A5027760913- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Palliative Care and End-of-Life Issues
- Global Cancer Incidence and Screening
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Carcinogens and Genotoxicity Assessment
- Cancer survivorship and care
- Electromagnetic Fields and Biological Effects
- Radiation Dose and Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
University of York
2016-2025
University Hospitals of Cleveland
2024
University of Leeds
1997-2022
Mayo Clinic in Florida
2021
Department of Medical Sciences
2019
Yorkshire Cancer Research
2017
University of California, Berkeley
1999-2016
ORSI Academy
2016
NYU Langone Health
2016
National Cancer Institute
2000-2015
Previous studies have suggested an association between exposure to 50–60 Hz magnetic fields (EMF) and childhood leukaemia. We conducted a pooled analysis based on individual records from nine studies, including the most recent ones. Studies with 24/48-hour field measurements or calculated were included. specified which data analyses we planned do how them before commenced work. The use of allowed us same definitions, large numbers subjects enabled more precise estimation risks at high...
Ascertainment of cases and disease classification is an acknowledged problem for epidemiological research into haematological malignancies. The Haematological Malignancy Research Network comprises ongoing population-based patient cohort. All diagnoses (paediatric adult) across two UK Cancer Networks (population 3.6 million, >2000 annually, socio-demographically representative the UK) are made by integrated haematopathology laboratory. Diagnostics, prognostics, treatment recorded to clinical...
Rearrangement of MYC occurs in a proportion diffuse large B-cell lymphomas (DLBCL), where they may be associated with an adverse clinical outcome. The aim this study was to determine the frequency translocations DLBCL and their prognostic impact era cyclophosphamide, doxorubicin, vincristine, prednisone plus rituximab (CHOP-R) therapy.Three hundred three patients previously untreated DLBCL, no evidence underlying follicular lymphoma, were investigated using immunohistochemistry interphase...
Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, 5-methyltetrahydrofolate (methylTHF), the primary methyl methionine is catalyzed by reductase (MTHFR). A common 677 C → T polymorphism MTHFR gene results thermolability and reduced activity that decreases pool methylTHF increases methyleneTHF. Recently, another (1298 C) has been identified also diminished enzyme activity. We tested whether carriers these variant alleles are...
Population-based information about cancer occurrence and survival are required to inform clinical practice research; but for most lymphomas data lacking. Set within a socio-demographically representative UK population of nearly 4 million, lymphoma (N=5796) from an established patient cohort. Incidence, (overall relative) prevalence estimates >20 subtypes presented. With few exceptions, males tended be diagnosed at younger ages have significantly (P<0.05) higher incidence rates. Differences...
Glutathione S -transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some which are suspected human carcinogens. Functional polymorphisms exist in at least three genes that encode GSTs, GSTM1, GSTT1, GSTP1. We hypothesize, therefore, GSTs alter susceptibility to chemotherapy-induced carcinogenesis, specifically therapy-related acute myeloid leukemia (t-AML), a devastating complication long-term...
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation an independent replication series, to identify common genetic variants associated total subtypes defined EBV Multiple logistic regression was used calculate...
The Haematological Malignancy Research Network (HMRN) was established in 2004 to provide robust generalizable data inform clinical practice and research. It comprises an ongoing population-based cohort of patients newly diagnosed by a single integrated haematopathology laboratory two adjacent UK Cancer Networks (population 3.6 million). With emphasis on primary-source data, prognostic factors, sequential treatment/response history, socio-demographic details are recorded trial standards. Data...
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants added to previous data (patients diagnosed from 1989 2005 14 case-control studies; 7,999 cases, 8,452 controls) for testing of the TNF –308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10 –3575T>A (rs1800890, rs1800896),...
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control in Childhood Leukemia International Consortium. Exposure were harmonized into compatible formats. Pooled analyses undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with...