A5072846757- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Olfactory and Sensory Function Studies
- Ion Channels and Receptors
- Viral-associated cancers and disorders
- Calpain Protease Function and Regulation
- Histiocytic Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Immunotherapy and Immune Responses
- RNA regulation and disease
Saarland University
2021-2025
Abstract Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release either acetylcholine, leukotriene C4 and/or interleukin-25 depending on activating stimuli, cell-dependent mechanisms underlying recruitment and activation are incompletely understood. Here we show that Pseudomonas aeruginosa infection activates mouse cells, which ATP via pannexin 1 channels. Taste signaling through Trpm5 channel is essential for...
ABSTRACT The barrier-forming, self-renewing mammalian epidermis comprises keratinocytes, pigment-producing melanocytes and resident immune cells as first-line host defense. In murine tail skin, interfollicular patterns into pigmented ‘scale’ hypopigmented ‘interscale’ epidermis. Why how mature accumulate in scale is unresolved. Here, we delineate a cellular hierarchy among epidermal cell types that determines skin patterning. Already during postnatal development, co-segregate with newly...
ABSTRACT Dysfunctions in melanocytes can lead to pigmentation disorders, such as albinism, or contribute the development of melanoma, most aggressive form skin cancer. Epidermal typically interact with collagen IV-rich basement membrane, but upon injury pathological conditions, they encounter environments rich I fibronectin. While alterations ECM composition and stiffness are known impact cell behavior, specific roles each these cues for melanocyte functions remain unclear. To explore...
ABSTRACT Myeloid cells use intracellular actin networks for key cellular processes, including cell migration and chemotaxis, phagocytosis or macropinocytosis, as well immune synapse formation. However, whether these play any role in the development and/or survival of myeloid tissues remains open. Here, we found that Arp2/3 complex, which is responsible nucleation branched networks, needed vivo maintenance epidermal Langerhans (LCs) throughout life. Mice harboring a genetic deletion Arpc4...
ABSTRACT The barrier-forming, self-renewing mammalian epidermis comprises keratinocytes, pigment- producing melanocytes, and resident immune cells as first-line host defense. In murine tail skin, interfollicular patterns into pigmented ′scale′ hypopigmented ′interscale′ epidermis. Why how mature melanocytes accumulate in scale is unresolved. Here, we delineate a cellular hierarchy among epidermal cell types that determines skin patterning. Already during postnatal development, co-segregate...