A5006901483- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Intensive Care Unit Cognitive Disorders
- Chronic Disease Management Strategies
- Pneumonia and Respiratory Infections
- Nursing Diagnosis and Documentation
- Cardiac Health and Mental Health
- Tracheal and airway disorders
- Family and Patient Care in Intensive Care Units
- Sleep and related disorders
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- High Altitude and Hypoxia
- Pleural and Pulmonary Diseases
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Emergency and Acute Care Studies
Medico
2006-2024
Presidio Ospedaliero
2011-2021
International Flame Research Foundation
2018-2021
Italian Association for Cancer Research
2014
Istituti Clinici Scientifici Maugeri
2005-2010
Fondazione Salvatore Maugeri
1998-2010
Abilities In Motion
2010
Providence VA Medical Center
2009
Brown University
2009
Mount Sinai Beth Israel
2009
Section:ChooseTop of pageAbstract <<Executive SummaryContentsOverviewIntroductionMethodsDefinition and ConceptExercise TrainingPulmonary Rehabilitation ...Behavior Change Colla...Body Composition Abnormal...Physical ActivityTiming Pulmonary Rehab...Patient-centered OutcomesProgram OrganizationHealth Care UseMoving ForwardReferencesCITING ARTICLES
Linda Nici, Claudio Donner, Emiel Wouters, Richard Zuwallack, Nicolino Ambrosino, Jean Bourbeau, Mauro Carone, Bartolome Celli, Marielle Engelen, Bonnie Fahy, Chris Garvey, Roger Goldstein, Rik Gosselink, Suzanne Lareau, Neil MacIntyre, Francois Maltais, Mike Morgan, Denis O’Donnell, Christian Prefault, Jane Reardon, Carolyn Rochester, Annemie Schols, Sally Singh, and Thierry Troosters, on behalf of the ATS/ERS Pulmonary Rehabilitation Writing Committee
Though exercise training is part of most pulmonary rehabilitation programs, whether there a physiologic basis for increased tolerance unclear. We sought to determine patients with chronic obstructive disease (COPD) are capable obtaining effect, as manifested by reduction in blood lactate and ventilation e) at given level exercise. also work rate determines the size effect. Nineteen participants COPD predominantly moderate severity an inpatient program performed two cycle ergometer tests low...
Background —Nocturnal Cheyne-Stokes respiration (CSR) occurs frequently in patients with chronic heart failure (CHF), and it may be associated sympathetic activation. The aim of the present study was to evaluate whether CSR could affect prognosis CHF. Methods Results —Sixty-two CHF left ventricular ejection fraction ≤35%, NYHA class II III, underwent clinical evaluation, Doppler echocardiography, ergospirometry, phenylephrine test, Holter recording, a sleep occurrence CSR, expressed as...
To assess physiologic effects of continuous positive airway pressure (CPAP) and end-expiratory (PEEP) during noninvasive support ventilation (PSV) in patients with acute exacerbation chronic obstructive pulmonary disease (COPD), we measured seven the breathing pattern, lung mechanics, diaphragmatic effort (PTPdi), arterial blood gases under four conditions: (1) spontaneous (SB); (2) CPAP; (3) PSV 10 cm H2O; (4) plus PEEP (PEEP + PSV). CPAP were set between 80 90% dynamic intrinsic (PEEPidyn)...
Chronic obstructive pulmonary disease (COPD) patients with chronic ventilatory failure (CVF) are more likely to develop exacerbations, which an important determinant of health-related quality life (HRQL). Long-term noninvasive positive-pressure ventilation (NPPV) has been proposed in addition long-term oxygen therapy (LTOT) treat CVF but little information is available on its effects HRQL and resource consumption. Therefore, the current authors undertook a 2-yr multicentric, prospective,...
The expression of nuclear factor (NF)-κB is an indicator cellular activation and inflammatory mediator production. aim the present study was to characterise localisation p65, major subunit NF-κB, in bronchial mucosa patients with chronic obstructive pulmonary disease (COPD), examine relationship between p65 status. Bronchial biopsies were obtained from 14 smokers COPD, 17 normal lung function 12 nonsmokers function. number positive (+) cells quantified by immunohistochemistry three groups...
Rationale: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) these phenotypes cluster within families.Objectives: To determine (1) the severity of COPD (2) show aggregation families individuals with COPD.Methods: Index cases their smoking siblings underwent spirometry were offered high-resolution computed tomography scans thorax assess emphysema.Measurements Main Results: A total...
To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess effects of combination positive end-expiratory pressure (PEEP) pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanics eight ventilator-dependent COPD patients. The patients' breathing pattern, lung mechanics, diaphragmatic effort (PTPdi), tension-time index (TTdi), arterial blood gases were measured during...
The helmet, a transparent latex-free polyvinyl chloride cylinder linked by metallic ring to soft collar that seals the helmet around neck, has been recently proposed as an effective alternative conventional face mask deliver pressure support ventilation (PSV) during noninvasive in patients with acute respiratory failure. We tested hypothesis mechanical characteristics of (large internal volume and high compliance) might impair patient-ventilator interactions compared standard mask. Breathing...
The relation between smoking, chronic obstructive pulmonary disease (COPD), and lung cancer (LC) is an open field of investigation. A higher frequency adenocarcinoma has been reported in patients with COPD. Heat shock proteins (Hsps) are implicated tumoral cell growth differentiation. aim the present study was to investigate expression Hsp60 Hsp10 bronchial biopsies from smokers COPD 10 evaluate association Hsps carcinogenetic steps LC.An immunohistochemical performed for 35...
Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality affecting large number individuals in both developed developing countries it represents significant financial burden for patients, families society. Pulmonary rehabilitation (PR) multidisciplinary program that integrates components exercise training, education, nutritional support, psychological support self-care, resulting an improvement dyspnea, fatigue quality life. Despite its proven effectiveness...
The increasing prevalence of obesity in both developed and developing countries is one the most serious public health problems has led to a global epidemic. Obesity greatest risk factors obstructive sleep apnea (OSA), which found 60 70% obese patients mainly due buildup fat tissue upper portion thorax neck. aim present randomized clinical trial assess daytime sleepiness, architecture pulmonary function with severe before after bariatric surgery.This randomized, controlled trial, was...
Rationale: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to genetic variants. Most studies have been focused on genome-wide common variants without a specific focus coding variants, but and rare may also affect COPD susceptibility.Objectives: To identify associated with COPD.Methods: We tested nonsynonymous, splice, stop derived from the Illumina HumanExome array for association five study populations enriched COPD. evaluated single minor allele frequency...
During hypoxia ATP degradation to uric acid is increased in animal models and humans. To assess the reliability of an overnight increase excretion as a marker nocturnal hypoxemia, we selected 10 normal volunteers (7 males 3 females), 29 COPD patients (26 49 subjects with obstructive sleep apnea (OSA) (43 6 females). The underwent standard polysomnography, which was repeated 14 nasal continuous positive airway pressure (CPAP), were subdivided into two groups: Group D included desaturating who...
Background Studies on the inflammatory process in large airways of patients with mild/moderate COPD have shown a prevalent T lymphocyte and macrophage infiltration bronchial mucosa. However, inflammation more severe disease has not been extensively studied. Objective The aim present study was to characterize mucosa subjects severe, compared mild, COPD, examine relationship between airflow limitation numbers Methods We examined biopsies obtained from nine smokers limitation, 14 normal lung...