A5090059495- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Vascular Malformations Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Ocular Oncology and Treatments
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Anatomy and Medical Technology
- Cell Image Analysis Techniques
- Spinal Dysraphism and Malformations
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- History of Medical Practice
- Innovations in Medical Education
Royal Manchester Children's Hospital
2016-2025
Brain Tumour Research
2015-2025
Manchester University NHS Foundation Trust
2024-2025
Northern Health and Social Care Trust
2025
University of Manchester
2000-2024
Manchester Academic Health Science Centre
2015-2023
The Christie NHS Foundation Trust
2023
Salford Royal Hospital
2006-2019
Boston Children's Hospital
2009-2015
University of Salford
2013-2014
This study describes a method for imaging brain tumors that combines T1-weighted (T1W) and T2*-weighted (T2*W) dynamic contrast-enhanced acquisitions. Several technical improvements have been made to produce high-quality three-dimensional mapping of endothelial permeability surface area product (k) leakage space (vl), based on T1W data. Tumor blood volume maps are obtained from T2*W images with complete removal residual relaxivity effects. The was employed in 15 patients (5 gliomas, 5...
Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years rare children young adults. Multiple and/or meningiomas more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary do not. Nevertheless, apparently sporadic patients may herald syndrome.To determine the frequency of known heritable meningioma- or schwannoma-predisposing mutations presenting meningioma schwannoma.Using database...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Choroid plexus carcinomas (CPCs) are rare pediatric tumors with a generally poor prognosis. Although the role of surgery is well recognized, adjuvant chemotherapy and radiation therapy remains unclear. In this paper, authors' goal was to assess second-look neoadjuvant ifosfamide, carboplatin, etoposide (ICE) in management CPC study neurocognitive outcome.The authors performed an institutional retrospective review patients whom diagnosed between 1985 2006 at Hospital for Sick Children...
Dynamic susceptibility contrast-enhanced magnetic resonance (MR) imaging in tumors is restricted by relaxivity effects, which may obscure any abnormality of first-pass kinetics the re-circulation phase. The purposes this study were a) to document magnitude effects with a variety commonly used MR techniques; and b) determine whether phase curve differs from that normal tissue. We have confirmed residual can be eliminated dynamic data several techniques. Application these methods enhancing...
<h3>Background</h3> Neurofibromatosis Type 2 (NF2) is a dominantly inherited tumour syndrome with phenotype which includes bilateral vestibular (eighth cranial nerve) schwannomas. Conventional thinking suggests that these tumours originate at single point along the superior division of eighth nerve. <h3>Methods</h3> High resolution MRI was performed in children genetically proven to have NF2. The nerve (SVN) and inferior (IVN) were visualised their course points origin calculated as...
OBJECT Choroid plexus carcinomas (CPCs) are rare brain tumors originating from the ventricular choroid plexus. They account for 2%-4% of all pediatric and most frequently seen in very young children. This proclivity, combination with a marked vascularity, renders an aggressive resection difficult often dangerous endeavor. Blood losses several total blood volumes small children not uncommon, sometimes forcing neurosurgeon to abort procedure, leaving residual tumor. Great extent tumor is...
Surgeries for CNS tumors are frequently performed by general neurosurgeons and those who specialize in surgical neurooncology. Subspecialization neurosurgical practice has become common may improve patient morbidity mortality rates. However, the potential benefits patients of having their surgeries neurooncologists remain unclear. Recently, a shift care to predominantly neurooncology been promoted. Evidence this is lacking therefore requires fundamental investigation.The authors conducted...
Craniopharyngiomas are one of the most frequently diagnosed hypothalamo-pituitary tumors in childhood. The adamantinomatous histological subtype accounts for pediatric cases, while papillary variant is almost exclusively adults. Here, we report a case craniopharyngioma very young child, confirmed by molecular tissue analysis. A 4-year-old girl was being investigated symptomatic central hypothyroidism. Brain MR imaging revealed large solid/cystic suprasellar mass, splaying optic chiasm and...
Intracranial pressure (ICP) measurement is an important diagnostic tool in Neurosurgery. Until relatively recently, conventional monitoring has required that subjects be admitted to a hospital bed and the device only able left in-situ for limited periods of time. We have evaluated Telemetric ICP system been proven, by several other groups worldwide, permit rapid, repeated prolonged measurement, multiple environments. In our unit, 4 patients implanted to-date, between ages 16, manifesting...
Aims Resident and peripherally derived glioma associated microglia/macrophages ( GAMM ) play a key role in driving tumour progression, angiogenesis, invasion attenuating host immune responses. Differentiating these cells’ origins is challenging current preclinical models such as irradiation‐based adoptive transfer, parabiosis transgenic mice have limitations. We aimed to develop novel nonmyeloablative transplantation NMT mouse model that permits high levels of peripheral chimerism without...
Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low chimerism levels, blood-brain barrier disruption and pro-inflammatory effects prior to progression of pathological phenotype, make it difficult distinguish role cells neuroinflammatory conditions. Head-shielded irradiation overcomes many issues described replaces recipient system with donor haematopoietic expressing a reporter gene or...
The requirement for training surgical procedures without exposing the patient to additional risk is well accepted and part of a national drive in UK internationally. Computer-based simulations are important this context, including neurosurgical resident training. objective study evaluate effectiveness custom-built virtual environment assisting ventriculostomy procedure. tool (called VCath) has been developed as an app tablet platform provide easy access availability trainees. was conducted...
Background Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment well established, however disease invariably recurs and improving prognosis challenging. With aim of personalizing therapy at recurrence, we have established a high content screening (HCS) platform to analyze sensitivity profile seven patient-derived cancer stem cell lines 83 FDA-approved chemotherapy drugs, with without irradiation. Methods Seven were...
We have previously investigated the effectiveness of a custom-built virtual environment in assisting training ventriculostomy procedure, which is commonly performed procedure by neurosurgeon and core task for trainee surgeons. The tool (called VCath) was initially developed as low-fidelity app tablet platform to provide easy access availability trainees. Subsequently, we high-fidelity version VCath that uses stereoscopic display immerse environment. This article reports on two studies been...
In an exploratory subanalysis of the European Organisation for Research and Treatment Cancer National Institute Canada (EORTC/NCIC) trial data, Gorlia et al. identified a variety factors that were predictive overall survival, including therapy administered, age, extent surgery, mini-mental score, administration corticosteroids, World Health Organization (WHO) performance status, O-methylguanine-DNA methyltransferase (MGMT) promoter methylation status. developed 3 nomograms, each intended to...
Over the last 20 years, several intraoperative adjuncts, including ultrasonography, neuronavigation, and angiography, have been said to aid localization resection of cerebral arteriovenous malformations (AVMs). The authors assessed value Doppler ultrasonography in conjunction with neuronavigation during surgery for AVMs pediatric population.The reviewed all cranial AVM resections performed by a single surgeon at their institution period from 2007 2013 here describe experience results series...