A5036132330- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Cell Adhesion Molecules Research
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- Glycosylation and Glycoproteins Research
- Protein Kinase Regulation and GTPase Signaling
- Hippo pathway signaling and YAP/TAZ
- 3D Printing in Biomedical Research
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Caveolin-1 and cellular processes
- Nuclear Structure and Function
- Retinal Development and Disorders
- Antioxidant Activity and Oxidative Stress
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- PI3K/AKT/mTOR signaling in cancer
IFOM
2016-2025
University of Milan
2016-2025
European Institute of Oncology
2007-2025
Italian Association for Cancer Research
2006-2024
Molecular Oncology (United States)
2024
University of Parma
1993-2021
Mylan (Switzerland)
2018-2020
Milano University Press
2018-2020
Ripamonti
1999-2018
Ospedale San Paolo
2016-2018
PURPOSE: To determine the immunogenicity and antitumor activity of a vaccine consisting autologous, tumor-derived heat shock protein gp96-peptide complexes (HSPPC-96, Oncophage; Antigenics, Inc, Woburn, MA) in metastatic (American Joint Committee on Cancer stage IV) melanoma patients. PATIENTS AND METHODS: Sixty-four patients had surgical resection tissue required for production, 42 were able to receive vaccine, 39 assessable after one cycle vaccination (four weekly injections). In 21...
Actin polymerization-driven protrusion of the leading edge is a key element cell motility. The important actin nucleators formins and Arp2/3 complex are believed to have nonoverlapping functions in inducing filament bundles filopodia dendritic networks lamellipodia, respectively. We tested this idea by investigating role mDia2 formin leading-edge loss-of-function gain-of-function approaches. Unexpectedly, depletion short interfering RNA (siRNA) severely inhibited lamellipodia. Structural...
ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence activity at responds mechanical stress. Human associates with S phase prophase, both osmotic stress stretching relocalize membranes throughout cell cycle. The ATR-mediated response occurs within range of physiological forces, is reversible,...
Oxidative modification of low density lipoproteins (LDL) and their unrestricted scavenger receptor-dependent uptake is believed to account for cholesterol deposition in macrophage-derived foam cells. It has been suggested that vitamin E transported by LDL plays a critical role protecting against oxidation. We hypothesize the maintenance sufficiently high concentrations can be achieved reducing its chromanoxyl radicals, i.e., recycling. In this study we demonstrate that: i) radicals...
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. However, how the signal routed from PI3K to unclear. One possible candidate for function Rac-activating complex Eps8–Abi1–Sos-1, which possesses Rac-specific guanine nucleotide exchange factor (GEF) activity. Here, we show that Abi1 (also known as...