A5032851590- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Soybean genetics and cultivation
- SARS-CoV-2 detection and testing
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Lymphoma Diagnosis and Treatment
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Antibiotics Pharmacokinetics and Efficacy
- Soil Management and Crop Yield
- COVID-19 diagnosis using AI
- Liver Disease and Transplantation
- Natural Language Processing Techniques
University of Padua
2016-2025
Azienda Ospedaliera di Padova
2004-2024
Hospital for Tropical Diseases
2023
Weatherford College
2021
Leoni (Germany)
2021
Jackson and Tull (United States)
2020
George Mason University
2020
Carnegie Mellon University
2020
University of Rome Tor Vergata
2020
Santa Maria Nuova Hospital
2001-2019
Remdesivir demonstrated clinical benefit in a placebo-controlled trial patients with severe coronavirus disease 2019 (COVID-19), but its effect moderate is unknown.
In contrast to the established relation between overt cancer and subsequent venous thromboembolism, it is unclear whether symptomatic deep-vein thrombosis associated with a risk of malignant disease.
Although many studies have been conducted to identify the specific traits by which plant growth–promoting rhizobacteria (PGPR) promote growth, usually they were limited studying just one or two of these traits. We selected 116 isolates from bulk soil and rhizosphere soybean [ Glycine max (L.) Merr.] examined them for a wide array that might increase early growth in nonsterile (PGPR traits). A subsample 23 isolates, all but tested positive more PGPR traits, was further screened associated...
Repair of the endothelium after vascular injury is crucial for preserving endothelial integrity and preventing development disease. The underlying mechanisms cell repair are largely unknown. We sought to investigate whether microparticles (EMPs), released from apoptotic cells (ECs), influence EC repair.Systemic treatment mice with EMPs electric denudation accelerated reendothelialization in vivo. In vitro experiments revealed that EMP uptake ECs promotes migration proliferation, both...
PURPOSE: To determine the immunogenicity and antitumor activity of a vaccine consisting autologous, tumor-derived heat shock protein gp96-peptide complexes (HSPPC-96, Oncophage; Antigenics, Inc, Woburn, MA) in metastatic (American Joint Committee on Cancer stage IV) melanoma patients. PATIENTS AND METHODS: Sixty-four patients had surgical resection tissue required for production, 42 were able to receive vaccine, 39 assessable after one cycle vaccination (four weekly injections). In 21...
Since the outbreak of COVID-19 epidemic which in our region, Veneto (Italy), dates back to February, we were confronted with several challenges, but a constant aim keeping Stroke Unit COVID-free. For this reason, addition creating dedicated hot-spot as pre-triage just outside Emergency Department, together Neuroradiology obtained mobile CT unit that could be used by COVID-positive or COVID-suspected patients. Furthermore, thanks collaboration colleagues from different specialties (Infectious...
The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a relevant threat for humans worldwide. Abnormality in liver function tests (LFTs) been commonly observed patients with COVID-19, but there is controversy on its clinical significance. aim this study was to assess the prevalence, characteristics and impact abnormal LFTs hospitalized, non-critically ill COVID-19.In multicentre, retrospective study, we collected data about 565 inpatients COVID-19. Data were at admission every 7...
Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending single clinic. The aim this analysis GEPPO was to compare prevalence risk factors individual non-communicable diseases (NCD), multi-morbidity (MM) polypharmacy (PP) amongst HIV positive negative enrolment into cohort. This cross-sectional study conducted between...
Soybean is the main crop in Brazil, both scale and value. Nonetheless, beginning was very humble. a minor until 1960s, when it restricted to South Region (subtropical), from where expanded Midwest (tropical) 1980s. That possible thanks development of cultivars well adapted low latitude conditions Region. In Region, home Cerrado Biome, land plentiful affordable with flat topography, deep soils, drained easy handle. The challenge related soil fertility, originally acidic poor nutrients. role...
To improve our understanding of the natural history Zika virus (ZIKV) infection in humans, we described dynamics ZIKV RNA shedding different body fluids and antibody responses patients with acute infection. Twenty-nine adults travel-associated 1 case sexual transmission were enrolled followed up weekly testing blood, urine, saliva, semen samples testing. was detected plasma, saliva 57%, 93.1%, 69.2% participants, estimated median times to clearance 11.5 days (interquartile range [IQR] 6–24...
A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for clinical outcomes, and several studies investigated immune profiling of SARS-CoV-2 infected people properly direct management disease. Thus, lymphopenia, T-cell exhaustion, increased levels inflammatory mediators have been described in patients, particular severe cases
Abstract Because other coronaviruses enter the cells by binding to dipeptidyl‐peptidase‐4 (DPP‐4), it has been speculated that DPP‐4 inhibitors (DPP‐4is) may exert an activity against severe acute respiratory syndrome coronavirus 2. In absence of clinical trial results, we analysed epidemiological data support or discard such a hypothesis. We retrieved information on exposure DPP‐4is among patients with type 2 diabetes (T2D) hospitalized for COVID‐19 at outbreak hospital in Italy. As...
Background: Experience in real clinical practice with ceftazidime-avibactam for the treatment of serious infections due to gram−negative bacteria (GNB) other than carbapenem-resistant Enterobacterales (CRE) is very limited. Methods: We carried out a retrospective multicenter study patients hospitalized 13 Italian hospitals who received ≥72 h GNB CRE assess rates success, resistance development, and occurrence adverse events. Results: Ceftazidime-avibactam was used treat 41 CRE. Median age 62...
Abstract Objectives Thrombin generation (TG) with and without thrombomodulin (TM) was evaluated in COVID-19 patients different disease severity thromboprophylaxis regimen, order to understand the prothrombotic profile. Methods We enrolled consecutive confirmed diagnosis of admitted Medical Departments (MD) or Intensive Care Units (ICU), 54 healthy controls. Results Eighty-nine were included (mean age 60.4±16.1 years, 68.5% male); 33.7% ICU. Twenty-four (26.9%) before administration; 45...
A population pharmacokinetic analysis of dalbavancin was conducted in patients with different infection sites. Non-linear mixed effect modeling used for and covariate evaluation. Monte Carlo simulations assessed the probability target attainment (PTA) total concentration ≥ 8.04 mg/L over time (associated ≥90% optimal pharmacodynamic fAUC24h/MIC > 111.1 against S. aureus) associated a single or double dosage, one week apart, 1000 1500 mg classes renal function. Sixty-nine 289 concentrations...
Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) were recently approved for the early treatment of COVID-19, but real-life data on tolerability, safety, adverse events (AEs) are still scarce.We conducted a retrospective cohort study including all patients who prescribed MOL NIR at Infectious Diseases Unit Padua University Hospital, between January May 2022. Demographic, clinical, safety variables recorded.We included 909 patients, 48.3% males 95.2% vaccinated against SARS-CoV-2. The...
A large increase in multi-drug-resistant Acinetobacter baumannii, especially carbapenem-resistant strains, occurred during the first two years of COVID-19 pandemic, posing important challenges its treatment. Cefiderocol appeared to be a good option for treatment Carbapenem-resistant baumannii (CR-Ab), but date, guidelines and evidence available are conflicting.We retrospectively included group patients with CR-Ab infections (treated colistin- or cefiderocol-based regimens) at Padua...
Abstract Objectives Advancements in Artificial Intelligence(AI) have made platforms like ChatGPT increasingly relevant medicine. This study assesses ChatGPT’s utility addressing bacterial infection-related questions and antibiogram-based clinical cases. Methods involved a collaborative effort involving infectious disease (ID) specialists residents. A group of experts formulated six true/false, open-ended questions, cases with antibiograms for four types infections (endocarditis, pneumonia,...
The PRESTIGIO Registry was established in 2017 to collect clinical, virological and immunological monitoring data from people living with HIV (PLWH) documented four-class drug resistance (4DR). Key research purposes include the evaluation of residual susceptibility specific antiretrovirals validation treatment strategies this population.