Lin Fritschi
A5007608967- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Occupational Health and Safety Research
- Carcinogens and Genotoxicity Assessment
- Occupational exposure and asthma
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Sleep and Work-Related Fatigue
- Noise Effects and Management
- Agriculture and Farm Safety
- Circadian rhythm and melatonin
- Childhood Cancer Survivors' Quality of Life
- Radiation Dose and Imaging
- Pesticide Exposure and Toxicity
- Skin Protection and Aging
- Genetic Associations and Epidemiology
- Veterinary Practice and Education Studies
- Sleep and related disorders
- Indoor Air Quality and Microbial Exposure
- Cutaneous Melanoma Detection and Management
- Nutrition and Health in Aging
Curtin University
2016-2025
Centre International de Recherche sur le Cancer
2024
Harry Perkins Institute of Medical Research
2007-2023
The University of Western Australia
2009-2023
Faculty of Public Health
2023
Monash University
1997-2018
The Alfred Hospital
1997-2018
The University of Sydney
2005-2018
Monash Alfred Psychiatry Research centre
2018
Utrecht University
2018
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Based on the idea that electric light at night might account for a portion of high and rising risk breast cancer worldwide, it was predicted long ago women working non-day shift would be higher compared with day-working women. This hypothesis has been extended more recently to prostate cancer. On basis limited human evidence sufficient in experimental animals, 2007 International Agency Research Cancer (IARC) classified 'shift work involves circadian disruption' as probable carcinogen, group...
Background: Self-report remains the most practical and cost-effective method for epidemiologic sleep studies involving large population-based samples. Several validated questionnaires have been developed to assess sleep, but these tools are lengthy administer may be impractical studies. We examined whether a 3-item questionnaire, similar those typically used in studies, closely corresponded with objective measures of as assessed using actigraphy monitoring.Methods: Eligible participants were...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, physical biological agents that cause cancer in humans has evaluated about 1000 since 1971. are written by ad hoc Working Groups (WGs) of international scientific experts over a period 12 months ending an eight-day meeting. WG evaluates all the publicly available information each substance and, through transparent rigorous...
Men who were part of an Australian petroleum industry cohort had previously been found to have excess lympho-hematopoietic cancer. Occupational benzene exposure is a possible cause this excess.We conducted case-control study cancer nested within the existing examine role exposure. Cases identified between 1981 and 1999 (N = 79) age-matched 5 control subjects from cohort. We estimated each subject's using occupational histories, local site-specific information, algorithm monitoring...
The role of occupational substances as stomach carcinogens has not been well investigated. In 1979, a population-based case-control study was undertaken in Montreal to explore the possible association between hundreds circumstances and several cancer sites, including stomach. total, 250 male patients with pathologically confirmed cancer, 2,289 controls cancers at other 533 were interviewed obtain detailed job histories relevant data on potential confounders. Job evaluated by expert chemists...
Background Smoking is considered to be a risk factor for patients undergoing surgery and anesthesia, but it unclear whether this applicable ambulatory surgery. The aim of study was determine the respiratory complications wound infection among smokers. Methods authors studied random selection 489 adult status determined by self-report confirmed with end-expired carbon monoxide analysis. (i.e., desaturation, cough, laryngospasm, bronchospasm, breath-holding, or apnea) redness discharge +/-...
<h3>Importance</h3> Merkel cell carcinoma (MCC) is an uncommon but highly invasive form of skin cancer. The mechanisms that cause MCC are yet to be fully determined. <h3>Objectives</h3> To compare the incidence and survival rates in Queensland, Australia, known a high-risk area, with elsewhere world. We also analyzed trends differences by key demographic clinical characteristics. <h3>Design, Setting, Participants</h3> Retrospective cohort study population-based administrative data for...
To estimate the proportion and numbers of cancers occurring in Australia attributable to solar ultraviolet radiation (UVR) prevented by regular sun protection factor (SPF) 15+ sunscreen use.
In recent years, reduced participation has been encountered across all epidemiological study designs, both in terms of non-response as well refusal. A low response rate may reduce the statistical power but, more importantly, results not be generalizable to wider community. a telephone survey 1413 randomly selected members Australian general population and 690 participants sourced from previous studies, we examined factors affecting people's stated willingness participate health research. The...
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control in Childhood Leukemia International Consortium. Exposure were harmonized into compatible formats. Pooled analyses undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with...
Patients with chronic lymphocytic leukaemia (CLL) are known to have increased risks of second cancer. The incidence cancers after CLL has not been reported in detail for Australia, a country particularly high levels ultraviolet radiation (UVR).The study cohort comprised all people diagnosed primary between 1983 and 2005 Australia. Standardised ratios (SIRs) standardised mortality (SMRs) were calculated using Australian population rates.Overall, the risk any incident cancer was more than...
The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures scientific review and evaluation of carcinogenic hazards independent experts. Preamble to IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations a 2018 expert advisory group. This article presents key features Preamble, major milestone that will enable take advantage recent procedural advances made during 12 years since last amendments....
Background: Recently, the International Agency for Research on Cancer (IARC) Programme Evaluation of Carcinogenic Risks to Humans has been criticized several its evaluations, and also approach used perform these evaluations. Some critics have claimed that failures IARC Working Groups recognize study weaknesses biases Group members led inappropriate classification a number agents as carcinogenic humans.Objectives: The authors this Commentary are scientists from various disciplines relevant...
To estimate the numbers and proportions of cancers occurring in Australia 2010 attributable to modifiable causal factors. We estimated population fraction (PAF) associated with exposure 13 factors using standard formulae incorporating prevalence relative risk data. also calculated potential impact changing some A total 32% all diagnosed (excluding keratinocyte cancers) were assessed (men 33%; women 31%). Leading tobacco smoke (PAF cancers: 13.4%), solar radiation (6.2%), inadequate diet...