A5066227746- Childhood Cancer Survivors' Quality of Life
- Reproductive Biology and Fertility
- Primary Care and Health Outcomes
- Hematopoietic Stem Cell Transplantation
- Emergency and Acute Care Studies
- Cancer Risks and Factors
- Mental Health Treatment and Access
- Health, psychology, and well-being
- Virus-based gene therapy research
- Family Support in Illness
- Language Development and Disorders
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Neurogenetic and Muscular Disorders Research
- Autoimmune and Inflammatory Disorders Research
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Child and Adolescent Psychosocial and Emotional Development
- Immunodeficiency and Autoimmune Disorders
- Organizational Learning and Leadership
- Psychiatric care and mental health services
- Cytomegalovirus and herpesvirus research
- Healthcare Policy and Management
Royal Manchester Children's Hospital
2020-2023
Manchester University NHS Foundation Trust
2023
Johannes Gutenberg University Mainz
2021
Boyne Research Institute
2018-2020
University of British Columbia
2017-2018
Island Health
2008-2017
University of Victoria
2017
Analytical Services
2011
Birmingham and Solihull Mental Health NHS Foundation Trust
2005
Brunel University of London
2001-2003
Which chemotherapeutic agents and body site-specific radiation fields are dose-dependently associated with an increased risk of fertility impairment in long-term female childhood, adolescent young adulthood (CAYA) cancer survivors?
Objective: Most interventions to reduce stigma in health professionals emphasize education and social contact–based strategies. We sought evaluate a novel skill-based approach: the British Columbia Adult Mental Health Practice Support Program. determine program’s impact on primary care providers’ their perceived confidence comfort providing for mentally ill patients. hypothesized that enhanced skills increased part of practitioners would lead diminished distance stigmatization. Subsequently,...
Abstract Background Wolman disease is a rare, lysosomal storage disorder in which biallelic variants the LIPA gene result reduced or complete lack of acid lipase. The accumulation substrates; cholesterol esters and triglycerides, significantly impacts cellular function. Untreated patients die within first 12 months life. Clinically, present severely malnourished, with diarrhoea hepatosplenomegaly, many have an inflammatory phenotype, including hemophagocytic lymphohistiocytosis (HLH)....
Improved risk stratification, more effective therapy and better supportive care have resulted in survival rates after childhood cancer of around 80% developed countries. Treatment however can be harsh, three every four survivors (CCS) develop at least one late effect, such as gonadal impairment. Gonadal impairment cause involuntary childlessness, with serious consequences for the well-being CCS. In addition, early menopause increases comorbidities cardiovascular disease osteoporosis....
Despite a significant number of studies on female fertility following childhood, adolescent, and young adult (CAYA) cancer, establishing precise (dose-related) estimates treatment-related risks are still scarce. Previous have been underpowered, did not include detailed treatment information, or were based self-report only without any hormonal assessments. More assessments who is at risk for sub- infertility needed.The objective our study to describe the design methods 2 (a cohort nested...
Objectives: To examine whether, from a National Health Service (NHS) and local authority social services' viewpoint, hospital-at-home service was cost saving compared with conventional inpatient care. Methods: The subjects of this part-retrospective part-prospective analysis were 51 elderly medical orthopaedic surgical patients assessed at Hillingdon Hospital, West London, as being suitable for Thirty received care, provided up to 14 days, while 21 remained in hospital standard All direct...
This article describes a new and innovative training program to assist family physicians better care for their patients with mental health conditions.Trained physician leaders train other physicians.The package includes wide range of tools that can be used by in own offices.Preliminary results indicate want trained, data high degree success the module.Some 91% who attended indicated it had improved practice, 94% patient care.The materials are online those wish learn more.M ental conditions...
Disparities in survival after breast cancer persist. Cancer registry data that are often used to assess associated factors only explain some of the differences. The purpose this study was obtain information from disadvantaged Irish women concerning possible barriers care for above and beyond risk collected by registries. We a qualitative interview with treatment cancer, following methods thematic analysis. Important themes potentially related disparity occurred each phase. Before diagnosis...
In high-risk myeloid malignancy, relapse is reduced using cord blood transplant (CBT) but remains the principal cause of treatment failure. We previously described T-cell expansion in CBT recipients receiving granulocyte transfusions. now report safety and tolerability such transfusions, data, immunophenotype, cytokine profiles clinical response children with post-transplant relapsed acute leukaemia who received T-replete, HLA-mismatched pooled granulocytes within a phase I/II trial...
Objective As adolescent cancer patients may suffer from infertility following treatment, fertility counselling is essential. Our aim was to explore the current situation in four European countries terms of (I) education about risk for infertility, (II) on preservation, (III) patients' knowledge fertility, (IV) sufficiency information and (V) uptake cryopreservation. Methods In total, 113 (13–20 years) at 11 study centres completed a self-report questionnaire three six months after diagnosis....
Aims and Method A cross-sectional survey was conducted to investigate the safety of rooms used by medical staff interview patients in out-patient in-patient settings a mental health trust. An assessment tool designed, examined features an room that were likely promote safety. Results The included 112 demonstrated shortcomings compromised Rooms frequently overcrowded with furniture ( n =30), cluttered loose objects n= 101, 90%) for multiple purposes =82, 73%). Room layout often either access...
Depression affects over 400 million people globally. The majority are seen in primary care. Barriers providing adequate care not solely related to physicians' knowledge/skills deficits, but also time constraints, lack of confidence/avoidance, which need be addressed mental health-care redesign. We hypothesized that family physician (FP) training the Adult Mental Health Practice Support Program (AMHPSP) would lead greater improvements patient depressive symptom ratings (a priori outcome)...
Abstract Umbilical cord blood is the preferred donor cell source for children with Inherited Metabolic disorders undergoing Hematopoietic Cell Transplant (HCT), and its use has been associated improved “engrafted survival” higher chimerism compared to other sources. However, as in pediatric transplants non-malignant disease, immune-mediated cytopenia primary graft failure limit use, latter remains commonest cause of death following transplant disease. We have previously shown an association...
Summary As a result of the rapid growth applied psycholinguistic research it is necessary to explode some myths normal and abnormal speech development. The following paper an attempt clarify nature phonological development disability draw general implications for assessment management unintelligible child.
Many patients with mental illness depend on family physicians (FPs) for their physical and health care, yet FPs often report dissatisfaction the quality of care they provide. A 2-year, improvement (QI) manual-based initiative was developed to increase FPs' diagnostic, cognitive-behavioural, interpersonal treatment skills depression. Two teams, each consisting a psychiatrist therapist, rotated through 18 practices in Victoria, British Columbia, mentoring model on-site patients. Feedback...
This study investigates the nature of phonological simplifications seen in speech preschool children, by analysing effect stress position, phonetic environment and relative recency sound acquisition, on accuracy production initial consonant cluster within a word. Forty, 4-year-old took part an imitation task consisting 44 three syllable nonsense words, half which began with early developing late cluster. Both halves contained word pairs first second stress. Half subjects repeated words...
<sec> <title>BACKGROUND</title> Despite a significant number of studies on female fertility following childhood, adolescent, and young adult (CAYA) cancer, establishing precise (dose-related) estimates treatment-related risks are still scarce. Previous have been underpowered, did not include detailed treatment information, or were based self-report only without any hormonal assessments. More assessments who is at risk for sub- infertility needed. </sec> <title>OBJECTIVE</title> The objective...
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