A5031004880- Nuclear Structure and Function
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Erythrocyte Function and Pathophysiology
- Retinoids in leukemia and cellular processes
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- PARP inhibition in cancer therapy
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- thermodynamics and calorimetric analyses
- Congenital limb and hand anomalies
- Microtubule and mitosis dynamics
- Breast Implant and Reconstruction
- interferon and immune responses
- Immune Response and Inflammation
- Automotive and Human Injury Biomechanics
- RNA regulation and disease
- Cancer Genomics and Diagnostics
Institut Pierre-Gilles de Gennes pour la Microfluidique
2021-2025
Institut Curie
2021-2025
Université Paris Sciences et Lettres
2021-2025
Centre National de la Recherche Scientifique
2021-2025
Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
2021
Sanofi (France)
2019
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These can adapt to such deformation events using dedicated shape-sensing pathways. However, how sensing affects immune function is mostly unknown. Here, we identify a mechanism increases expression chemokine receptor CCR7 and guides dendritic migration from peripheral tissues lymph nodes at steady state. This relies on lipid...
Mechanics has been a central focus of physical biology in the past decade. In comparison, how cells manage their size is less understood. Here, we show that parameter to both physics and physiology cell, its volume, depends on mechano-osmotic coupling. We found change volume depending rate at which they shape, when spontaneously spread or are externally deformed. Cells undergo slow deformation constant while fast leads loss. propose mechanosensitive pump leak model explain this phenomenon....
Abstract Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark many pathologies such as cancers, since causing affection epigenome and transcriptional reprogramming. Here, we demonstrate that loss-of-function mutation (LOF) major histone lysine methyltransferase SETDB1 possessing oncogenic activity lung cancer cells leads to broad changes overall architecture mechanical properties nucleus through genome-wide redistribution heterochromatin, which perturbs...
Errors during cell division lead to aneuploidy, which is associated with genomic instability and transformation. In response cells activate the tumour suppressor p53 elicit a surveillance mechanism that halts proliferation promotes senescence. The molecular sensors trigger this checkpoint are unclear. Here, using tunable system of chromosome mis-segregation, we show mitotic errors nuclear deformation, softening, lamin heterochromatin alterations, leading rapid p53/p21 activation upon exit in...
The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but role of nuclear envelope proteins in this process is incompletely understood. Inner transmembrane SUN1 and SUN2 connect lamins cytoskeleton participate DNA damage response (DDR). Increased levels or potently restrict HIV infection through an unresolved mechanism. Here, we find that antiviral activities are distinct. HIV-1 HIV-2 preferentially inhibited by SUN2, respectively. We identify inducers stimulate...
Abstract Motile cells such as immune and cancer experience large deformation events that result from the physical constraints they encounter while migrating within tissues or circulating between organs. It has become increasingly clear these can survive adapt to changes in cell shape using dedicated sensing pathways. However, how impacts their function fate remains largely unknown. Here we identify a mechanism couples motility expression of CCR7, chemokine receptor guides lymph nodes. We...
Abstract Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark many pathologies such as cancers, since causing affection epigenome and transcriptional reprogramming. Here, we demonstrate that loss-of-function mutation (LOF) major histone lysine methyltransferase SETDB1 possessing oncogenic activity lung cancer cells leads to broad changes overall architecture mechanical properties nucleus through genome-wide redistribution heterochromatin, which perturbs...
Metastatic breast cancer results in substantial morbidity and mortality for women afflicted with this disease. Approximately 80% of cancers express the estrogen receptor. The cell survival proliferation is driven by activation SAR439859 an effective endocrine therapy selectively effectively degrading A phase 1/2 study alone and/or combination palbociclib postmenopausal receptor positive advanced was initiated last year Sanofi.CRISPR/Cas9 a recent revolutionary technology efficient directed...
Abstract Metastatic breast cancer results in substantial morbidity and mortality for women afflicted with this disease. Approximately 80% of cancers express the estrogen receptor. The cell survival proliferation is driven by activation SAR439859 an effective endocrine therapy selectively effectively degrading A phase 1/2 study alone and/or combination palbociclib postmenopausal receptor positive advanced was initiated last year Sanofi. CRISPR/Cas9 a recent revolutionary technology efficient...
Dendritic cells (DCs) patrol tissues and migrate to lymph nodes for presentation of collected antigens T cells. This process is needed initiate immune responses against infectious agents as well maintain tolerance tissue self-antigens at steady state. In both cases, DC migration requires the upregulation chemokine receptor CCR7. It well-known that upon infection, CCR7 expression induced by microbial inflammatory components released within environment. However, environmental signals trigger...