A5102908561- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Chronic Lymphocytic Leukemia Research
- Poxvirus research and outbreaks
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- CNS Lymphoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Bacillus and Francisella bacterial research
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rabies epidemiology and control
- Pneumonia and Respiratory Infections
- Syphilis Diagnosis and Treatment
University Hospital Schleswig-Holstein
2006-2025
University of Lübeck
2006-2025
Infektionsmedizinisches Centrum Hamburg
2016-2025
Robert Koch Institute
2024
Kiel University
2006-2024
Hospital Ramos Mejía
2022
St. Josefs Hospital
2019
German Center for Infection Research
2019
Goethe University Frankfurt
2019
University Hospital Frankfurt
2019
Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of poorly defined.
Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients COVID-19 reveals symptoms and outcome this special population.Retrospective analysis anonymized data including age, gender, HIV-associated parameters, symptoms, outcome.Three out 32 documented outcomes died (9%). 91% recovered 76% have been classified as mild cases. All were antiretroviral treatment, them 22 tenofovir-containing regimen 4...
Objectives A prior T cell depletion induced by HIV infection may carry deleterious consequences in the current COVID‐19 pandemic. Clinical data on patients co‐infected with and SARS‐CoV‐2 are still scarce. Methods This multicentre cohort study evaluated risk factors for morbidity mortality of people living (PLWH), infected three countries different clinical settings. was clinically classified as to be mild‐to‐moderate or severe. Results Of 175 patients, 49 (28%) had severe 7 (4%) died....
Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly Africa, suggested a higher risk for severe MPXV cases in people living with HIV.This was retrospective study all confirmed observed the participating centres since 19 2022. We conducted chart review to evaluate clinical characteristics, comorbidities, coinfections, including HIV, viral hepatitis, sexually transmitted (STIs).By 30 June total 546 were...
Abstract Purpose To evaluate the association between percentages of older age groups among confirmed SARS-CoV-2 infections and country-specific case fatality rate (CFR). Methods This ecological study analyzed data from 20 most severely affected European countries, USA Canada, in which national health authorities provided on distribution gender cases deaths. Results The proportion individuals than 70 years differed markedly ranging 4.9 to 40.4%. There was a strong linear 75 CFRs ( R 2 = 0.803...
Objective: To evaluate the impact of different antiretroviral therapies on prognosis AIDS patients affected by progressive multifocal leukoencephalopathy (PML). Methods: A retrospective analysis all HIV-infected admitted to hospital between 1988 and 1996 found 29 (25 men) with histologically or PCR- confirmed PML. Their mean age was 39.3 years. The median CD4 cell count 40 × 106/l (mean, 106 106/l). Six had counts > 200 106/l. Fourteen never received stopped therapy following diagnosis...
To evaluate the impact of immune recovery induced by highly active antiretroviral therapy (HAART) on survival AIDS patients with primary central nervous system lymphoma (PCNSL).In a multicentric retrospective analysis, 29 HIV-infected histologically confirmed PCNSL were identified. median survival, Kaplan-Meier statistics used. explore effects different variables Weibull accelerated failure time regression analysis was performed.Median age at manifestation 39.1 years and CD4 cell count 11 x...
AIDS-related lymphoma contributes to significant morbidity and mortality among human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART). We assessed the predictive role of cumulative HIV viremia other risk factors in development non-Hodgkin lymphoma.Data from Clinical Surveillance Disease (ClinSurv) study, an ongoing, observational, open cohort study HIV-infected different urban areas Germany, were analyzed using a Cox proportional hazards...
Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in CYP2B6 gene are associated with pharmacokinetics. Since constitutive androstane receptor (CAR) pregnane X (PXR) correlate liver, a CAR polymorphism (rs2307424) smoking plasma concentrations, we investigated their association early (<3 months) discontinuation therapy. Three hundred seventy-three patients initiating therapy an efavirenz-based regimen were included...
Objectives Antiretroviral therapy reduces mortality and morbidity in HIV ‐infected individuals most markedly when initiated early, before advanced immunodeficiency has developed. Late presentation for diagnosis care remains a significant challenge. To guide public health interventions effectively it is crucial to describe the factors associated with late presentation. Methods Case surveillance data all newly diagnosed infection G ermany years 2001–2010 1999–2010 from erman C linical S...
In the Strategic Timing of Antiretroviral Treatment (START) study, immediate combination antiretroviral therapy (cART) initiation reduced cancer risk by 64%. We hypothesized that reduction was higher for infection-related and determined differences in CD4 cell counts human immunodeficiency virus (HIV) RNA between study arms. Incident malignancies START were categorized into infection-unrelated cancer. used Cox models to assess factors associated with both categories. sequential adjustment...
Background: AIDS-related lymphoma (ARL) remains a frequent complication of HIV infection. We analyzed the outcome patients with ARL respect to use and efficacy highly active antiretroviral therapy (HAART) potential prognostic factors. Methods: This multicenter cohort study included systemic diagnosed between 1990–2001. evaluated overall survival effects several variables on using Kaplan–Meier method extended Cox proportional hazards model. Response HAART was used as time-dependent variable...
Hodgkin's disease (HD) is the most common non-acquired immunodeficiency syndrome (AIDS)-defining malignancy in human virus (HIV)-infected patients. We analysed outcome of patients with HIV-associated HD (HIV-HD) respect to use and efficacy highly active antiretroviral therapy (HAART) other prognostic factors. To evaluate effects several variables on overall survival (OS), Kaplan-Meier statistics extended Cox regression analysis were performed. Response HAART was used as a time-dependent...
Out of 302 AIDS-related lymphoma (ARL) patients enrolled in the German ARL cohort study, 18 had plasmablastic (PBL). Twelve out (67%) have died with a median survival 4 months (range 0-11 months). In univariate analysis, an intermediate or high international prognostic index score was associated significantly lower overall and progression-free survival. The predominant cause death progressive (67%). Our data indicate that outcome PBL is still very poor.
Abstract Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic is still scarce. This case series of 33 PLWH patients COVID-19 reveals symptoms and outcome this special population. Three out 32 documented died (9%). However, 91% recovered 76% have been classified as mild cases, indicating that there no excess morbidity mortality among symptomatic COVID-19. All were antiretroviral treatment, them 22 tenofovir-containing regimen, 4 protease inhibitor...
A case of biopsy verified progressive multifocal leucoencephalopathy (PML) in an HIV patient is presented. Imaging and histological examination confirmed remarkable inflammatory activity accompanied by unusually benign clinical course despite no clear evidence immune reconstitution after the start antiretroviral treatment. This not only raises several questions regarding pathophysiology PML, but gives also that AIDS associated PML must be considered another entity expanding range diseases...