A5041762870- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
- CAR-T cell therapy research
- Planarian Biology and Electrostimulation
- Meningioma and schwannoma management
- Child and Adolescent Health
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Neurological Complications and Syndromes
- Obesity and Health Practices
- Neuroblastoma Research and Treatments
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
Royal Manchester Children's Hospital
2014-2024
Manchester University NHS Foundation Trust
2023
University of Manchester
2015-2023
Brain Tumour Research
2018
LGBT Foundation
2015
Allogeneic hematopoietic cell transplantation (HCT) is the only treatment able to prevent progressive neurodegenerative disease in a selected group of mucopolysaccharidosis (MPS) disorders. However, its use was historically limited by high risk graft failure and transplantation-related morbidity mortality. Therefore, since 2005 new international HCT guidelines for MPS disorders were proposed. The survival outcomes patients receiving according these 2 European centers expertise evaluated. Two...
A major goal in regenerative medicine is to identify therapies facilitate our body׳s innate abilities repair and regenerate following injury, disease or aging. In the past decade it has become apparent that immune system able affect speed quality of response through mechanisms are not entirely clear. For this reason there been a resurgent interest investigating role inflammation during tissue regeneration. Remarkably, have only handful such studies using organisms with high capacity. Here we...
Craniopharyngiomas are one of the most frequently diagnosed hypothalamo-pituitary tumors in childhood. The adamantinomatous histological subtype accounts for pediatric cases, while papillary variant is almost exclusively adults. Here, we report a case craniopharyngioma very young child, confirmed by molecular tissue analysis. A 4-year-old girl was being investigated symptomatic central hypothyroidism. Brain MR imaging revealed large solid/cystic suprasellar mass, splaying optic chiasm and...
In vivo T-cell depletion, using alemtuzumab therapy prior to SCT, can reduce the incidence of GVHD. This treatment has a potential delay immune reconstitution resulting in increased morbidity due viral illnesses. We retrospectively analyzed data on all pediatric patients with non-malignant disorders who received alemtuzumab-based conditioning regimens our center over last 10 yr (n = 91). Our show an OS 91.2%. The acute (grade 2-4) GVHD was 18.7% and that chronic 5.5%. Viremia adenovirus, EBV...
In high-risk myeloid malignancy, relapse is reduced using cord blood transplant (CBT) but remains the principal cause of treatment failure. We previously described T-cell expansion in CBT recipients receiving granulocyte transfusions. now report safety and tolerability such transfusions, data, immunophenotype, cytokine profiles clinical response children with post-transplant relapsed acute leukaemia who received T-replete, HLA-mismatched pooled granulocytes within a phase I/II trial...
Allogeneic hematopoietic cell transplantation (HCT) is the only treatment option able to prevent progressive neurodegenerative disease in a selected group of mucopolysaccharidoses (MPS) disorders. However, its use was historically limited by high risk graft failure and HCT-related morbidity mortality. Therefore 2005, European Blood Marrow Transplantation developed guidelines for HCT MPS patients. We prospectively evaluated outcomes patients, complying with these international two centers...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
We report a four year old girl with autistic spectrum disorder who was being investigated for symptomatic central hypothyroidism and potential growth hormone deficiency. Brain MR imaging revealed large solid / cystic suprasellar mass, splaying the optic chiasm measuring 3 x 1.9 2.3 centimeters. The pituitary obscured, other than small portion of infundibulum. patient underwent transphenoidal near total resection lesion, necrotic cream-like material encountered within tumour bed....