A5032925281- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Bone and Joint Diseases
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Hematological disorders and diagnostics
- Nosocomial Infections in ICU
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Bone health and osteoporosis research
- HIV/AIDS oral health manifestations
- Medication Adherence and Compliance
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
Hospital Del Mar
2015-2024
Instituto de Salud Carlos III
2023-2024
Centro de Investigación Biomédica en Red
2023-2024
Universitat Pompeu Fabra
2011-2024
Parc de Salut
2010-2024
Hospital del Mar Research Institute
2014-2023
Municipal Institute for Medical Research
2014-2023
Universitat Autònoma de Barcelona
2012-2022
Heidelberg University
2021
University Hospital Heidelberg
2021
Objective To assess the effectiveness of simplified medication adherence questionnaire (SMAQ) in identifying non-adherent patients. Design Prospective observational study adherence. The six-item SMAQ was developed. following aspects were evaluated: (i) criterion validity, comparison with electronic monitoring; (ii) construct association between adherence, as defined by SMAQ, and virological outcomes; (iii) reliability, internal consistency reproducibility. Patients A group 3004 unselected...
To assess the effect of antiretroviral therapy (ART) adherence on survival in HIV-infected patients.Cohort study at a single hospital Barcelona, Spain.Data patients older than 18 years age who began ART during period 1990 to 1999 were analyzed. Patients considered nonadherent if total dose drug was less 90% that prescribed. Adherence assessed through self-report and pharmacy appointments. Cox regression with time-dependent variables used.A 1219 included. The first monotherapy 23.7% cases,...
Data regarding the most efficacious and least toxic schedules for use of colistin are scarce. The aim this study was to determine incidence potential risk factors colistin-associated nephrotoxicity including plasma levels. A prospective observational cohort conducted over one year in patients receiving intravenous methanesulfonate sodium (CMS). Blood samples levels were collected immediately before (Cmin) 30 minutes after CMS infusion (Cmax). Renal function assessed at baseline, on day 7 end...
We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) whom virologic suppression had been achieved.We randomly assigned 460 adults who were taking two nucleoside reverse-transcriptase inhibitors and at least one whose plasma HIV-1 RNA levels less than 200 copies per milliliter previous six months to switch from nevirapine (155 patients), efavirenz (156), (149). The primary end...
OBJECTIVE—To assess the prevalence in HIV-infected patients of metabolic syndrome as defined by National Cholesterol Education Program, i.e., three or more following components: abdominal obesity, hypertriglyceridemia, low HDL cholesterol, high blood pressure, and fasting glucose. RESEARCH DESIGN AND METHODS—In this cross-sectional study, 710 managed at outpatient clinic a tertiary hospital during 2003 completed study protocol consisting medical examination laboratory analysis after 12-h...
Background: Switching to raltegravir in selected patients treated with ritonavir-boosted protease inhibitors may result similar efficacy and lower plasma lipids. Methods: SPIRAL is a 48-week multicentre, open-label trial which HIV-infected adults less than 50 copies/ml of HIV RNA for at least the previous 6 months on inhibitor-based therapy were randomized (1: 1) switch from inhibitor or continue therapy. Primary endpoint was proportion free treatment failure (noncompleter = failure) 48...
There is scarce evidence on the use of eosinophil count as a marker outcome in patients with infection. The aim this study was to evaluate whether changes count, well neutrophil-lymphocyte ratio (NLCR), could be used clinical markers bacteremia.We performed retrospective first episode community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total 2,311 were included. Cox regression analyze behaviour NLCR survivors non-survivors.In adjusted...
ABSTRACT HIV infection and antiretroviral therapies have detrimental effects on bone metabolism, but data their impact fracture risk are controversial. We conducted a population-based cohort study to explore the association between clinical diagnosis of hip major osteoporotic risk. Data were obtained from SIDIAPQ database, which contains information for >2 million patients in Catalonia, Spain (30% population). screened database identify participants with infection, ascertained...
Microbial translocation has been associated with an increase in immune activation and inflammation HIV infection despite effective highly active antiretroviral therapy. It shown that some probiotics have a beneficial effect by reducing intestinal permeability and, consequently, microbial translocation.To assess changes after treatment (Saccharomyces boulardii) HIV-1-infected patients virologic suppression.A double-blind, randomized, placebo-controlled trial was conducted 44 nonconsecutive...
Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared triple plus 2 nucleos(t)ides for maintenance human immunodeficiency virus type 1 (HIV-1) suppression.This a multicenter, open-label, trial (margin 12%). Patients HIV-1 RNA <50 copies/mL 6 months or longer on (tenofovir disoproxil fumarate emtricitabine abacavir lamivudine) no resistance were randomized continue (n = 128) switch 129). The primary endpoint proportion...
BackgroundFactors affecting outcomes of SARS-CoV-2 infection in people living with HIV are unclear. We assessed the factors associated diagnosis and severe among HIV.MethodsWe did a retrospective cohort study using data from PISCIS Catalonia (Spain) between March 1 Dec 15, 2020. linked integrated health-care, clinical, surveillance registries through Public Data Analysis for Health Research Innovation Program (PADRIS) to obtain on diagnosis, chronic comorbidities, as well clinical mortality...
Bone loss is a normal feature of aging. Accelerated bone demineralization multifactorial process; recent reports have suggested that HIV infection, perhaps in association with protease inhibitor (PI) therapy, an additional risk factor for osteopenia [1,2]. However, changes mineral metabolism, histomorphometry or density had been described HIV-infected patients before the era highly active antiretroviral therapy (HAART) [3–5]. The aim this study to define role infection and development loss....
Non-nucleoside reverse transcriptase inhibitor-containing regimens may be a valid alternative to protease for initial antiretroviral therapy, but date few studies comparing these two strategies have been performed.To evaluate the efficacy and safety of nelfinavir or nevirapine associated zidovudine/lamivudine in HIV-infected naive patients.Randomized, open-label, multicentre trial.Twelve centres Spain (9) Argentina (3).One hundred forty-two patients without AIDS.Patients received combivir...
Objectives: To assess the effect of early syphilis on HIV viral load (VL) and CD4 cell count in patients with to analyze factors associated changes VL count. Design: Multicenter study a series who were diagnosed infection during 2004 through 2005. Patients started or changed their highly active antiretroviral therapy (HAART) regimen analysis period excluded. Results: One hundred eighteen analyzed: 95.8% men, mean patient age was 38.2 years, 83.9% homosexual 50.8% at time diagnosed, diagnoses...
The OK04 trial has shown that 48 weeks of lopinavir-ritonavir monotherapy with reintroduction nucleosides as needed was noninferior to continuation triple therapy 2 and in patients prior stable suppression. However, it is still uncertain if this experimental strategy can maintain suppression the long term.Patients entered noninferiority (upper limit 95% confidence interval: +12%) no history virological failure while receiving a protease inhibitor plus lopinavir/ritonavir, HIV RNA <50 copies...
Patients with infected arthroplasties are normally treated a two-stage exchange procedure using polymethylmethacrylate bone cement spacers impregnated antibiotics. However, may act as foreign body to which micro-organisms adhere and grow. In this study it was hypothesised that subclinical infection be diagnosed sonication of the surface biofilm spacer. The aims were assess presence through spacer at time second-stage procedure, determine relationship between clinical outcome. Of 55 patients...
Little is known about hypertension in the HIV-infected population. This study aimed to assess prevalence of and related factors patients.In this prospective cross-sectional study, 710 patients (626 on combination antiretroviral therapy 84 naive) managed at outpatient clinic a tertiary hospital during 2003 802 controls completed protocol consisting medical examination 6-month follow-up period including three control visits.Hypertension was 13.1% 13.5% group. Age (per 10-year increment) (odds...
Whether or not combination antiretroviral therapy (CART) alone directly contributes to accelerating atherosclerosis in HIV-infected patients has been studied depth. This study aimed ascertain the relationship between this and subclinical carotid according cardiovascular risk.Sixty-eight with < =1 risk factors 64 > =2 completed protocol consisting of clinical, laboratory, vascular evaluation by high-resolution B-mode ultrasonography. Univariate multivariate logistic regression analyses were...