A5029391119- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Cancer Risks and Factors
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Vascular Malformations Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Vascular Malformations and Hemangiomas
- Neurofibromatosis and Schwannoma Cases
- Family Support in Illness
- Ethics and Legal Issues in Pediatric Healthcare
- Protein Degradation and Inhibitors
- Cardiac tumors and thrombi
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Neutropenia and Cancer Infections
National and Kapodistrian University of Athens
2015-2025
Iaso Children’s Hospital
2011-2025
Children's Hospital Agia Sophia
2006-2024
Senologic Hellenic Society
2022
University of Ottawa
2021
Instituto Nacional do Câncer
2020
Athens State University
2004-2017
University of California, Berkeley
2016
University Hospital of Heraklion
2015
Boston Children's Hospital
2002-2014
Purpose A balanced chromosomal translocation, t(15;19), resulting in the BRD4-NUT oncogene, has been identified a lethal carcinoma of young people, disease described primarily case reports. We sought to amass more definitive series tumors with NUT and/or BRD4 gene rearrangements and determine distinct clinicopathologic features. Patients Methods Carcinomas (N = 98) individuals (median age, 32.5 years) were screened for using dual-color fluorescence situ hybridization. Four published...
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control in Childhood Leukemia International Consortium. Exposure were harmonized into compatible formats. Pooled analyses undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with...
Maternal prenatal supplementation with folic acid and other vitamins has been inconsistently associated a reduced risk of childhood acute lymphoblastic leukemia (ALL). Little is known regarding the association myeloid (AML), rarer subtype.We obtained original data on use from 12 case-control studies participating in Childhood Leukemia International Consortium (enrollment period: 1980-2012), including 6,963 cases ALL, 585 AML, 11,635 controls. Logistic regression was used to estimate pooled...
To investigate the presence of early indicators dysmetabolic syndrome (DS) in young survivors with acute lymphoblastic leukemia (ALL) childhood.We enrolled 80 patients ALL (50 males, median age 13.9 y, interval since completion chemotherapy 6.3 y). Sixty-two (group A) received only, whereas 18 B) and cranial irradiation (18 Gy).Frank obesity [25%; confidence (CI) 95%, 16.7%-35.6%], increased blood pressure (21%; CI 13.6%-31.5%), serum triglycerides reduced high-density lipoprotein...
Abstract Background Cancer risk in children born after vitro fertilization (IVF) remains largely unknown. We aimed to investigate of leukemia and lymphoma following IVF using two nationwide datasets. Methods The hospital‐based case–control study Greece derived from the National Registry for Childhood Hematological Malignancies (1996–2008, 814 277 incident cases with their 1:1 matched controls). Swedish was nested Medical Birth Register (MBR) (1995–2007, 520 71 5,200 710 controls)...
Abstract Rhabdoid tumours (RT) are an aggressive malignancy affecting <2‐year‐old infants, characterised by biallelic loss‐of‐function alterations in SWI/SNF‐related BAF chromatin remodelling complex subunit B1 ( SMARCB1 ) nearly all cases. Germline found ~30% of patients and define the RT Predisposition Syndrome type 1 (RTPS1). Uveal melanoma (UVM), most common primary intraocular cancer adults, does not harbour alterations. We report two cases a previously undescribed that shared some...
In recent decades, the possibility that use of mobile communicating devices, particularly wireless (mobile and cordless) phones, may increase brain tumour risk, has been a concern, given considerable in their by young people. MOBI-Kids, 14-country (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, Netherlands, New Zealand, Spain) case-control study, was conducted to evaluate whether phone (and resulting exposure radiofrequency (RF) extremely low...
To investigate adipocytokine secretion, at diagnosis and during chemotherapy in children with the acute lymphoblastic leukemia (ALL).Serial measurements (6/patient) of anti-inflammatory cytokine adiponectin proinflammatory adipocytokines leptin resistin were performed nearly entire period therapy (up to 21 months), 9 patients ALL aged 2 7 years (median 4.3 y). Body mass index leukemic burden estimated same time points correlated levels. Nine healthy matched for age, sex, body used as...
Medulloblastoma (MB) is the most common malignant brain tumor in children. Heat shock proteins (HSPs) comprise a superfamily of that serve as molecular chaperones and are overexpressed wide range human cancers. The purpose present study was to investigate expression HSP27 (pSer(82)), (pSer(15)), HSP40, HSP60, HSP70, HSP90-α, Akt, phospho-Akt by multiplex bead array assay MBs. results HSP Akt were correlated with MB subtype; immunohistochemical Ki-67 index, bcl-2, p53; patients' prognosis.The...
The purpose of this study was to evaluate the quality life children and adolescents with any type cancer in all phases their treatment.Fifty-six newly diagnosed patients malignancy hospitalized a Pediatric Hematology-Oncology Unit Athens were included study. Minneapolis-Manchester Quality Life Instrument used for data collection from July 2010 December 2012. assessment adolescents' who under treatment performed three different stages treatment.The results showed that did not change notably...
Epidemiologic studies have indicated a relationship between serum lipids and cancer, it is possible that lipid abnormalities are involved in the mechanism of oncogenesis. This study was performed to investigate alterations patients with acute lymphoblastic leukemia (ALL) at diagnosis during remission disease. Plasma lipoproteins were measured diagnosis, prior administration induction treatment, every 2 months for first 12 maintenance phase chemotherapy 64 ALL. Nearly all demonstrated...