A5051502783- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Neurofibromatosis and Schwannoma Cases
- Research on Leishmaniasis Studies
- interferon and immune responses
- Sarcoma Diagnosis and Treatment
- Trypanosoma species research and implications
- Adrenal and Paraganglionic Tumors
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- Genetics, Bioinformatics, and Biomedical Research
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
Institut Curie
2015-2024
Inserm
2015-2024
Immunité et Cancer
2023-2024
Université Paris Sciences et Lettres
2015-2024
Centre National de la Recherche Scientifique
2014-2020
Marie Curie
2018-2019
Sorbonne Université
2018-2019
Institut d’Hématologie et d’Oncologie Pédiatrique
2015
Monash Institute of Medical Research
2014
Monash University
2014
Dendritic cells (DCs) are antigen-presenting controlling T cell activation. In humans, the diversity, ontogeny, and functional capabilities of DC subsets not fully understood. Here, we identified circulating CD88−CD1c+CD163+ DCs (called DC3s) as immediate precursors inflammatory CD88−CD14+CD1c+CD163+FcεRI+ DCs. DC3s develop via a specific pathway activated by GM-CSF, independent cDC-restricted (CDP) monocyte-restricted (cMoP) progenitors. Like classical but unlike monocytes, drove activation...
Abstract Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated local immunosuppression, which can be partly mediated regulatory T (Tregs). Here, we study Tregs from matched tumor-invaded non-invaded TDLNs, tumors. We observe that Treg frequencies increase nodal invasion, express higher levels of co-inhibitory/stimulatory receptors than effector cells. Also, while show conserved suppressive function TDLN tumor,...
The tumor genomic copy number profile is of prognostic significance in neuroblastoma patients. We have studied the cell-free DNA (cfDNA) and compared this with primary arrayCGH (aCGH) at diagnosis.In 70 patients, cfDNA profiling was performed using OncoScan platform. profiles were classified according to overall pattern, including numerical chromosome alterations (NCA), segmental (SCA), MYCN amplification (MNA).Interpretable dynamic obtained 66 52 cases, respectively. An identical between...
We aimed to determine the proportion of individuals in our schwannomatosis cohort whose disease is associated with an LZTR1 mutation.We used exome sequencing, Sanger and copy number analysis screen 65 unrelated who were negative for a germline NF2 or SMARCB1 mutation. also screened samples from 39 patients unilateral vestibular schwannoma (UVS), plus at least one other schwannoma, but did not have identifiable mosaic identified mutations 6 16 (37.5%) had affected relative, 11 49 (22%)...
Abstract Rhabdoid tumours (RTs) are highly aggressive of infancy, frequently localized in the central nervous system (CNS) where they termed atypical teratoid/rhabdoid (AT/RTs) and characterized by bi-allelic inactivation SMARCB1 tumour suppressor gene. In this study, temporal control tamoxifen injection Smarcb1 flox/flox ;Rosa26-Cre ERT2 mice, we explore phenotypes associated with at different developmental stages. Injection before E6, birth or 2 months age recapitulates previously...
Although immune checkpoint inhibitors have shown improvement in survival comparison to chemotherapy urothelial bladder cancer, many patients still fail respond these treatments and actual efforts are made identify predictive factors of response immunotherapy. Understanding the tumor-intrinsic molecular basis, like oncogenic pathways conditioning presence or absence tumor-infiltrating T cells (TILs), should provide a new rationale for improved anti-tumor therapies.In this study, we found that...
Abstract Regulatory T cells (Tregs) are plastic playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to microenvironment where they reside; as consequence, their molecular and functional profiles differ among tissues pathologies. In tumors, features acquired by remains poorly characterized. Here, we observe that human tumor-infiltrating selectively overexpress CD74, MHC class II invariant chain. CD74 has been previously described regulator antigen-presenting...
Background Rhabdomyosarcoma (RMS) occasionally occurs in a context of predisposition syndrome. The most common syndromes include germline TP53 mutations and constitutive alterations RAS pathway activation, such as Costello syndrome, Noonan syndrome neurofibromatosis type 1. We report national retrospective series 16 RMS occurring 1 (NF1) patients during childhood, within 20-year period. Results mean age at diagnosis the cancer was 2.5 years. All were embryonal subtype. Most tumours developed...
The accumulation of tumor-associated macrophages (TAMs) is correlated with poor clinical outcome, but the mechanisms governing their differentiation from circulating monocytes remain unclear in humans.Using multicolor flow cytometry, we evaluated TAMs phenotype 93 breast cancer (BC) patients. Furthermore, healthy donors were cultured presence supernatants dilacerated primary tumors to investigate into (MΦ) vitro. Additionally, used transcriptomic analysis evaluate BC patients' blood...
Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation states functions. How tissue-specific cues orchestrate DC diversification remains elusive. Here, we show the small intestine included two pools cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) CD103
BACKGROUND: To describe therapeutic approaches in children with atypical Teratoid Rhabdoid Tumours (ATRT) France.METHODS: Observational study including all less than 18 years old diagnosed ATRT France between 2009 and 2011.RESULTS: Forty seven were included this retrospective study.Six patients received no curative treatment while forty-one had a project.Median age was 1.5 (range 0-16).The disease disseminated 10 patients.Surgical resection complete 21 cases.Chemotherapy administered 41...
Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and breast cancer. In particular, epigenetic alterations at different members of the pathway have been identified among triple-negative, basal-like cancers. Previously, we developed mouse model for metaplastic adenocarcinoma, subtype triple-negative cancer, by targeting hypomorphic mutations endogenous Apc gene (Apc1572T/+). Here, employing CD24 CD29 surface antigens, subpopulation cancer cells (MaCSCs) from...
The IL-17 family contributes to host defense against many intracellular pathogens by mechanisms that are not fully understood. CD8+ T lymphocytes key elements microbes, and their survival ability mount cytotoxic responses orchestrated several cytokines. Here, we demonstrated IL-17RA-signaling cytokines sustain pathogen-specific cell immunity. absence of IL-17RA IL-17A/F during Trypanosoma cruzi infection resulted in increased tissue parasitism reduced frequency parasite-specific cells....
Senescent T cells have been described during aging, chronic infections, and cancer; however, a comprehensive study of the phenotype, function, transcriptional program this cell population in breast cancer (BC) patients is missing. Compared to healthy donors (HDs), BC exhibit an accumulation KLRG-1+CD57+ CD4+ CD8+ peripheral blood. These infiltrate tumors tumor-draining lymph nodes. from HDs features senescence, despite their inhibitory receptor expression, they produce more effector...
Summary Triatoma infestans is the main vector of Chagas disease and target control programmes in Southern Cone countries. So far Bolivia only country where true T. wild foci are documented. The dispersal ability for was studied at microgeographical scale Bolivian Andes, to assess possibility populations actively recolonize insecticide‐treated villages. Nine microsatellite loci were used detect extent gene flow between neighbouring collecting sites. detection restricted close but distinct...
Medulloblastomas (MB) are classified in four subgroups: the well defined WNT and Sonic Hedgehog (SHH) subgroups, less groups 3 4. They occasionally occur context of a cancer predisposition syndrome. While germline APC mutations predispose to MB, SUFU, PTCH1, TP53 SHH tumors. We report on child with Rubinstein–Taybi syndrome (RTS) due deletion CREBBP, who developed MB. Biological profilings demonstrate that this tumor belongs group 3. RTS may therefore be first identified for non-WNT/non-SHH...
Rhabdoid tumors (RTs) are aggressive of early childhood characterized by SMARCB1 inactivation. Their poor prognosis highlights an urgent need to develop new therapies. Here, we performed a high-throughput screening approved drugs and identified broad inhibitors tyrosine kinase receptors (RTKs), including pazopanib, the potassium channel inhibitor clofilium tosylate (CfT), as SMARCB1-dependent candidates. Pazopanib targets were PDGFRα/β FGFR2, which most highly expressed RTKs in set primary...
Abstract Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics and environmental exposures. Little evidence exists regarding immune infiltration response to treatment in sBBCs. Here we show that impact of subtype on levels tumor infiltrating lymphocytes (TILs, n = 277) pathologic complete (pCR) rates ( 140) differed according concordant or discordant contralateral tumor: luminal tumors with a had higher TIL pCR than those tumor....