A5045217837- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Renal and related cancers
- FOXO transcription factor regulation
- Sarcoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Radiation Therapy and Dosimetry
- Testicular diseases and treatments
- Cancer Risks and Factors
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Ethics and Legal Issues in Pediatric Healthcare
- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Neonatal Respiratory Health Research
- Effects of Radiation Exposure
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Family Support in Illness
Nationwide Children's Hospital
2009-2023
University of Manitoba
2018
Flinders University
2018
The Ohio State University
2006-2017
Ohio University
2016
Fred Hutch Cancer Center
2001-2015
University of Chicago
2007-2015
St. Jude Children's Research Hospital
2006-2015
Memorial Sloan Kettering Cancer Center
2010-2015
Cancer Research Center
2001-2014
Background: Because survival rates among childhood cancer patients are increasing, assessing the risk of second and subsequent malignant neoplasms (SMNs) is ever more important. Using Childhood Cancer Survivor Study cohort, we identified SMNs. Methods: A retrospective cohort 13 581 children diagnosed with common cancers before age 21 years surviving at least 5 was constructed use data from treated 25 U.S. Canadian institutions. SMNs were ascertained through self-administered questionnaires...
BackgroundThe occurrence of subsequent neoplasms has direct impact on the quantity and quality life in cancer survivors. We have expanded our analysis these events Childhood Cancer Survivor Study (CCSS) to better understand as survivor population ages.
Background: Subsequent primary neoplasms of the central nervous system (CNS) have frequently been described as late events following childhood leukemia and brain tumors. However, details dose–response relationships, expression excess risk over time, modifying effects other host treatment factors not well defined. Methods: CNS occurring within a cohort 14 361 5-year survivors cancers were ascertained. Each patient was matched with four control subjects by age, sex, time since original cancer...
The risk of breast cancer is high in women treated for a childhood with chest irradiation. We sought to examine variations resulting from irradiation field and radiation dose.
Previous studies have indicated that thyroid cancer risk after a first childhood malignancy is curvilinear with radiation dose, increasing at low to moderate doses and decreasing high doses. Understanding factors modify the dose response over entire therapeutic range challenging requires large numbers of subjects. We quantified long-term associated treatment among 12,547 5-year survivors (leukemia, Hodgkin lymphoma non-Hodgkin lymphoma, central nervous system cancer, soft tissue sarcoma,...
<h3>Importance</h3> Cancer treatments are associated with subsequent neoplasms in survivors of childhood cancer. It is unknown whether temporal changes therapy neoplasm risk. <h3>Objective</h3> To quantify the association between treatment dosing and <h3>Design, Setting, Participants</h3> Retrospective, multicenter cohort study 5-year cancer diagnosed before age 21 years from pediatric tertiary hospitals United States Canada 1970-1999, follow-up through December 2015. <h3>Exposures</h3>...
To determine the risk of subsequent carcinomas other than breast, thyroid, and skin, to identify factors that influence among survivors childhood cancer.Subsequent malignant neoplasm history was determined in 13,136 participants (surviving > or = 5 years postmalignancy, diagnosed from 1970 1986 at age < 21 years) Childhood Cancer Survivor Study calculate standardized incidence ratios (SIRs), using Surveillance, Epidemiology, End Results data.In 71 individuals, were a median 27 elapsed time...
The purpose of this study was to quantify the risk breast cancer in relation radiation dose and chemotherapy among survivors childhood cancer.We conducted a case-control cohort 6,647 women who were 5-year treated during 1970 through 1986. One hundred twenty patients with histologically confirmed identified individually matched four selected controls on age at initial time since cancer. Medical physicists estimated tumor site ovaries basis medical records.The odds ratio for increased linearly...
Childhood cancer survivors are at increased risk for the development of secondary sarcomas. Exposure to radiation therapy is a known factor these Other factors sarcomas have not been well described childhood survivors. We analyzed large cohort determine true incidence and examine associated with developing The history in 14 372 participants Cancer Survivor Study was determined from self-reports three questionnaires. Risk sarcoma evaluated by use standardized ratios (SIRs) excess absolute...
The survival of Ewing sarcoma (ES) patients has improved since the 1970s but is associated with considerable future health risks. study population consisted long-term (≥5-year) survivors childhood ES diagnosed before age 21 from 1970 to 1986. Cause-specific mortality was evaluated in eligible (n = 568), and subsequent malignant neoplasms, chronic conditions, infertility, status were subset participating Childhood Cancer Survivor Study 403). Outcomes compared US sibling control subjects...
Purpose Childhood cancer survivors experience an increased incidence of subsequent neoplasms (SNs). Those surviving the first SN (SN1) remain at risk to develop multiple SNs. Because SNs are a common cause late morbidity and mortality, characterization rates is needed. Patients Methods In total 14,358 5-year childhood diagnosed between 1970 1986, analyses were carried out among 1,382 with SN1. Cumulative second neoplasm (SN2), either malignant or benign, was calculated. Results A (9.6%)...
Background: Childhood cancer survivors develop gastrointestinal more frequently and at a younger age than the general population, but risk factors have not been well-characterized. Objective: To determine associated for subsequent malignant neoplasms (SMNs) in childhood survivors. Design: Retrospective cohort study. Setting: The Cancer Survivor Study, multicenter study of diagnosed between 1970 1986. Patients: 14 358 when they were 21 years who survived 5 or after initial diagnosis....
Abstract Background: Although ionizing radiation is an established environmental risk factor for thyroid cancer, the effect of chemotherapy drugs on cancer remains unclear. We evaluated chemotherapy-related in childhood survivors and possible joint effects radiotherapy. Methods: The study included 12,547 five-year diagnosed during 1970 through 1986. Chemotherapy radiotherapy information was obtained from medical records, dose estimated to gland. Cumulative incidence relative risks were...
Nonmelanoma skin cancer (NMSC) has become the most common type of in many populations throughout world. Ultraviolet and ionizing radiation are known risk factors. Because NMSCs rarely lethal registries do not routinely report data regarding these cancers, they have received little attention studies evaluating long-term effects therapy. This article reports on occurrence secondary NMSC as a effect therapy survivors childhood cancer.The Childhood Cancer Survivor Study (CCSS) is cohort study...
Ronckers, C. M., Sigurdson, A. J., Stovall, Smith, S. A., Mertens, C., Liu, Y., Hammond, S., Land, E., Neglia, J. P., Donaldson, Meadows, T., Sklar, Robison, L. and Inskip, P. D. Thyroid Cancer in Childhood Survivors: A Detailed Evaluation of Radiation Dose Response its Modifiers. Radiat. Res. 166, 618–628 (2006).Radiation exposure at a young age is strong risk factor for thyroid cancer. We conducted nested case-control study 69 cancer cases 265 controls from cohort 14,054 childhood...
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, but no safe effective RSV vaccine yet available. For reasons that are not well understood, only weakly immunogenic, reinfection occurs throughout life. This has complicated search for an live attenuated viral vaccine, past trials with inactivated preparations have led to enhanced immunopathology following natural infection. We tested hypothesis weak stimulation innate...
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer that related to the skeletal muscle lineage and characterized by recurrent chromosomal translocations. Within ARMS category, there clinical genetic heterogeneity, consistent with premise "primary" events collaborate "secondary" give rise subsets varying features. Previous studies demonstrated genomic amplification occurs frequently in ARMS. In current study, we used oligonucleotide arrays localize two common amplicons 2p24...
Little is known about the breast cancer risk among childhood survivors who did not receive chest radiotherapy. We sought to determine magnitude of and associated factors for these women.We evaluated cumulative in 3,768 female without a history radiotherapy were participants Childhood Cancer Survivor Study.With median follow up 25.5 years (range, 8 39 years), 47 women developed at age 38.0 22 years) 24.0 10 34 from primary cancer. A four-fold increased (standardized incidence ratio [SIR] =...