A5068857486- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Radiation Therapy and Dosimetry
- Family Support in Illness
- Effects of Radiation Exposure
- Cancer Risks and Factors
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Thyroid Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Advanced Radiotherapy Techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Renal and related cancers
- Head and Neck Cancer Studies
- BRCA gene mutations in cancer
- Reproductive Biology and Fertility
- Global Cancer Incidence and Screening
- Brain Metastases and Treatment
- Cancer survivorship and care
- Frailty in Older Adults
- Adolescent and Pediatric Healthcare
- Nutrition and Health in Aging
- Oral health in cancer treatment
- Multiple and Secondary Primary Cancers
University Medical Center of the Johannes Gutenberg University Mainz
2023-2025
Johannes Gutenberg University Mainz
2023-2025
Princess Máxima Center
2015-2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2025
Medizinische Hochschule Brandenburg Theodor Fontane
2020-2024
Carl von Ossietzky Universität Oldenburg
2022-2024
Division of Cancer Epidemiology and Genetics
2003-2023
Emma Kinderziekenhuis
2014-2023
Amsterdam UMC Location University of Amsterdam
2014-2023
Stichting Kinderoncologie Nederland
2009-2023
Although CT scans are very useful clinically, potential cancer risks exist from associated ionising radiation, in particular for children who more radiosensitive than adults. We aimed to assess the excess risk of leukaemia and brain tumours after a cohort young adults.In our retrospective study, we included patients without previous diagnoses were first examined with National Health Service (NHS) centres England, Wales, or Scotland (Great Britain) between 1985 2002, when they younger 22...
Computed tomography (CT), a strong diagnostic tool, delivers higher radiation doses than most imaging modalities. As CT use has increased rapidly, protection is important, particularly among children. We evaluate leukemia and brain tumor risk following exposure to low-dose ionizing from scans in childhood.For nationwide retrospective cohort of 168 394 children who received one or more Dutch hospital between 1979 2012 were younger age 18 years, we obtained cancer incidence, vital status,...
Previous studies have indicated that thyroid cancer risk after a first childhood malignancy is curvilinear with radiation dose, increasing at low to moderate doses and decreasing high doses. Understanding factors modify the dose response over entire therapeutic range challenging requires large numbers of subjects. We quantified long-term associated treatment among 12,547 5-year survivors (leukemia, Hodgkin lymphoma non-Hodgkin lymphoma, central nervous system cancer, soft tissue sarcoma,...
Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term of SMNs in a well-characterized cohort 5-year CCSs, with particular focus on individual chemotherapeutic agents and solid risk. Methods The Dutch Cancer Oncology Group-Long-Term Effects After includes 6,165 CCSs diagnosed between 1963 2001 Netherlands. were identified by linkages Netherlands Registry, Pathology medical chart review. calculated standardized...
Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent examinations before age 22 years in nine countries. Radiation doses the active bone marrow were estimated on basis body part scanned, patient...
To determine the risk of subsequent carcinomas other than breast, thyroid, and skin, to identify factors that influence among survivors childhood cancer.Subsequent malignant neoplasm history was determined in 13,136 participants (surviving > or = 5 years postmalignancy, diagnosed from 1970 1986 at age < 21 years) Childhood Cancer Survivor Study calculate standardized incidence ratios (SIRs), using Surveillance, Epidemiology, End Results data.In 71 individuals, were a median 27 elapsed time...
We studied cancer mortality in a cohort of 5,573 women with scoliosis and other spine disorders who were diagnosed between 1912 1965 exposed to frequent diagnostic X-ray procedures. Patients identified from medical records 14 orthopedic centers the United States followed for vital status address through December 31, 2004, using publicly available regional, state nationwide databases. Causes death obtained certificates or linkage National Death Index (NDI). Statistical analyses included...
Abstract Background: Ionizing radiation is a well-established human mammary carcinogen. Women historically monitored by radiography at young ages for abnormal spinal curvature are an exposed population suitable investigating radiation-related risk and its variation modifying factors. In this historic cohort, 95% of daily dose increments (when exposure to the breast occurred) were under 2.4 cGy, with mean 1.1 cGy. Methods: A retrospective cohort 3,010 women, diagnosed between 1912 1965 in 14...
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors childhood cancer. Patients Methods Participants the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for development stroke. Siblings (n 4,023) established baseline population risk. Piecewise exponential models with backward selection estimated relationships between potential predictors each outcome. The St Jude Lifetime Cohort 1,842) Emma Children’s...
Abstract Background: Although ionizing radiation is an established environmental risk factor for thyroid cancer, the effect of chemotherapy drugs on cancer remains unclear. We evaluated chemotherapy-related in childhood survivors and possible joint effects radiotherapy. Methods: The study included 12,547 five-year diagnosed during 1970 through 1986. Chemotherapy radiotherapy information was obtained from medical records, dose estimated to gland. Cumulative incidence relative risks were...
With the advent of multimodality therapy, overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort survivors, with many years life ahead them, raised necessity for knowledge concerning risks adverse long-term sequelae life-saving treatments order to provide optimal screening and care identify adequate interventions. Childhood survivor cohorts Europe. Considerable advantages exist study late effects...
Background: Recently, the International Agency for Research on Cancer (IARC) Programme Evaluation of Carcinogenic Risks to Humans has been criticized several its evaluations, and also approach used perform these evaluations. Some critics have claimed that failures IARC Working Groups recognize study weaknesses biases Group members led inappropriate classification a number agents as carcinogenic humans.Objectives: The authors this Commentary are scientists from various disciplines relevant...
Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals this study were to evaluate risk heart failure, temporal changes by periods, and factors childhood survivors ( CCS ). Methods Results DCOG‐LATER (Dutch Childhood Oncology Group–Long‐Term Effects After Cancer) cohort includes 6,165 5‐year diagnosed between 1963 2002. Details on prior diagnosis collected nationwide cohort. Cause‐specific cumulative incidences obtained. Cardiac...
BackgroundCurrently, there are between 300,000 and 500,000 childhood cancer survivors (CCSs) in Europe. A significant proportion is at high risk, least 60% of them develop adverse health-related outcomes that can appear several years after treatment completion. Many unaware their personal seems to be a general lack information among healthcare providers about pathophysiology natural history treatment-related complications. This generate incorrect or delayed diagnosis treatments.MethodThe...
As new evidence is available, the International Late Effects of Childhood Cancer Guideline Harmonization Group has updated breast cancer surveillance recommendations for female survivors childhood, adolescent, and young adult cancer.