María Ubals
A5071925780- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Syphilis Diagnosis and Treatment
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Research on Leishmaniasis Studies
- Reproductive tract infections research
- Sex work and related issues
- HIV/AIDS oral health manifestations
- Dermatological diseases and infestations
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Hematological disorders and diagnostics
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Dermatological and COVID-19 studies
- Phytochemistry and biological activities of Ficus species
- Ear and Head Tumors
- Virology and Viral Diseases
- Respiratory viral infections research
- Tumors and Oncological Cases
Hospital Universitari Germans Trias i Pujol
2020-2024
Universitat de Barcelona
2018-2024
Fundació Lluita contra les Infeccions
2020-2024
Vall d'Hebron Hospital Universitari
2024
Institut Català de la Salut
2023
Universitat Autònoma de Barcelona
2016-2022
Barcelona Institute for Global Health
2018
<h2>Summary</h2><h3>Background</h3> In May, 2022, several European countries reported autochthonous cases of monkeypox, which rapidly spread globally. Early reports suggest atypical presentations. We aimed to investigate clinical and virological characteristics human monkeypox in Spain. <h3>Methods</h3> This multicentre, prospective, observational cohort study was done three sexual health clinics Madrid Barcelona, enrolled all consecutive patients with laboratory-confirmed from May 11 June...
Scarce data are available on what variables affect the risk of transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), development symptomatic COVID-19, and, particularly, relationship with viral load. We aimed to analyse from linked index cases COVID-19 and their contacts explore factors associated SARS-CoV-2.In this cohort study, patients were recruited as part a randomised controlled trial done between March 17 April 28, 2020, that assess if hydroxychloroquine reduced...
No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious outpatients COVID-19.Multicenter open-label, randomized, controlled trial conducted in Catalonia, Spain, between 17 March and 26 May 2020. Patients recently diagnosed <5-day of symptom onset were assigned receive HCQ (800 mg on day 1 followed by 400 once daily 6 days) or usual care. Outcomes reduction viral load nasopharyngeal...
BackgroundCurrent strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited to nonpharmacologic interventions. Hydroxychloroquine has been proposed as a postexposure therapy prevent disease 2019 (Covid-19), but definitive evidence is lacking.MethodsWe conducted an open-label, cluster-randomized trial involving asymptomatic contacts of patients with polymerase-chain-reaction (PCR)–confirmed Covid-19 in Catalonia, Spain. We randomly assigned...
BackgroundThe increasing incidence of syphilis and the limitations first-line treatment with penicillin, particularly in neurosyphilis, neonatal syphilis, pregnancy, highlight need to expand therapeutic repertoire for effective management this disease. We assessed in-vitro efficacy 18 antibiotics from several classes on Treponema pallidum subspecies (T pallidum), bacteria.MethodsUsing culture system T pallidum, we exposed pathogen a concentration range each tested antibiotic. After 7-day...
Management of syphilis, a sexually transmitted infection (STI) with increasing incidence, is challenged by drug shortages, scarcity randomised trial data, an absence non-penicillin alternatives for pregnant women penicillin allergy (other than desensitisation), extended parenteral administration neurosyphilis and congenital macrolide resistance. Linezolid was shown to be active against Treponema pallidum, the causative agent in vitro rabbit model. We aimed assess efficacy linezolid treating...
Background Tumor necrosis factor alpha (TNF-α) blockers are recognized as a risk for reactivation of granulomatous infections. Leishmaniasis has been associated with the use these drugs, although few cases have reported. Methodology We performed retrospective observational study including patients confirmed leishmaniasis acquired in Mediterranean basin that were under TNF-α therapy at moment diagnosis. Patients diagnosed our hospital from 2008 to 2018 included. Moreover, systematic review...
ABSTRACT Background Current strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are limited to non-pharmacological interventions. Hydroxychloroquine (HCQ) has been proposed as a postexposure therapy prevent Coronavirus disease 2019 (Covid-19) but definitive evidence is lacking. Methods We conducted an open-label, cluster-randomized trial including asymptomatic contacts exposed PCR-positive Covid-19 case in Catalonia, Spain. Clusters were...
BackgroundPenicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to identify viable alternatives. We tested, both in vitro and vivo, three marketed antibiotics with adequate pharmacological properties treat syphilis.MethodsWe used an culturing system of T. pallidum perform drug susceptibility testing applied quantitative PCR targeting tp0574 gene measure bacterial growth. To confirm vivo...
ABSTRACT Background There remains limited data on what variables affect risk of transmission SARS-CoV-2 and developing symptomatic Covid-19 in particular the relationship to viral load (VL). We analysed from linked index cases their contacts explore factors associated with SARS-CoV-2. Methods Patients were recruited as part a randomized control trial, conducted between March April 2020, that aimed assess if hydroxychloroquine reduced Non-hospitalised identified through local surveillance...
Abstract Background The current standard for COVID-19 diagnosis, RT-qPCR, has important drawbacks its use as a tool epidemiological control, including the need of laboratory-processing, high cost, and long turnaround from sampling to results release. Antigen-based rapid diagnostic tests (Ag-RDT) provide promising alternative this purpose. Methods We assessed analytical clinical performance Ag-RDT Panbio Ag Test (Abbott), using RT-qPCR reference test. was nasopharyngeal swabs, collected in...
Background:,Monkeypox DNA has been detected in skin lesions, saliva, oropharynx, urine, semen, and stool of patients infected during the 2022 outbreak; however, viral dynamics within these compartments remain unknown. We investigated clearance over course illness.Methods: This was an observational, prospective, multicentre study including individuals diagnosed with monkeypox hospitals sexual health clinics Spain. Participants collected swabs from their rectum, a dried blood spot, either...
We evaluated the accuracy of patient-collected skin lesions, oropharyngeal, and rectal swabs among 50 individuals enrolled in a study mpox viral dynamics. found that performance self-collected samples was similar to physician-collected samples, suggesting self-sampling is reliable strategy for diagnosing mpox.
Despite use of tecovirimat since the beginning 2022 outbreak, few data have been published on its antiviral effect in humans. We here predict efficacy using a unique set nonhuman primates (NHPs) and analyzed activity viral kinetics NHP to characterize concentration-effect relationship vivo. Next, we used pharmacological model developed healthy volunteers project Finally, dynamic was applied mpox skin lesions from 54 untreated patients, this modeling framework impact clearance lesions. At...
Background Evidence on the determinants of magnitude humoral responses and neutralizing titers in individuals with mild COVID-19 is scarce. Methods In this cohort study patients, we assessed viral load (VL) by RT-qPCR at two/three time points during acute infection, anti-SARS-CoV-2 antibodies ELISA plasma using a pseudovirus assay day 60. Results Seventy-one (65% female, median 42 years old) were recruited grouped into high &gt;7.5 Log 10 copies/mL (n=20), low, VL ≤7.5 (n=22), or as...
Background: In May 2022, England reported various cases of infection with monkeypox virus, which rapidly spread throughout other countries in Europe. Early reports this outbreak suggest atypical presentations the infection; therefore, we aimed to investigate clinical and virological characteristics infected patients.Methods: observational, prospective, multi-center study, included confirmed three sexual health clinics Madrid Barcelona from 9 June 29, 2022. Suspected patients were offered...
Treponema pallidum subsp pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws-endemic regions the tropics. However, a significant proportion CU patients remain polymerase chain reaction (PCR) negative for both bacterial agents. We aimed to identify potential additional etiological region.This population-based cohort study included children Lihir Island (Papua New Guinea) examined during yaws eradication campaign October 2013-October 2014. All consenting with...