A5037474136- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiovascular and exercise physiology
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Pulmonary Hypertension Research and Treatments
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Delphi Technique in Research
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Pleural and Pulmonary Diseases
- Health and Wellbeing Research
- Pediatric health and respiratory diseases
- Emergency and Acute Care Studies
- Medical Imaging and Pathology Studies
- Air Quality and Health Impacts
- Cardiac Health and Mental Health
- Restraint-Related Deaths
Queen's University
2016-2025
Kingston General Hospital
2015-2024
Kingston Health Sciences Centre
2018-2024
Canadian Respiratory Research Network
2016-2023
University of Saskatchewan
2022
ORCID
2020-2021
Brain Physiology Lab
2020
McGill University Health Centre
2020
Australian and New Zealand Intensive Care Society
2019
Austin Health
2011-2017
Linda Nici, Claudio Donner, Emiel Wouters, Richard Zuwallack, Nicolino Ambrosino, Jean Bourbeau, Mauro Carone, Bartolome Celli, Marielle Engelen, Bonnie Fahy, Chris Garvey, Roger Goldstein, Rik Gosselink, Suzanne Lareau, Neil MacIntyre, Francois Maltais, Mike Morgan, Denis O’Donnell, Christian Prefault, Jane Reardon, Carolyn Rochester, Annemie Schols, Sally Singh, and Thierry Troosters, on behalf of the ATS/ERS Pulmonary Rehabilitation Writing Committee
Section:ChooseTop of pageAbstract <<ContentsExecutive SummaryIntroductionMethodsDefinitionNeurophysiological Mechan...Dyspnea MeasurementEvaluation and TreatmentResearch PrioritiesConclusionReferencesCITING ARTICLES
The role of dynamic hyperinflation (DH) in exercise limitation chronic obstructive pulmonary disease (COPD) remains to be defined. We examined DH during 105 patients with COPD (FEV1 = 37 ± 13% predicted; mean SD) and studied the relationships between resting lung volumes, exercise, peak oxygen consumption (V˙ o 2). Patients completed function tests incremental cycle tests. measured change inspiratory capacity (ΔIC) reflect changes DH. During 80% showed significant above values. IC decreased...
The aim of this study was to test the hypothesis that use tiotropium, a new long-acting anticholinergic bronchodilator, would be associated with sustained reduction in lung hyperinflation and, thereby, improve exertional dyspnoea and exercise performance patients chronic obstructive pulmonary disease. A randomised, double-blind, placebo-controlled, parallel-group conducted 187 (forced expiratory volume one second 44±13% pred): 96 received 18 µg tiotropium 91 placebo once daily for 42 days....
Evidence-based recommendations on the clinical use of cardiopulmonary exercise testing (CPET) in lung and heart disease are presented, with reference to assessment intolerance, prognostic evaluation therapeutic interventions ( e.g. drugs, supplemental oxygen, training). A commonly used grading system for evidence-based guidelines was applied, grade recommendation ranging from A, highest, D, lowest. For symptom-limited incremental exercise, CPET indices, such as peak O 2 uptake V ′O ), at...
Background: Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations inhaled corticosteroids, long-acting β-agonists, and anticholinergic bronchodilators is common but unstudied. Objective: To determine whether combining tiotropium salmeterol fluticasone–salmeterol improves clinical outcomes in adults to COPD compared alone. Design: Randomized, double-blind, placebo-controlled trial conducted from October 2003 January 2006. Setting: 27 academic community...
There is considerable intersubject variability in the perceived intensity of breathlessness for a given level activity among patients with chronic airflow limitation (CAL). To examine possible factors contributing to this we compared breathing pattern parameters, dynamic operational lung volumes, and Borg dyspnea ratings 23 severe CAL 10 healthy age-matched normal subjects during cycle ergometry symptom-limitation. Patients had significantly (p < 0.01) higher levels ventilation (% maximal...
Changes in lung hyperinflation, dyspnea, and exercise endurance are important outcomes assessing therapeutic responses chronic obstructive pulmonary disease (COPD). Therefore, we studied the reproducibility of Borg dyspnea ratings, inspiratory capacity (IC; to monitor hyperinflation), time during constant-load symptom-limited cycle 29 patients with COPD (FEV1 = 40 ± 2% predicted; mean SEM). Responsiveness was also by determining acute effects nebulized 500 μ g ipratropium bromide (IB) or...
We wished to determine which resting spirometric parameters best reflect improvements in exercise tolerance and exertional dyspnea response acute high-dose anticholinergic therapy advanced COPD. studied 29 patients with stable COPD (FEV1 = 40 ± 2% predicted [%pred]; mean SEM) moderate severe chronic dyspnea. In a double-blind placebo-controlled cross-over study, performed spirometry symptom-limited constant-load cycle before 1 h after receiving 500 μ g of nebulized ipratropium bromide (IB)...
We compared qualitative aspects of the sensory experience exertional breathlessness in normal subjects and patients with chronic airflow limitation (CAL) sought a physiologic rationale for these. Twelve (66 +/- 2 yr age, mean SEM) severe CAL (FEV1 = 37 5% predicted) 12 age-matched 103 were studied. Perceived inspiratory difficulty (BorgIN), effort (esophageal pressure expressed as fraction maximal esophageal at isovolume [Pes/PImax]), breathing pattern, operational lung volumes...
This study examined the effects of bronchodilator-induced reductions in lung hyperinflation on breathing pattern, ventilation and dyspnoea during exercise chronic obstructive pulmonary disease (COPD). Quantitative tidal flow/volume loop analysis was used to evaluate abnormalities dynamic ventilatory mechanics their manipulation by a bronchodilator. In randomised double-blind crossover study, 23 patients with COPD (mean±sem forced expiratory volume one second 42±3% predicted value) inhaled...
Smokers with a relatively preserved FEV(1) may experience dyspnea and activity limitation but little is known about underlying mechanisms.To examine ventilatory constraints during exercise in symptomatic smokers GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage I chronic obstructive lung disease (COPD) so as to uncover potential mechanisms of curtailment.We compared resting pulmonary function responses (breathing pattern, operating volumes, gas exchange) incremental cycle...
The mechanisms underlying dyspnea in interstitial lung disease (ILD) and chronic obstructive pulmonary (COPD) are unknown.To examine whether the relationship between inspiratory neural drive to diaphragm exertional intensity is different ILD COPD, given marked differences static respiratory mechanics these conditions.We compared sensory-mechanical relationships patients with ILD, healthy control subjects (n = 16 each) during incremental cycle exercise diaphragmatic electromyography (EMGdi)...
There is limited data on the risk factors and phenotypical characteristics associated with spirometrically confirmed COPD in never-smokers general population.To compare by gender severity of airway obstruction ever-smokers.We analysed from 5176 adults aged 40 years older who participated initial cross-sectional phase population-based, prospective, multisite Canadian Cohort Obstructive Lung Disease study. Never-smokers were defined as those a lifetime exposure <1/20 pack year. Logistic...
Several studies in mild chronic obstructive pulmonary disease (COPD) have shown a higher than normal ventilatory equivalent for carbon dioxide ([Formula: see text]e/[Formula: text]co2) during exercise. Our objective was to examine gas exchange abnormalities and the mechanisms of high [Formula: text]co2 COPD its impact on dyspnea exercise intolerance.Twenty-two subjects (11 patients with GOLD [Global Initiative Chronic Obstructive Lung Disease] grade 1B COPD, 11 age-matched healthy control...
Rationale: Studies of excised lungs show that significant airway attrition in the “quiet” zone occurs early chronic obstructive pulmonary disease (COPD).Objectives: To determine if total number airways quantified vivo using computed tomography (CT) reflects airway-related changes and is associated with lung function decline independent emphysema COPD.Methods: Participants multicenter, population-based, longitudinal CanCOLD (Canadian Chronic Obstructive Lung Disease) study underwent...
Among patients with chronic obstructive pulmonary disease (COPD), those the lowest maximal inspiratory pressures experience greater breathing discomfort (dyspnea) during exercise. In such individuals, muscle training (IMT) may be associated improvement of dyspnea, but mechanisms for this are poorly understood. Therefore, we aimed to identify physiological in dyspnea and exercise endurance following COPD low pressure (Pi max ). The effects 8 wk controlled IMT on respiratory function,...
We studied interrelationships between exercise endurance, ventilatory demand, operational lung volumes, and dyspnea during acute hyperoxia in ventilatory-limited patients with advanced chronic obstructive pulmonary disease (COPD). Eleven COPD (FEV1.0 = 31 ± 3% predicted, mean SEM) respiratory failure (PaO2 52 2 mm Hg, PaCO2 48 Hg) breathed room air (RA) or 60% O2 two cycle tests at 50% of their maximal capacity, randomized order. Endurance time (Tlim), intensity (Borg Scale), ventilation (V˙...