A5076485405- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Cardiovascular and exercise physiology
- Respiratory and Cough-Related Research
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Delphi Technique in Research
- COVID-19 Clinical Research Studies
- Obstructive Sleep Apnea Research
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Chronic Disease Management Strategies
Hospital General Universitario Gregorio Marañón
2016-2025
Universidad Complutense de Madrid
2016-2025
Universidad del Sinú
2025
Ayuntamiento de Sevilla
2023
Hospital Juan Ramón Jiménez
2023
Hospital Clínic de Barcelona
2023
Complejo Hospitalario Universitario de Santiago
2023
Respiratory Clinical Trials
2021
Universidad Autónoma de Madrid
2020
Institute of Cardiology
2020
Evidence-based recommendations on the clinical use of cardiopulmonary exercise testing (CPET) in lung and heart disease are presented, with reference to assessment intolerance, prognostic evaluation therapeutic interventions ( e.g. drugs, supplemental oxygen, training). A commonly used grading system for evidence-based guidelines was applied, grade recommendation ranging from A, highest, D, lowest. For symptom-limited incremental exercise, CPET indices, such as peak O 2 uptake V ′O ), at...
Several cellular and molecular alterations have been described in skeletal respiratory muscles of patients with chronic obstructive pulmonary disease (COPD), but information on potential abnormalities mitochondrial function is scarce. The aim the present study was to investigate vastus lateralis (VL) external intercostalis (EI) COPD patients. Biopsies from VL EI were obtained during surgery for lung cancer 13 mild moderate (age 68±6 yrs, forced expiratory volume one second (FEV 1 ) 66±15%...
The efficacy of mepolizumab is well documented in severe eosinophilic asthma (SEA), although the stringent selection criteria adopted by SEA clinical trials limits generalizability results. Our study evaluated effectiveness and safety patients with Spain. primary endpoint was change rate clinically significant exacerbations 12 months after starting compared to baseline prior treatment. Patients were stratified blood eosinophil counts. We conducted a multicentric observational cohort treated...
The effects of two 8 week programmes reconditioning in chronic obstructive pulmonary disease (COPD) patients were studied. Forty one subjects (mean+/-SD) 644.5) yrs; forced expiratory volume second (FEV1) 1.09+/-0.16 L; 40.6+/-6.2% predicted randomly assigned either to supervised training on a treadmill, 4 days x week(-1) (group S; n=21) or walking 3 km 1 h week(-1), self-monitored with pedometer, weekly visits encourage adherence SM; n=20). Patients evaluated the respiratory diseases...
This study evaluated the effects of aclidinium bromide, a long-acting muscarinic antagonist indicated for maintenance treatment chronic obstructive pulmonary disease (COPD), on exercise endurance, dyspnea, lung hyperinflation, and physical activity. In this randomized, double-blind, crossover study, patients with stable COPD moderate-to-severe airflow limitation received 400 μg twice daily or placebo via Genuair®/Pressair® 3 weeks (2-week washout between periods). The primary endpoint was...
The effects of two 8-week programmes exercise reconditioning on the time constants (tau) pulmonary gas exchange, ventilatory and heart rate responses to moderate intensity in patients with chronic obstructive disease (COPD) were studied. Thirty-five subjects (mean+/-SD 64+/-5 yrs; forced expiratory volume one second (FEV1) 1.09+/-0.17 L; 41+/-6.2% predicted) randomly assigned either supervised (s) training a treadmill, 4 days x week(-1) (group S; n=21) or self-monitored (SM) walking 3 km 1 h...
The endurance time during constant high work-rate exercise ( t LIM ) is used to assess capacity in patients with chronic obstructive pulmonary disease and as an outcome measure for rehabilitation. Our study was designed establish the minimum clinically important difference . measured 105 (86 males) before after 8-week outpatient rehabilitation programme. Subjects were asked identify, from a five-point Likert scale, perceived change their performance immediately upon completion of tests....
What is the central question of this study? We explored whether experimental cancer-induced cachexia may alter mitochondrial respiratory chain (MRC) complexes and oxygen uptake in peripheral muscles,and signalling pathways, proteasome oxidative stress influence that process. main finding what its importance? In cancer cachectic mice, MRC consumption were decreased diaphragm gastrocnemius. Blockade nuclear factor-κB mitogen-activated protein kinase actions partly restored muscle mass force...
To analyze changes in the incidence, diagnostic procedures, comorbidity, length of hospital stay (LOHS), costs and in-hospital mortality (IHM) for patients with bronchiectasis who were hospitalized Spain over a 10-year period.We included all admissions diagnosed as primary or secondary diagnosis during 2004-2013.282,207 admitted to study. After controlling possible confounders, we observed significant increase incidence hospitalizations study period when was diagnosis. When decline...
<h3>Background</h3> Exhausting exercise reduces the mitochondrial DNA (mtDNA) content in skeletal muscle of healthy subjects due to oxidative damage. Since patients with chronic obstructive pulmonary disease (COPD) suffer enhanced stress during exercise, it was hypothesised that mtDNA will be further reduced. <h3>Objective</h3> To investigate effects above and below lactate threshold (LT) on COPD. <h3>Methods</h3> Eleven COPD (67±8 years; forced expiratory volume 1 s (FEV<sub>1</sub>)...
Objective. To study the prevalence of anxiety and depression in patients with asthma to identify associated factors. Material methods. The was based on individual data subjects aged ≥18 years drawn from 2006 Spanish National Health Survey. We identified asthmatic individuals through a specific questionnaire. Presence or assessed using following questions: () "Have you suffered over previous 12 months?" "Has your medical doctor confirmed diagnosis?" consumed antidepressants prescribed by...
Exercise triggers skeletal muscle oxidative stress in patients with chronic obstructive pulmonary disease (COPD). The objective of this research was to study the specific sites reactive oxygen species (ROS) production mitochondria isolated from COPD and its relationship local induced by exercise. Vastus lateralis biopsies were obtained 16 (66 ± 10 yr; FEV(1), 54 12% ref) 14 control subjects normal lung function who required surgery because cancer (65 7 91 14% at rest after In these we...