A5088103291- Bladder and Urothelial Cancer Treatments
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Urinary and Genital Oncology Studies
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- Ocular Oncology and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Venomous Animal Envenomation and Studies
- Breast Cancer Treatment Studies
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
Centre National de la Recherche Scientifique
2016-2025
Institut Curie
2016-2025
Université Paris Sciences et Lettres
2015-2025
La Ligue Contre le Cancer
2015-2023
Université Paris Cité
2018-2023
Sorbonne Université
2018-2023
Translational Research in Oncology
2023
Centre de Gestion Scientifique
2013-2023
Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
2010-2023
Zhongnan Hospital of Wuhan University
2022
Abstract Motivation: Genomic DNA regions are frequently lost or gained during tumor progression. Array Comparative Hybridization (array CGH) technology makes it possible to assess these changes in cancers, by comparison with a normal reference. The identification of systematically deleted amplified genomic set tumors enables biologists identify genes involved cancer progression because suppressor thought be located and oncogenes, regions. CGH profiles should also improve the classification...
Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors with poor outcome. Molecular stratification MIBC may identify clinically relevant tumor subgroups and help to provide effective targeted therapies. From seven series large-scale transcriptomic data (383 tumors), we identified an subgroup accounting for 23.5% MIBC, associated shorter survival displaying basal-like phenotype, as shown by the expression epithelial basal cell markers. Basal-like presented...
The advent of Omics technologies has been key to the molecular subclassification urothelial bladder cancer. Several groups have used different strategies this aim, with partially overlapping findings. meeting at Spanish National Cancer Research Center-CNIO was held discuss such classifications and reach consensus where appropriate. After updated presentations on work performed by teams attending meeting, a reached regarding existence group Basal-Squamous-like tumors - designated BASQ...
Extracting relevant information from large-scale data offers unprecedented opportunities in cancerology. We applied independent component analysis (ICA) to bladder cancer transcriptome sets and interpreted the components using gene enrichment tumor-associated molecular, clinicopathological, processing information. identified associated with biological processes of tumor cells or microenvironment, other revealed technical biases. Applying ICA nine types cancer-shared bladder-cancer-specific...
To evaluate variant histologies (VHs) for disease-specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC).We analysed a multi-institutional cohort of 1082 treated upfront RC cT1-4aN0M0 BCa at eight centres. Univariable and multivariable Cox' regression analyses were used to assess the effect different VHs on DSS overall three stage-based analyses. The stages defined as 'organ-confined' (≤pT2N0), 'locally advanced' (pT3-4N0)...
Fibroblast growth factor receptor 3 (FGFR3) mutations were recently found at a high frequency in well-differentiated urothelial cell carcinoma (UCC). We investigated the relationship between FGFR3 status and three molecular markers (MIB-1, P53, P27kip1) associated with worse prognosis determined reproducibility of pathologic grade variables.In this multicenter study, we included 286 patients primary (first diagnosis) UCC. The histologic slides reviewed. was examined by polymerase chain...
This study assessed the human epidermal growth factor receptor-2 (HER2) protein expression and its relationship with gene amplification in invasive bladder carcinoma, using same criteria than for breast cancer.In 1005 patients, paraffin-embedded tissues of transurethral resection or cystectomy were evaluated by immunohistochemistry (IHC), antibodies against HER2. All samples a 2+ 3+ HER2 overexpression FISH.HER2 was observed 93 (9.2%) tumors (2+: 42 3+: 51 tumors). Using FISH, all had...
Abstract Purpose: Clinically useful molecular markers predicting the clinical course of patients diagnosed with non–muscle-invasive bladder cancer are needed to improve treatment outcome. Here, we validated four previously reported gene expression signatures for diagnosis disease stage and carcinoma in situ (CIS) recurrence progression. Experimental Design: We analyzed tumors from 404 hospitals Denmark, Sweden, England, Spain, France using custom microarrays. Molecular classifications were...
Specific germline activating point mutations in the gene encoding tyrosine kinase receptor FGFR3 (fibroblast growth factor 3) result autosomal dominant human skeletal dysplasias. The identification multiple myeloma and two epithelial cancers—bladder cervical carcinomas—of somatic identical to germinal found dysplasias, together with functional studies, have suggested an oncogenic role for this receptor. Although acanthosis nigricans, a benign skin tumor, has been some syndromes associated of...
The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected signalling pathways involved in diverse cellular processes, such as cell cycle, survival, apoptosis and differentiation. Although several studies reported the involvement these cascades cancer deregulations, precise mechanisms underlying their influence on balance between proliferation death (cell fate decision) pathological circumstances remain elusive. Based an extensive analysis published data, we have...
To gain insight into genomic and transcriptomic subtypes of ductal carcinomas in situ the breast (DCIS).We did a combined phenotypic analysis series 57 DCIS integrated with gene expression profile for 26 cases.Thirty-two exhibited luminal phenotype; 21 were ERBB2 positive, 4 ERBB2/estrogen receptor (ER) negative 1 harboring bona fide basal-like phenotype. Based on CGH analysis, types identified this 1q gain/16q loss combination observed 3 DCIS, mixed amplifier pattern including all ERBB2, 12...
Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are often observed in cancer, where their understanding may provide new insights into etiology and clinical management. In this study, we combined statistical analyses computational modeling to explain patterns of alterations seen 178 patients with bladder tumors (either muscle-invasive non-muscle-invasive). A analysis on frequently altered genes identified pair associations, including exclusivity....
Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous inactivation suppressor RB1 VCN-01 an oncolytic adenovirus designed to replicate selectively in cells with high abundance free E2F-1, consequence dysfunctional pathway. Thus, we reasoned that could provide targeted therapeutic activity against even chemoresistant retinoblastoma. In vitro, effectively killed patient-derived retinoblastoma models. mice, intravitreous administration xenografts induced necrosis,...
Although immune checkpoint inhibitors have shown improvement in survival comparison to chemotherapy urothelial bladder cancer, many patients still fail respond these treatments and actual efforts are made identify predictive factors of response immunotherapy. Understanding the tumor-intrinsic molecular basis, like oncogenic pathways conditioning presence or absence tumor-infiltrating T cells (TILs), should provide a new rationale for improved anti-tumor therapies.In this study, we found that...