A5103845501- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Cellular transport and secretion
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- NF-κB Signaling Pathways
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
- interferon and immune responses
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Complement system in diseases
Université Paris Sciences et Lettres
2021-2024
Immunité et Cancer
2022-2024
Inserm
2019-2024
Institut Curie
2019-2024
University of Chile
2024
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These can adapt to such deformation events using dedicated shape-sensing pathways. However, how sensing affects immune function is mostly unknown. Here, we identify a mechanism increases expression chemokine receptor CCR7 and guides dendritic migration from peripheral tissues lymph nodes at steady state. This relies on lipid...
Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation states functions. How tissue-specific cues orchestrate DC diversification remains elusive. Here, we show the small intestine included two pools cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) CD103
Abstract Motile cells such as immune and cancer experience large deformation events that result from the physical constraints they encounter while migrating within tissues or circulating between organs. It has become increasingly clear these can survive adapt to changes in cell shape using dedicated sensing pathways. However, how impacts their function fate remains largely unknown. Here we identify a mechanism couples motility expression of CCR7, chemokine receptor guides lymph nodes. We...
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN FYVE domain-containing protein 3 (RUFY3) exists as alternative isoforms distinguishable by presence of a C-terminal domain their affinity phosphatidylinositol 3-phosphate on endosomal membranes. The domain-bearing isoform (iRUFY3) is preferentially expressed primary immune cells up-regulated upon activation...
ABSTRACT Myeloid cells use intracellular actin networks for key cellular processes, including cell migration and chemotaxis, phagocytosis or macropinocytosis, as well immune synapse formation. However, whether these play any role in the development and/or survival of myeloid tissues remains open. Here, we found that Arp2/3 complex, which is responsible nucleation branched networks, needed vivo maintenance epidermal Langerhans (LCs) throughout life. Mice harboring a genetic deletion Arpc4...
Abstract Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN FYVE domain-containing protein 3 exists as alternative isoforms distinguishable by presence of a C-terminal domain their affinity PtdIns(3)P on endosomal membranes. The domain-bearing isoform (iRUFY3) is preferentially expressed immune cells up-regulated upon activation cytokines. iRUFY3 ARL8b+/LAMP1+...
Dendritic cells (DCs) patrol tissues and migrate to lymph nodes for presentation of collected antigens T cells. This process is needed initiate immune responses against infectious agents as well maintain tolerance tissue self-antigens at steady state. In both cases, DC migration requires the upregulation chemokine receptor CCR7. It well-known that upon infection, CCR7 expression induced by microbial inflammatory components released within environment. However, environmental signals trigger...