image Analysis Techniques
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
Memorial Sloan Kettering Cancer Center
2020-2025
Neurological Surgery
2016-2024
NYU Langone Health
2024
Kettering University
2023-2024
Cornell University
2023
St. Michael's Hospital
2021
University of Manchester
2016-2019
Salford Royal Hospital
2018-2019
Salford Royal NHS Foundation Trust
2017-2019
Manchester Academic Health Science Centre
2017-2018
Abstract Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), yet the study BM genomics has been limited by tissue access, incomplete clinical data, and a lack comparison paired extracranial specimens. Here we report cohort 233 resected sequenced (MSK-IMPACT) NSCLC comprehensive data. With matched samples (47 primary tumor, 42 metastatic), show CDKN2A/B deletions cycle pathway alterations be enriched in samples. Meaningful clinico-genomic correlations...
Summary Malignant gliomas follow two distinct natural histories: de novo high grade tumors such as glioblastoma, or lower with a propensity to transform into disease. Despite differences in tumor genotype, both entities converge on common histologically aggressive phenotype, and the basis for this progression is unknown. Glioma associated macrophages (GAM) have been implicated process, however GAMs are ontologically transcriptionally diverse, rendering isolation of pathogenic subpopulations...
Abstract Both subthalamic nucleus (STN) and caudal zona incerta (cZI) have been implicated as the optimal locus for deep brain stimulation (DBS) in Parkinson’s disease (PD). We present a retrospective clinico-anatomical analysis of outcomes from DBS targeting both STN cZI. Forty patients underwent bilateral using an image-verified implantable guide tube/stylette technique. Contacts on same quadripolar lead were placed After pulse generator programming, contacts yielding best clinical effect...
In the United Kingdom, ultrasound-guided external ventricular drain (EVD) insertion is becoming standard of care to mitigate morbidity associated with catheter malposition and multiple passes. Many neurosurgeons routinely use ultrasound check preinsertion trajectory, although real-time visualization cannulation preferable since minor deviations can be significant in patients smaller ventricles, live further enables tip adjusted away from choroid plexus. Such navigation has traditionally been...
INTRODUCTION: None of the available therapies for PD directly address loss dopaminergic neurons. Bemdaneprocel is an investigational cellular therapy composed midbrain neuronal cells derived from human embryonic stem cells. METHODS: In this open-label study 12 subjects have received 1 2 doses bemdaneprocel to putamen bilaterally, along with a 1-year immunosuppression regimen. Safety and tolerability been assessed, assessments engraftment clinical impact. RESULTS: At screening, average age...
Chylomicron remnants bound to rabbit alveolar macrophages with high-affinity (Kd = 3.3 ± 0.71 μg of protein/mL). The binding chylomicron was competitively inhibited in the presence unlabeled and a lesser extent by low-density lipoproteins. Pretreatment cells either trypsin or pronase degradation dose time dependent manner, suggesting involvement cell surface protein. were degraded from Watanabe heritable hyperlipidemic (WHHL) rabbits, which are devoid LDL receptor activity. Moreover,...
Aims Resident and peripherally derived glioma associated microglia/macrophages ( GAMM ) play a key role in driving tumour progression, angiogenesis, invasion attenuating host immune responses. Differentiating these cells’ origins is challenging current preclinical models such as irradiation‐based adoptive transfer, parabiosis transgenic mice have limitations. We aimed to develop novel nonmyeloablative transplantation NMT mouse model that permits high levels of peripheral chimerism without...
Background Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment well established, however disease invariably recurs and improving prognosis challenging. With aim of personalizing therapy at recurrence, we have established a high content screening (HCS) platform to analyze sensitivity profile seven patient-derived cancer stem cell lines 83 FDA-approved chemotherapy drugs, with without irradiation. Methods Seven were...
In patients with pituitary adenomas, intra-cranial aneurysms can be an incidental finding, and are usually located outside the region. The authors describe multi-modal management of a rare case aneurysm supraclinoid carotid that encroached into macroadenoma.