A5044926681- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Immunotherapy and Immune Responses
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- CNS Lymphoma Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Intraocular Surgery and Lenses
- Cancer-related Molecular Pathways
- Ocular Infections and Treatments
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Corneal surgery and disorders
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Glioma Diagnosis and Treatment
- Ear and Head Tumors
- Vascular Tumors and Angiosarcomas
- Simulation-Based Education in Healthcare
Université Paris Cité
2015-2025
Institut Curie
2018-2025
Centre de Recherche des Cordeliers
2020-2024
Inserm
2014-2024
Université Paris Sciences et Lettres
2018-2022
Sorbonne Université
2013-2021
Fondation Asile des Aveugles
2015-2020
University of Lausanne
2014-2020
Délégation Paris 5
2015-2020
Sorbonne Paris Cité
2018-2020
Purpose: To evaluate the influence of clinical and multimodal imaging parameters on duration acute central serous chorioretinopathy (CSCR) episodes. Methods: Consecutive patients with first, treatment-naïve episodes presenting within 20 days symptoms onset were prospectively included. They reevaluated 15 to later, followed by monthly evaluation for 6 months. Subfoveal choroidal thickness (SFCT), fluorescein leakage intensity angiography, elevation retinal pigment epithelium (RPE) lesions at...
Purpose: To evaluate the efficacy and safety of oral mineralocorticoid-receptor antagonist (MRa) therapy in three clinical presentations nonresolving central serous chorioretinopathy (CSCR) with chronic epitheliopathy. Methods: Retrospective case series consecutive patients CSCR treated eplerenone or spironolactone. Treatment criteria were: persistent subretinal fluid (SRF) lasting longer than 4 months; recurrent SRF 2 (SRF ≥ months) fundus autofluorescence gravitational tracks. Outcomes at...
Abstract Retinoblastoma is the most frequent intraocular malignancy in children, originating from a maturing cone precursor developing retina. Little known on molecular basis underlying biological and clinical behavior of this cancer. Here, using multi-omics data, we demonstrate existence two retinoblastoma subtypes. Subtype 1, earlier onset, includes heritable forms. It harbors few genetic alterations other than initiating RB1 inactivation corresponds to differentiated tumors expressing...
To describe recurrence patterns and investigate candidate risk factors for recurrences of central serous chorioretinopathy.In 46 patients with acute chorioretinopathy follow-up >12 months after first episode resolution, parameters influencing were retrospectively evaluated using a frailty Cox proportional hazard survival model. Covariates included baseline systemic findings: age, gender, corticosteroid use, stress, shift work, sleep disorder, depression, allergy, cardiovascular risk; optical...
Purpose: To determine the prevalence, clinical characteristics and nature of subfoveal nodules in Coats' disease associated impact on long-term visual outcome. Methods: Consecutive cases with foveal exudation were retrospectively reviewed. The presence a nodule or macular fibrosis was recorded. Clinical characteristics, retinal imaging, outcome analyzed by comparative analysis. histopathological description an enucleated eye performed. Results: Among 40 patients presenting unilateral Stage...
Purpose . “En face” is an emerging imaging technique derived from spectral domain optical coherence tomography (OCT). It produces frontal sections of retinal layers, also called “C-scan OCT.” Outer tubulations (ORTs) in age-related macular degeneration (AMD) are a recent finding evidenced by spectral-domain OCT. The aim this study to characterize the morphology ORT according form AMD, using “en-face” Methods OCT was prospectively performed 26 consecutive eyes with AMD that had ORT. Results...
To report the discordance in central serous chorioretinopathy (CSCR) classification among practising retina specialists.The study conducted was a multicentre survey. Multimodal retinal images along with relevant clinical details of 100 cases diagnosed as CSCR (from six centres) were circulated specialists across globe. The image sets included colour fundus photographs, autofluorescence images, optical coherence tomography b-scans, fluorescein and indocyanine green angiography fellow eyes....
To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, cavitations, signs deeper retinal vascular invasion.Retrospective review performed in a community-based referral center. The eyes were scanned using split-spectrum amplitude-decorrelation techniques to derive flow information. These data extracted used create images the vasculature with integrated...
To investigate choriocapillaris flow signal void distribution on optical coherence tomography (OCT) angiography in central serous chorioretinopathy (CSCR) and its correlation to choroidal vessel morphology.Fifty-three CSCR eyes (48 patients) 34 healthy control were included, retrospectively. Exclusion criteria refractive error >2D, previous laser or photodynamic therapy, low-quality OCT angiography, excessive shadowing artifacts. Choriocapillaris scans processed by local-threshold...
Uveal melanoma (UM) arises from malignant transformation of melanocytes in the uveal tract eye. This rare tumor has a poor outcome with frequent chemo-resistant liver metastases. BAP1 is only known predisposing gene for UM. UMs are generally characterized by low mutation burden, but some display high level CpG>TpG mutations associated MBD4 inactivation. Here, we explored incidence germline variants consecutive series 1093 primary UM case patients and 192 tumors monosomy 3 (M3).We performed...
Uveal melanoma (UM) is the most common cancer of eye. The loss chromosome 3 (M3) associated with a high risk metastases. M3 tumors are more infiltrated by T-lymphocytes than low-risk disomic-3 (D3) tumors, contrasting other tumor types in which T cell infiltration correlates better prognosis. Whether these cells represent an antitumor response and how would be primed eye both unknown. Herein, we characterized infiltrating primary UMs. CD8+ Treg were abundant D3 tumors. CD39+PD-1+CD8+...
Abstract Rhabdoid tumours (RT) are an aggressive malignancy affecting <2‐year‐old infants, characterised by biallelic loss‐of‐function alterations in SWI/SNF‐related BAF chromatin remodelling complex subunit B1 ( SMARCB1 ) nearly all cases. Germline found ~30% of patients and define the RT Predisposition Syndrome type 1 (RTPS1). Uveal melanoma (UVM), most common primary intraocular cancer adults, does not harbour alterations. We report two cases a previously undescribed that shared some...
Introduction: To report two cases of primary retinal ependymoma occurring in adults, both enucleated following initial suspicion uveal melanoma. Uveal melanoma is the most frequent tumor eye adults but other rare benign intraocular tumors such as leiomyoma, adenoma or ependymomas may also occur. diagnose them properly critical to adapt patient’s management, prognosis and follow-up. Ependymomas are exquisitely glial arising from retina, with only three reported yet. Primary clinical diagnosis...
To analyze microvascular and structural changes in radiation maculopathy their influence on visual acuity (VA), using optical coherence tomography (OCT) OCT angiography (OCTA).This was a retrospective analysis of consecutive patients with maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged fluorescein angiography, OCT, OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area,...