A5044508763- Immune cells in cancer
- Immunotherapy and Immune Responses
- interferon and immune responses
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Nuclear Structure and Function
- Cancer Research and Treatments
- Viral Infections and Vectors
- Clusterin in disease pathology
- Histiocytic Disorders and Treatments
- CRISPR and Genetic Engineering
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related Molecular Pathways
- Chemokine receptors and signaling
- Advanced biosensing and bioanalysis techniques
- Eicosanoids and Hypertension Pharmacology
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
- Insect Pest Control Strategies
- Cancer Immunotherapy and Biomarkers
International Centre for Genetic Engineering and Biotechnology
2020-2024
Veneto Institute of Molecular Medicine
2021
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These can adapt to such deformation events using dedicated shape-sensing pathways. However, how sensing affects immune function is mostly unknown. Here, we identify a mechanism increases expression chemokine receptor CCR7 and guides dendritic migration from peripheral tissues lymph nodes at steady state. This relies on lipid...
Receptors controlling the cross-presentation of tumor antigens by macrophage subsets in cancer tissues are poorly explored. Here, we show that TIM4
Lung tumor-infiltrating neutrophils are known to support growth and dissemination of cancer cells suppress T cell responses. However, the precise impact tissue on programming differentiation anticancer CD8 in vivo remains poorly understood. Here, we identified cell-autonomous secretion CXCL5 as sufficient drive infiltration mature, protumorigenic a mouse model non-small lung (NSCLC). Consistently, transcripts correlate with neutrophil density poor prognosis large human adenocarcinoma...
Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance intercellular contacts between cDC1 CD8 T in cancer tissues is important to determine the outcome response. However, molecular determinants controlling stability cDC1–CD8 interactions during progression remain poorly investigated. Here, we generated a genetic model non-small cell lung crossed fluorescent reporter (KP-XCR1venus) allow detection cDC1-CD8T clusters...
Dysregulated sensing of self-nucleic acid is a leading cause autoimmunity in multifactorial and monogenic diseases. Mutations Wiskott-Aldrich syndrome protein (WASp), key regulator cytoskeletal dynamics immune cells, autoimmune manifestations increased production type I IFNs by innate cells. Here we show that complexes self-DNA autoantibodies (DNA-ICs) contribute to elevated IFN levels via activation the cGAS/STING pathway cytosolic sensing. Mechanistically, lack endosomal F-actin nucleation...
ABSTRACT Myeloid cells use intracellular actin networks for key cellular processes, including cell migration and chemotaxis, phagocytosis or macropinocytosis, as well immune synapse formation. However, whether these play any role in the development and/or survival of myeloid tissues remains open. Here, we found that Arp2/3 complex, which is responsible nucleation branched networks, needed vivo maintenance epidermal Langerhans (LCs) throughout life. Mice harboring a genetic deletion Arpc4...
Abstract Motile cells such as immune and cancer experience large deformation events that result from the physical constraints they encounter while migrating within tissues or circulating between organs. It has become increasingly clear these can survive adapt to changes in cell shape using dedicated sensing pathways. However, how impacts their function fate remains largely unknown. Here we identify a mechanism couples motility expression of CCR7, chemokine receptor guides lymph nodes. We...
Cross-presentation of tumor antigens by subsets macrophages at different stages along progression may have divergent impacts on anti-tumoral immune responses. Here we show that TIM4+ large peritoneal (LPM) avidly capture cells and cross-present tumor-associated early infiltration ovarian cancer cells. The phosphatidylserine (PS) receptor TIM4 promotes maximal uptake triggers inflammatory metabolic gene programs in combination with cytoskeletal remodeling upregulation transcriptional...
Abstract Mutations in the immune-specific actin regulator WASp induce a proinflammatory state myeloid cells, whose underlying causes remain poorly defined. Here, we applied microfabricated tools that mimic tissue mechanical forces to explore role of connecting mechano-sensing activation inflammatory responses macrophages. We show WASp-deficient macrophages carry nuclear structure alterations and undergo increased blebbing rupture when exposed confinement. High-resolution imaging indicates...