A5056999316- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Viral-associated cancers and disorders
- COVID-19 diagnosis using AI
- Herpesvirus Infections and Treatments
- COVID-19 and healthcare impacts
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Emergency and Acute Care Studies
- Systemic Lupus Erythematosus Research
- Ultrasound in Clinical Applications
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Poxvirus research and outbreaks
- Hepatitis B Virus Studies
- Mitochondrial Function and Pathology
- Aortic Thrombus and Embolism
- CNS Lymphoma Diagnosis and Treatment
- Lipid metabolism and disorders
Hospital Del Mar
2022-2025
Hospital Universitario de La Princesa
2025
Universidad Autónoma de Madrid
2025
Instituto de Salud Carlos III
2024
Hospital del Mar Research Institute
2022-2023
Vall d'Hebron Hospital Universitari
2020-2023
Parc de Salut
2023
Municipal Institute for Medical Research
2023
Vall d'Hebron Institut de Recerca
2020-2022
Universitat Autònoma de Barcelona
2019-2022
The objective of this study was to assess the effect that triple therapy (anticoagulation plus CS plasma exchange and/or IVIGs) has on mortality risk patients with catastrophic APS (CAPS) included in CAPS Registry.Patients from Registry were grouped based their treatments: therapy; drugs but different combinations; and none treatments therapy. primary endpoint all-cause mortality. Multivariate logistic regression models used compare between groups.The cohort 525 episodes accounting for 502...
Abstract Purpose This study aims to evaluate the association between psychiatric disorders and diabetic ketoacidosis (DKA) in patients with type 1 diabetes (T1D) treated at a tertiary care hospital. Methods A propensity score-matched case-control was conducted, comprising total sample of 194 participants (97 DKA cases 97 controls without DKA). Comprehensive data were collected on clinical, anthropometric, socioeconomic characteristics, classified according international standards. Results...
We investigated the efficacy of dolutegravir/lamivudine for maintenance treatment people with HIV and previous lamivudine resistance. Open-label, single arm, multicentric clinical trial including virologically suppressed PWH historical resistance (confirmed by genotypic testing or suspected based on history), no integrase CD4+ >200 cells/mm3 whose ART was changed to if M184V/I mutation not detected in baseline proviral DNA population sequencing. Proviral next-generation sequencing (NGS)...
Background The impact of tenofovir disoproxil fumarate (TDF) antiretroviral (ART) regimens on bone health has been characterized mostly by mineral density (BMD), but recently also quality (BQ). aim this pilot study is to assess the changes in BMD and BQ after switch from TDF alafenamide (TAF) ART. Methods HIV individuals receiving TDF-based ART were randomized Bictegravir-TAF-Emtricitabine or remain same regimen. At baseline 24-weeks randomization, participants underwent (BMD) DXA assessment...
This real-world study compared the safety and effectiveness of Dolutegravir/lamivudine (D/L) Bictegravir/Emtricitabine/Tenefovir alafenamide (B/F/T) switch therapy regimens for people living with HIV (PLWH).The retrospective conducted from April 2019 to November 2022, included PLWH < 50 copies/mL HIV-RNA prior recruitment who initiated either D/L or B/F/T switching therapy. The primary objective was evaluate treatment discontinuation rates; virologic outcomes were also evaluated.690...
Abstract Purpose To design a randomized clinical trial to assess the efficacy and safety of favipiravir in patients with COVID-19 disease pneumonia. Methods A randomized, double blind, placebo-controlled pneumonia was conducted three Spanish sites. Randomization 1:1 or placebo (in both groups added Standard Care) performed treat The primary endpoint “time improvement,” measured as an improvement for ≥ two categories on 7-point WHO ordinal scale up 28 days' time frame. Results Forty-four were...
To compare clinical characteristics, outcomes, and resource consumption of patients with coronavirus disease 2019 (COVID-19) seasonal influenza requiring supplemental oxygen.Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted because between 2017 2019, or COVID-19 March May 2020 oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality hospitalization costs. Attempted sample size to detect an 11% difference in was 187 per...
Abstract Objective The HIV infection is a chronic disease that causes neurocognitive impairment (NI) and has been related with early development of frailty. We aimed to study the main risk factors for disorders frailty in older adults. Materials methods Cross-sectional 40 individuals than 65 years under antiretroviral therapy Hospital del Mar (Barcelona) recruited between November 2019 October 2020. Data obtained through clinical scores blood sample evaluate NI analyzed non-parametric tests...
Abstract People living with human immunodeficiency virus (HIV) are the individuals most affected by current Monkeypox outbreak that was first announced in May 2022. Here we report Pan‐pox‐specific T‐cell responses a cohort of HIV‐1‐infected after receiving nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination safe without major side effects. Dose‐sparing i.d. superior to s.c. promoted polyfunctionality, expression...
Objectives The aim of the study was to investigate dynamics cytomegalovirus (CMV) replication and CMV‐specific immune response recovery after antiretroviral treatment (ART) initiation in patients with advanced HIV infection. Methods A prospective observational infection CD4 counts < 100 cells/µL carried out (September 2015 July 2018). viral load (VL), count CMV VL were determined by quantitative polymerase chain reaction (PCR) at baseline 4, 12, 24 48 weeks, QuantiFERON‐CMV assay weeks....
Introduction. Long-term non-progressors (LTNPs) are HIV-infected individuals (HIV+) whose viral replication is controlled. However, these experience complications associated with HIV, among them, bone remodeling impairment. This study aims to perform a comprehensive health assessment and its association the inflammatory status of HIV+ LTNPs. A cross-sectional was conducted comparing strength components (bone mineral density tissue quality) between age-, sex-, comorbidities-matched groups...
The objective was to compare clinical characteristics, outcomes, and economic differences in complicated urinary tract infections (cUTI) caused by extensively drug-resistant Pseudomonas aeruginosa (XDR P. aeruginosa) extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-K. pneumoniae). A retrospective study conducted at a tertiary care hospital. Patients with XDR ESBL-K. cUTIs were compared. primary outcome failure day 7 the end of treatment (EOT). Secondary outcomes: 30-...
We evaluated the impact of hepatic steatosis-insulin resistance (HS-IR) and liver fibrosis (LF) on type 2 diabetes mellitus (DM2) using triglyceride-glucose (TyG) Fibrosis-4 (FIB-4). The incidence DM2 was 12.9 [95% confidence interval (CI), 16.9–9.7] 9.8 (95% CI, 6.9–13.6) per 1000 person-years in HS-IR LF. prevalence significantly lower at 12 24 months with TDF + (3TC or FTC) RPV [hazard ratio (HR) 0.5 0.3–0.8], P < 0.01 months; 0.6 [0.4–0.9], = months].
Abstract Introduction People with HIV (PWH) poor immune response despite adequate antiretroviral treatment (ART) are susceptible to non-AIDS-related health issues. This study seeks evaluate bone quality in immunological nonresponders (INRs) comparison those proper (IRs) using vivo microindentation quantify quality, addition conventional mineral density (BMD) evaluations. Methods A cross-sectional was conducted at Hospital del Mar Barcelona from January 2019 June 2023. Participants were...
None declared.