A5037517749- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Human Health and Disease
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- Lysosomal Storage Disorders Research
- HIV Research and Treatment
- Neurological diseases and metabolism
- Cholinesterase and Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Cardiac tumors and thrombi
- Vector-borne infectious diseases
- Receptor Mechanisms and Signaling
- Autoimmune Neurological Disorders and Treatments
- Amoebic Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Mollusks and Parasites Studies
- Genetic Syndromes and Imprinting
- Barrier Structure and Function Studies
SUNY Upstate Medical University
2022
Consejo Superior de Investigaciones Científicas
2009
Instituto Cajal
2007
Centro de Biología Molecular Severo Ochoa
2006
University of Pittsburgh
1995
Franklin University
1995
Virginia Commonwealth University Medical Center
1973-1976
American University of Beirut Medical Center
1973
Neuropathologic and neurochemical correlates of psychosis were determined using brain tissue from 27 autopsy-confirmed cases Alzheimer's disease. The densities senile plaques neurofibrillary tangles in the middle frontal superior temporal cortex, prosubiculum, entorhinal cortex hippocampus. concentrations norepinephrine, dopamine, serotonin, metabolites these biogenic amines, specific activity choline acetyltransferase also four cortical regions as well substantia nigra, thalamus, amygdala,...
Abstract Folic acid (5 mg) was given daily, for not less than one menstrual period before conception and until the tenth week of pregnancy, to 81 women (FS) with a history previous neural tube defect (NTD) birth. There no NTD recurrence among this group or offspring further 20 (PS) whose folic supplementation fell short full regime. In another 114 who became pregnant without (US), there were four recurrences (3.5 per cent). Our results suggest that might be an effective method primary...
Temporal cortical sections from postmortem brains of individuals without any dementing condition and with different degrees severity Alzheimer's disease (AD) evaluated by the Clinical Dementia Rating scale (CDR 0-CDR 3) were analyzed using immunohistochemical procedures. To demonstrate amyloid-beta-peptide (Abeta) deposition neurofibrillary pathology, two monoclonal antibodies used, a human CERAD Abeta (10D5) antibody raised against N-terminal region Abeta-peptide, an paired helical...
We studied 16 brains of patients with Alzheimer's disease for left-right differences, or similarities, in the density senile plaques (SPs) neurofibrillary tangles (NFTs). Counts were made SPs and NFTs on left right side five different brain areas, which included middle frontal, superior temporal, prosubiculum hippocampus (HPR), entorhinal cortex (HEN), basal nucleus Meynert. The was bilaterally symmetrical all regions except Meynert technical problems may have occurred sampling. In contrast...
A community engaged passive surveillance program was utilized to acquire ticks and associated information throughout New York state. Ticks were speciated screened for several tick-borne pathogens. Of these ticks, only I . scapularis commonly infected with pathogens of human relevance, including B burgdorferi , miyamotoi phagocytophilum microti Powassan virus. In addition, the geographic temporal distribution tick species determined. This enabled construction a powerful visual analytical...
• Ninety extraocular muscle (EOM) biopsy specimens from 80 children with strabismus and normal ocular alignment were studied by light microscopy, enzyme histochemistry, electron microscopy. Light microscopy showed considerable variation in fiber shape size sarcomere disruption, sharp increases endomysial perimysial collagen, numerous vacuoles subsarcolemmal inclusions. Electron disruption of myofilaments, nemaline rods, abnormal mitochondria, leptomeric profiles, occasional "myelin figures,"...
The specific activities of the cholinergic enzymes, choline acetyltransferase and acetylcholinesterase, as well density muscarinic binding sites, were determined in five corresponding left right regions 16 brains obtained at autopsy from patients with histologically confirmed Alzheimer's disease. While a significant proportion individual specimens exhibited left-right asymmetries deficits, bilateral symmetry was rule for frontal temporal cortex, basal nucleus, prosubiculum hippocampus. In...
Two metastases from an atrial myxoma occurred in the right common carotid artery distribution of a 34-year-old man. One metastasis caused phenomenon intracranial pseudoaneurysm distal branch middle cerebral artery. The other resulted unusual radiographic appearance tremendous, "bubbly" expansion temporal bone.
ABSTRACT A community engaged passive surveillance program was utilized to acquire ticks and associated information throughout New York state. Ticks were speciated screened for several tick-borne pathogens. Of these ticks, only I. scapularis commonly infected with pathogens of human relevance, including B. burgdorferi , miyamotoi A. phagocytophilum microti Powassan virus. In addition, the geographic temporal distribution tick species determined. This enabled construction a powerful visual...
Elevated cerebral levels of amyloid beta-protein (Aβ) occur universally in Alzheimer's disease, yet only a few patients show evidence increased Aβ production. This observation suggests that many, perhaps most, cases AD are caused by faulty clearance is produced at normal throughout life. In this context, lipoprotein receptor-related protein-2 (LRP2)/megalin, which plays an important role mediating clearance, attractive candidate gene for genetic asscociation with AD. To investigate possible...